Characterisation of a PIK3CA mutation in breast and ovarian cancer

Grant number: 628620 | Funding period: 2010 - 2012

Completed

Abstract

PIK3CA mutations are frequently found in breast and ovarian cancers but how they cause cancer is not clear. We will exploit a unique mouse model to investigate the functional effects of PIK3CA mutations in cells and their role in cancer development. Understanding the mechanisms by which PIK3CA mutations regulate cell function and drive tumour growth will allow the rationale design of novel anti-cancer agents that specifically target this important cancer pathway.

Related publications (6)

University of Melbourne Researchers