Can we stop epilepsy from occurring in susceptible people
Grant number: 628520 | Funding period: 2010 - 2012
Epilepsy is a serious condition having a massive impact on individuals and the community at large. Our understanding of the genetic causes of epilepsy is growing rapidly. We have created new animal models based on human mutations. We have shown that mutations can change the wiring of the brain during development so that the adult brain is more likely to become epileptic. Projects in this grant test if we can stop this developmental impact- allowing us to treat epilepsy before seizures occur.
Related publications (8)
Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
Tae Hwan Kim, Steven Petrou, Christopher A Reid
PURPOSE: Clinical evidence suggests that low glycaemic index diets are effective at reducing seizure frequency potentially through..
Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice
Matilda Haas, Zhengdong Qu, Tae Hwan Kim, Ernesto Vargas, Kenneth Campbell, Steven Petrou, Seong-Seng Tan, Christopher A Reid, Julian Heng
During brain development, many factors influence the assembly and final positioning of cortical neurons, and this process is essen..
Multiple molecular mechanisms for a single GABA(A) mutation in epilepsy
Christopher A Reid, Taehwan Kim, A Marie Phillips, Jun Low, Samuel F Berkovic, Bernhard Luscher, Steven Petrou
OBJECTIVE: To understand the molecular basis and differential penetrance of febrile seizures and absence seizures in patients with..
Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility
Tae Hwan Kim, Kay Richards, Julian Heng, Steven Petrou, Christopher A Reid
Conditional mouse models based on the Cre-recombinase (Cre)-loxP method are a powerful tool for determining the spatial and tempor..
Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility
Ernesto Vargas, Steven Petrou, Christopher A Reid
The expression of Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) is responsible for high intracellular Cl(-) resulting in the excitatory ..
Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
Tae Hwan Kim, Karin Borges, Steven Petrou, Christopher A Reid
Triheptanoin is a triglyceride containing heptanoate, an odd-chained medium fatty acid that is metabolized to produce propionyl-Co..
Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals
Christopher A Reid, Tae Hwan Kim, Samuel F Berkovic, Steven Petrou
PURPOSE: Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence..