Discovering New Genes for Bowel Cancer

Abstract

Our aim is to discover new genes that greatly increase bowel cancer risk. If we can identify these carriers we may be able to prevent them getting cancer. By studying DNA related to bowel cancer, using a novel family design, we will identify families most likely to carry the new genes. We will focus genetic testing, using new techniques, to look for mutations in these prioritised families. Identified mutations will be tested in a 3,500 bowel cancer cases to see how important they are.

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Whether people who inherit a mutation in MUTYH from only one parent (monoallelic mutation) are at increased risk of colorectal can..