Repairing The Brain In Parkinson'S Disease
Grant number: 628542 | Funding period: 2010 - 2012
Many obstacles exist for cell transplantation in Parkinson's disease; namely poor restoration of the host brain circuitry due to incorrect graft placement. This results in incomplete motor function and unwanted side effects. Through iterative studies we endeavor to restore this circuitry by placing grafts in the appropriate location and promoting their survival and growth-integrations. This will require: optimizing the donor tissue and exposure of the graft to growth stimulating factors.
Related publications (5)
Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation
Mark Denham, Clare L Parish, Bryan Leaw, Jordan Wright, Christopher A Reid, Steven Petrou, Mirella Dottori, Lachlan H Thompson