Identifying protein changes in plasma after brief interruption and restoration of blood supply and heart surgery.
Grant number: 628756 | Funding period: 2010 - 2012
Heart surgery with the heart placed into arrest causes inflammation and tissue damage due to interrupted circulation. We know that prior brief interruption and restoration of blood supply called remote ischemic preconditioning (IPC) can protect heart and lungs against damage. Our previous studies indicate that IPC involves a circulating factor that protects the tissue by optimizing energy preservation. This knowledge can be applied to organ transplants, protection from stroke and heart attack.
Related publications (3)
Cardiopulmonary bypass changes the plasma proteome in children undergoing tetralogy of Fallot repair
M Hepponstall, V Ignjatovic, S Binos, C Attard, V Karlaftis, Y d'Udekem, P Monagle, IE Konstantinov
INTRODUCTION: Cardiopulmonary bypass (CPB) can be associated with deleterious clinical effects. However, the impact of CPB on infl..
Remote Ischemic Preconditioning (RIPC) Modifies the Plasma Proteome in Children Undergoing Repair of Tetralogy of Fallot: A Randomized Controlled Trial
Michele Hepponstall, Vera Ignjatovic, Steve Binos, Chantal Attard, Vasiliki Karlaftis, Yves d'Udekem, Paul Monagle, Igor E Konstantinov
BACKGROUND: Remote ischemic preconditioning (RIPC) has been applied in paediatric cardiac surgery. We have demonstrated that RIPC ..
Remote Ischemic Preconditioning (RIPC) Modifies Plasma Proteome in Humans
Michele Hepponstall, Vera Ignjatovic, Steve Binos, Paul Monagle, Bryn Jones, Michael HH Cheung, Yves d'Udekem, Igor E Konstantinov
Remote Ischemic Preconditioning (RIPC) induced by brief episodes of ischemia of the limb protects against multi-organ damage by is..