Regulation of a hyperplasic tumour suppressor pathway by polarity complexes
Grant number: 628401 | Funding period: 2010 - 2012
Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and increased invasion-metastasis. We have discovered that a neoplastic tumour suppressor gene, lgl, acts though the Salvador-Warts-Hippo (SWH) tumour suppressor pathway to inhibit cell proliferation and cell survival. Here we use the model organism, Drosophila, and mammalian epithelial cells to determine the mechanism by which Lgl activates the SWH pathway.
Related publications (4)
The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State
Nezaket Turkel, Virender K Sahota, Jessica E Bolden, Karen R Goulding, Karen Doggett, Lee F Willoughby, Enrique Blanco, Enrique Martin-Blanco, Montserrat Corominas, Jason Ellul, Toshiro Aigaki, Helena E Richardson, Anthony M Brumby