Genes and Absence Epilepsy
Grant number: 628723 | Funding period: 2010 - 2012
The underlying genetic causes of idiopathic generalised epilepsies (IGE) are still largely unknown. In an animal model of IGE we have discovered novel genetic abnormalities an ion channel. This proposal will build upon these novel findings to examine the role these abnormalities have in determining the absence epilepsy phenotype and this work has the potential to provide vital information regarding the mechanisms by which this gene contributes to an IGE seizure phenotype.
Related publications (7)
Ca(v)3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg
Nihan Carcak, Idrish Ali, Kim Powell, Thomas Zheng, Filiz Onat, Terence J O'Brien
OBJECTIVE: Recent data indicate that amygdala kindling leads to significant changes in interictal neuronal firing patterns of thal..
Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model
Pablo Miguel Casillas-Espinosa, Ashleigh Hicks, Amy Jeffreys, Terrance P Snutch, Terence J O'Brien, Kim L Powell
Temporal lobe epilepsy (TLE) is the most common form of drug resistant epilepsy. Current treatment is symptomatic, suppressing sei..
The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy
Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien
OBJECTIVE: The co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent wit..
HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models
Kim L Powell, Nigel C Jones, Jeremy T Kennard, Caroline Ng, Vijay Urmaliya, Shannen Lau, Adora Tran, Thomas Zheng, Ezgi Ozturk, Gabi Dezsi, Ika Megatia, Lea M Delbridge, Didier Pinault, Christopher A Reid, Paul J White, Terence J O'Brien
OBJECTIVE: Evidence from animal and human studies indicates that epilepsy can affect cardiac function, although the molecular basi..
T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures
Elizabeth Tringham, Kim L Powell, Stuart M Cain, Kristy Kuplast, Janette Mezeyova, Manjula Weerapura, Cyrus Eduljee, Xinpo Jiang, Paula Smith, Jerrie-Lynn Morrison, Nigel C Jones, Emma Braine, Gil Rind, Molly Fee-Maki, David Parker, Hassan Pajouhesh, Manjeet Parmar, Terence J O'Brien, Terrance P Snutch
Absence seizures are a common seizure type in children with genetic generalized epilepsy and are characterized by a temporary loss..
Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg
JTT Kennard, R Barmanray, S Sampurno, E Ozturk, CA Reid, L Paradiso, GM D'Abaco, AH Kaye, SJ Foote, TJ O'Brien, KL Powell
Absence-like seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model are believed to arise in hyperexcitable s..