Restoring skeletal muscle in an experimental model of Chronic Obstructive Pulmonary Disease
Grant number: 628492 | Funding period: 2010 - 2014
Most people think that the serious disabilities of COPD (emphysema) patients follows damage to their lungs but wasted muscles may be even more important. We can not regrow lung but we have found a way that might help regrow muscle. We plan to use stem cells to make one of the body's own cells called 'macrophages' and genetically engineer these cells to help deliver healing proteins directly into the muscle. Making muscle stronger will help COPD patients live longer and improve quality of life.
Related publications (3)
IL-17A and Serum Amyloid A Are Elevated in a Cigarette Smoke Cessation Model Associated with the Persistence of Pigmented Macrophages, Neutrophils and Activated NK Cells
Michelle J Hansen, Sheau Pyng J Chan, Shenna Y Langenbach, Lovisa F Dousha, Jessica E Jones, Selcuk Yatmaz, Huei Jiunn Seow, Ross Vlahos, Gary P Anderson, Steven Bozinovski