Genome-wide analysis of early ovarian neoplasms
Grant number: 628630 | Funding period: 2010 - 2012
Ovarian cancer is the 5th leading cause of cancer death in women. For such a significant disease, remarkably little is know about its origins and this has limited progress in developing more effective diagnostic markers. We will undertake cutting edge genome-wide analysis of pre-invasive ovarian tumours to identify genetic markers relevant to malignancy. This work will significantly expand our understanding of how ovarian cancers develops.
Related publications (5)
Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours
Sally M Hunter, Genevieve V Dall, Maria A Doyle, Richard Lupat, Jason Li, Prue Allan, Simone M Rowley, David Bowtell, Ian G Campbell, Kylie L Gorringe
OBJECTIVE: Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal c..
Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes
SM Hunter, MS Anglesio, GL Ryland, R Sharma, YE Chiew, SM Rowley, MA Doyle, J Li, CB Gilks, P Moss, PE Allan, AN Stephens, DG Huntsman, A deFazio, DD Bowtell, G Australian Ovarian Cancer Study, KL Gorringe, IG Campbell
Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with littl..
Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors
Georgina L Ryland, Sally M Hunter, Maria A Doyle, Franco Caramia, Jason Li, Simone M Rowley, Michael Christie, Prue E Allan, Andrew N Stephens, David DL Bowtell, Ian G Campbell, Kylie L Gorringe
BACKGROUND: Mucinous ovarian tumors are an unusual group of rare neoplasms with an apparently clear progression from benign to bor..
Pre-Invasive Ovarian Mucinous Tumors Are Characterized by CDKN2A and RAS Pathway Aberrations
Sally M Hunter, Kylie L Gorringe, Michael Christie, Simone M Rowley, David D Bowtell, Ian G Campbell
INTRODUCTION: Mucinous tumors are the second most common form of epithelial ovarian tumor, yet the cell of origin for this histolo..