Identifying protein changes in plasma after brief interruption and restoration of blood supply and heart surgery.

Grant number: 628756 | Funding period: 2010 - 2012

Completed

Abstract

Heart surgery with the heart placed into arrest causes inflammation and tissue damage due to interrupted circulation. We know that prior brief interruption and restoration of blood supply called remote ischemic preconditioning (IPC) can protect heart and lungs against damage. Our previous studies indicate that IPC involves a circulating factor that protects the tissue by optimizing energy preservation. This knowledge can be applied to organ transplants, protection from stroke and heart attack.