Sex hormones and social behaviour
Grant number: 628553 | Funding period: 2010 - 2012
Prevalence report by the Australian Advisory Board on Autism Spectrum Disorders (ASD) estimated that 1 child in every 160 children in the 6-12 year-old age group is affected by ASD. There is no cure for ASD and the causes are not understood. We propose that sex hormones may play a role in the development of these disorders. We will test this hypothesis using knockout and transgenic mouse models which have social interaction deficits and brain structure reminiscent of these disorders.
Related publications (8)
Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice
Michelle Van Sinderen, Gregory Steinberg, Sebastian B Jorgensen, Jane Honeyman, Jenny DY Chow, Evan R Simpson, Margaret EE Jones, Wah Chin Boon
We investigated the effects of estrogens on glucose homeostasis using the Aromatase Knockout (ArKO) mouse, which is unable to conv..
Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Amy L Winship, Evdokia Dimitriadis, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is su..
Characterization of Aromatase Expression in the Adult Male and Female Mouse Brain. I. Coexistence with Oestrogen Receptors alpha and beta, and Androgen Receptors
Davor Stanic, Sydney Dubois, Hui Kheng Chua, Bruce Tonge, Nicole Rinehart, Malcolm K Horne, Wah Chin Boon
Aromatase catalyses the last step of oestrogen synthesis. There is growing evidence that local oestrogens influence many brain reg..
Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
Michelle L Van Sinderen, Gregory R Steinberg, Sebastian B Jorgensen, Sarah Q To, Kevin C Knower, Colin D Clyne, Jane Honeyman, Jenny D Chow, Kerrie A Herridge, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
Estrogens are known to play a role in modulating metabolic processes within the body. The Aromatase knockout (ArKO) mice have been..
Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice
Rachel A Hill, Hui Kheng Chua, Margaret EE Jones, Evan R Simpson, Wah Chin Boon
The aromatase knockout (ArKO) mouse is completely estrogen deficient. We previously detected apoptosis in the hypothalamus of 1 ye..
Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively
Rachel A Hill, Jenny Chow, Karlheinrich Fritzemeier, Evan R Simpson, Wah Chin Boon
The aromatase (ArKO) knockout mouse is estrogen deficient. Our previous analysis revealed apoptosis of dopaminergic neurons in the..