Free radicals in repair of the brain after stroke
Grant number: 628767 | Funding period: 2010 - 2013
Stroke is the third most common cause of death, results in considerable suffering and presents an enormous cost to health budgets. New research suggests that the injured brain can be stimulated to improve function. Generation of free radicals in the brain in the weeks after stroke may be important in long term recovery by promoting new blood vessel formation to suport brain repair. In this project we seek to identify how, when and where new blood vessels assist stem cell mediated repair.
Related publications (4)
Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
Hima CS Abeysinghe, Laita Bokhari, Anita Quigley, Mahesh Choolani, Jerry Chan, Gregory J Dusting, Jeremy M Crook, Nao R Kobayashi, Carli L Roulston
INTRODUCTION: Despite attempts to prevent brain injury during the hyperacute phase of stroke, most sufferers end up with significa..
Nox2 Knockout Delays Infarct Progression and Increases Vascular Recovery through Angiogenesis in Mice following Ischaemic Stroke with Reperfusion
Sarah K McCann, Gregory J Dusting, Carli L Roulston
Evidence suggests the NADPH oxidases contribute to ischaemic stroke injury and Nox2 is the most widely studied subtype in the cont..
NADPH Oxidase and Angiogenesis Following Endothelin-1 Induced Stroke in Rats: Role for Nox2 in Brain Repair
Caroline J Taylor, Robert M Weston, Gregory J Dusting, Carli L Roulston
NADPH oxidases contribute to brain injury, yet they may also have a role in brain repair, particularly in vascular signaling and a..