Improving Cognition in Alzheimer's Disease

Grant number: 628491 | Funding period: 2010 - 2013

Completed

Abstract

The project investigates a brain molecule called p75, and the part it plays inmemory impairment in Alzheimer's Disease (AD). We predict that p75 is a vital link in the disease processes affecting memory.This research has the potential to lead to an effective treatment for AD, by stimulating work on compounds with the ability to blockthe damaging functions of p75.

Related publications (2)

In vivo knockdown of basal forebrain p75 neurotrophin receptor stimulates choline acetyltransferase activity in the mature hippocampus

GL Barrett, T Naim, J Trieu, M Huang

2016-05-01

This study seeks to determine whether knockdown of basal forebrain p75 neurotrophin receptor (p75<sup>NTR</sup>) expression elicit..

Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease

M Murphy, YM Wilson, E Vargas, KM Munro, B Smith, A Huang, QX Li, J Xiao, CL Masters, CA Reid, GL Barrett

2015-02-01

Alzheimer's disease (AD) is an extremely prevalent cause of dementia. It is characterized by progressive memory loss, confusion, a..

University of Melbourne Researchers

Mark Murphy