Characterisation of a PIK3CA mutation in breast and ovarian cancer
Grant number: 628620 | Funding period: 2010 - 2012
PIK3CA mutations are frequently found in breast and ovarian cancers but how they cause cancer is not clear. We will exploit a unique mouse model to investigate the functional effects of PIK3CA mutations in cells and their role in cancer development. Understanding the mechanisms by which PIK3CA mutations regulate cell function and drive tumour growth will allow the rationale design of novel anti-cancer agents that specifically target this important cancer pathway.
Related publications (6)
PI3K activation in neural stem cells drives tumorigenesis which can be suppressed by targeting CREB
Paul Daniel, Gulay Filiz, Daniel Brown, Michael Christie, Paul Waring, Yi Zhang, John Haynes, Colin Pouton, Dustin Flanagan, Elizabeth Vincan, Terrance Johns, Karen Montgomery, Wayne Phillips, Theo Mantamadiotis
Hyperactivation of the PI3K signaling is common in human cancers, including gliomas, but the precise role of the pathway in glioma..
Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects
Lauren M Hare, Quenten Schwarz, Sophie Wiszniak, Rajendra Gurung, Karen G Montgomery, Christina A Mitchell, Wayne A Phillips
The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway regulates many cellular functions including proliferation, migration, ..
Ubiquitous expression of the Pik3ca(H1047R) mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly
Kathryn M Kinross, Karen G Montgomery, Salvatore P Mangiafico, Lauren M Hare, Margarete Kleinschmidt, Megan J Bywater, Ingrid J Poulton, Christina Vrahnas, Holger Henneicke, Jordane Malaterre, Paul M Waring, Carleen Cullinane, Natalie A Sims, Grant A McArthur, Sofianos Andrikopoulos, Wayne A Phillips
Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most common mutations found in human can..
Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors
Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips
BACKGROUND: Ovarian cancer is the major cause of death from gynaecological malignancy with a 5year survival of only ∼30% due to re..
Physiological Levels of Pik3ca(H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ER alpha-Positive Tumors
Anjali Tikoo, Vincent Roh, Karen G Montgomery, Ivan Ivetac, Paul Waring, Rebecca Pelzer, Lauren Hare, Mark Shackleton, Patrick Humbert, Wayne A Phillips
PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors inc..
An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice
Kathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, Paul Waring, Ivan Ivetac, Anjali Tikoo, Mirette Saad, Lauren Hare, Vincent Roh, Theo Mantamadiotis, Karen E Sheppard, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe, James G Christensen, Carleen Cullinane, Rodney J Hicks, Richard B Pearson, Ricky W Johnstone, Grant A McArthur
Mutations in the gene encoding the p110α subunit of PI3K (PIK3CA) that result in enhanced PI3K activity are frequently observed in..