Regulation of a hyperplasic tumour suppressor pathway by polarity complexes

Grant number: 628401 | Funding period: 2010 - 2012

Completed

Abstract

Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and increased invasion-metastasis. We have discovered that a neoplastic tumour suppressor gene, lgl, acts though the Salvador-Warts-Hippo (SWH) tumour suppressor pathway to inhibit cell proliferation and cell survival. Here we use the model organism, Drosophila, and mammalian epithelial cells to determine the mechanism by which Lgl activates the SWH pathway.

Related publications (6)

Scholarly works icon

miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila

Scott G Daniel, Atlantis D Russ, Kathryn M Guthridge, Ammad I Raina, Patricia S Estes, Linda M Parsons, Helena E Richardson, Joyce A Schroeder, Daniela C Zarnescu

2018-01-01

Drosophila lethal giant larvae (lgl) encodes a conserved tumor suppressor with established roles in cell polarity, asymmetric divi..

Scholarly works icon

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

Linda M Parsons, Nicola A Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M Quinn, Helena E Richardson

2017-08-01

In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper ..

Scholarly works icon

Lgl Regulates Notch Signaling via Endocytosis, Independently of the Apical aPKC-Par6-Baz Polarity Complex

Linda M Parsons, Marta Portela, Nicola A Grzeschik, Helena E Richardson

2014-09-22

BACKGROUND: The Drosophila melanogaster junctional neoplastic tumor suppressor, Lethal-2-giant larvae (Lgl), is a regulator of api..

Scholarly works icon

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK

Linda Parsons, Nicola Grzeschik, Helena Richardson

2014-06-01

In both Drosophila and mammalian systems, the Hippo (Hpo) signalling pathway controls tissue growth by inhibiting cell proliferati..

Scholarly works icon

The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State

Nezaket Turkel, Virender K Sahota, Jessica E Bolden, Karen R Goulding, Karen Doggett, Lee F Willoughby, Enrique Blanco, Enrique Martin-Blanco, Montserrat Corominas, Jason Ellul, Toshiro Aigaki, Helena E Richardson, Anthony M Brumby

2013-07-01

The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewa..

Scholarly works icon

Actin up for Hippo

Helena E Richardson

2011-06-15

University of Melbourne Researchers