Role of the Growth Factor ProGRP in the Development of Gastrointestinal Cancers
Grant number: 628390 | Funding period: 2010 - 2012
Our objective is to determine the roles of a growth factor termed bombesin. This peptide, known as GRP in the human, is a growth factor in certain lung cancers but little is known about its role in tumours of the colon. This project is based on our novel observation that the precursor of GRP (proGRP) previously thought to be inactive is in fact active in stimulating the growth of colon cancer cells. A successful outcome will result in novel treatments such as proGRP antagonists.
Related publications (4)
Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy
Joseph Ischia, Oneel Patel, Kapil Sethi, Marianne S Nordlund, Damien Bolton, Arthur Shulkes, Graham S Baldwin
OBJECTIVE: To determine the expression and biology of the neuroendocrine growth factor gastrin-releasing peptide (GRP) and other p..
Interferon Regulatory Factor 6 Differentially Regulates Toll-like Receptor 2-dependent Chemokine Gene Expression in Epithelial Cells
Mei Qi Kwa, Nguyen Thao, Huynh Jennifer, Divya Ramnath, Dominic De Nardo, Pui Yeng Lam, Eric C Reynolds, John A Hamilton, Matthew J Sweet, Glen M Scholz
Epidermal and mucosal epithelial cells are integral to host defense. They not only act as a physical barrier but also utilize patt..
The Role of Hypoxia-Inducible Factor 1 alpha in Determining the Properties of Castrate-Resistant Prostate Cancers
Weranja KB Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel
BACKGROUND: Castrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for..
Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)
Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel
Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates ..