Can we stop epilepsy from occurring in susceptible people

Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Tae Hwan Kim, Steven Petrou, Christopher A Reid

2014-01-01

PURPOSE: Clinical evidence suggests that low glycaemic index diets are effective at reducing seizure frequency potentially through..

Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice

Matilda Haas, Zhengdong Qu, Tae Hwan Kim, Ernesto Vargas, Kenneth Campbell, Steven Petrou, Seong-Seng Tan, Christopher A Reid, Julian Heng

2013-05-01

During brain development, many factors influence the assembly and final positioning of cortical neurons, and this process is essen..

Multiple molecular mechanisms for a single GABA(A) mutation in epilepsy

Christopher A Reid, Taehwan Kim, A Marie Phillips, Jun Low, Samuel F Berkovic, Bernhard Luscher, Steven Petrou

2013-03-01

OBJECTIVE: To understand the molecular basis and differential penetrance of febrile seizures and absence seizures in patients with..

Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility

Tae Hwan Kim, Kay Richards, Julian Heng, Steven Petrou, Christopher A Reid

2013-03-01

Conditional mouse models based on the Cre-recombinase (Cre)-loxP method are a powerful tool for determining the spatial and tempor..

Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility

Ernesto Vargas, Steven Petrou, Christopher A Reid

2013-01-01

The expression of Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) is responsible for high intracellular Cl(-) resulting in the excitatory ..

Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Tae Hwan Kim, Karin Borges, Steven Petrou, Christopher A Reid

2013-01-01

Triheptanoin is a triglyceride containing heptanoate, an odd-chained medium fatty acid that is metabolized to produce propionyl-Co..

HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications

Christopher A Reid, A Marie Phillips, Steven Petrou

2012-01-01

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN) can act as pacemakers in the brain making them strong candidate..

Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals

Christopher A Reid, Tae Hwan Kim, Samuel F Berkovic, Steven Petrou

2011-01-01

PURPOSE: Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence..