PI3K Mutations in Gastrointestinal Cancer

Grant number: 628621 | Funding period: 2010 - 2012

Completed

Abstract

Mutations in the PIK3CA gene are frequently found in bowel cancers but it remains unclear exactly how these mutations are involved in cancer development. We will exploit a unique mouse model to explore the role of PIK3CA mutations in the initiation, progression and-or metastasis of gastrointestinal cancers. This work will provide critical new insights into the biology of PIK3CA mutations and lead to the development of better models for the testing of new anti-cancer therapies.

Related publications (3)

Heterozygous expression of the oncogenic Pik3caH1047R mutation during murine development results in fatal embryonic and extraembryonic defects

LM Hare, Q Schwarz, S Wiszniak, R Gurung, KG Montgomery, CA Mitchell, WA Phillips

2015-08-01

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway regulates many cellular functions including proliferation, migration, ..

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

KM Kinross, KG Montgomery, SP Mangiafico, LM Hare, M Kleinschmidt, MJ Bywater, IJ Poulton, C Vrahnas, H Henneicke, J Malaterre, PM Waring, C Cullinane, NA Sims, GA McArthur, S Andrikopoulos, WA Phillips

2015-04-01

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most common mutations found in human can..

Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

LM Hare, TJ Phesse, PM Waring, KG Montgomery, KM Kinross, K Mills, V Roh, JK Heath, RG Ramsay, M Ernst, WA Phillips

2014-03-01

PIK3CA, the gene encoding the p110α catalytic subunit of PI3K (phosphoinositide 3-kinase), is mutated in approximately 20% of spor..

University of Melbourne Researchers

Wayne Phillips