Re-Establishment of Connections After Spinal Cord Injury

Grant number: 628765 | Funding period: 2010 - 2015

Completed

Abstract

Our objective is to thoroughly investigate the connections made by regenerating nerve fibres in mice which are treated with specific compounds to inhibit scarring as well as with active exercise following spinal cord injury. This will provide evidence of the potential of these compounds as a therapeutic intervention. Understanding how the nervous system rewires following exercise intervention will provide insights as to how new connections can be shaped to ensure optimal recovery of function.

Related publications (10)

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Is more always better? How different ‘doses’ of exercise after incomplete spinal cord injury affects the membrane properties of deep dorsal horn interneurons

MM Rank, MP Galea, R Callister, RJ Callister

2018-02-01

Interneurons in the deep dorsal horn (DDH) of the spinal cord process somatosensory input, and form an important link between uppe..

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Effects Of treadmill training on hindlimb muscles of spinal cord–injured mice

CR Battistuzzo, MM Rank, JR Flynn, DL Morgan, R Callister, RJ Callister, MP Galea

2017-02-01

Introduction: Treadmill training is known to prevent muscle atrophy after spinal cord injury (SCI), but the training duration requ..

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Gait recovery following spinal cord injury in mice: Limited effect of treadmill training

CR Battistuzzo, MM Rank, JR Flynn, DL Morgan, R Callister, RJ Callister, MP Galea

2016-05-03

Several studies in rodents with complete spinal cord transections have demonstrated that treadmill training improves stepping move..

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Electrophysiological characterization of spontaneous recovery in deep dorsal horn interneurons after incomplete spinal cord injury

MM Rank, JR Flynn, MP Galea, R Callister, RJ Callister

2015-09-01

In the weeks and months following an incomplete spinal cord injury (SCI) significant spontaneous recovery of function occurs in th..

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Functional changes in deep dorsal horn interneurons following spinal cord injury are enhanced with different durations of exercise training

MM Rank, JR Flynn, CR Battistuzzo, MP Galea, R Callister, RJ Callister

2015-01-01

Following incomplete spinal cord injury (SCI), collaterals sprout from intact and injured axons in the vicinity of the lesion. The..

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Functional changes in deep dorsal horn interneurons following spinal cord injury are enhanced with different durations of exercise training.

MM Rank, JR Flynn, CR Battistuzzo, MP Galea, R Callister, RJ Callister

2015-01-01

Exercise training after spinal cord injury (SCI) enhances collateral sprouting from axons near the injury and is thought to promot..

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Exercise training after spinal cord injury selectively alters synaptic properties in neurons in adult mouse spinal cord

JR Flynn, LR Dunn, MP Galea, R Callister, RJ Callister, MM Rank

2013-05-15

Following spinal cord injury (SCI), anatomical changes such as axonal sprouting occur within weeks in the vicinity of the injury. ..

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A systematic review of exercise training to promote locomotor recovery in animal models of spinal cord injury

CR Battistuzzo, RJ Callister, R Callister, MP Galea

2012-05-20

In the early 1980s experiments on spinalized cats showed that exercise training on the treadmill could enhance locomotor recovery ..

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A Systematic Review of Exercise Training To Promote Locomotor Recovery in Animal Models of Spinal Cord Injury

Camila R Battistuzzo, Robert J Callister, Robin Callister, Mary P Galea

2012-05-01

<jats:p>In the early 1980s experiments on spinalized cats showed that exercise training on the treadmill could enhance locomotor r..

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A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord

JR Flynn, AM Brichta, MP Galea, RJ Callister, BA Graham

2011-09-15

In spinal cord injury (SCI) research, axon regeneration across spinal lesions is most often assessed using anatomical methods. It ..

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