Understanding how cytotoxic lymphocytes protect against cancer
Grant number: 628485 | Funding period: 2010 - 2013
Related publications (19)
Defining the interaction of perforin with calcium and the phospholipid membrane
Daouda AK Traore, Amelia J Brennan, Ruby HP Law, Con Dogovski, Matthew A Perugini, Natalya Lukoyanova, Eleanor WW Leung, Raymond S Norton, Jamie A Lopez, Kylie A Browne, Hideo Yagita, Gordon J Lloyd, Annette Ciccone, Sandra Verschoor, Joseph A Trapani, James C Whisstock, Ilia Voskoboinik
Following its secretion from cytotoxic lymphocytes into the immune synapse, perforin binds to target cell membranes through its Ca..
Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin
Julie A Spicer, Gersande Lena, Dani M Lyons, Kristiina M Huttunen, Christian K Miller, Patrick D O'Connor, Matthew Bull, Nuala Helsby, Stephen MF Jamieson, William A Denny, Annette Ciccone, Kylie A Browne, Jamie A Lopez, Jesse Rudd-Schmidt, Ilia Voskoboinik, Joseph A Trapani
A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming..
Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
O Susanto, SE Stewart, I Voskoboinik, D Brasacchio, M Hagn, S Ellis, S Asquith, KA Sedelies, PI Bird, NJ Waterhouse, JA Trapani
Human and mouse granzyme (Gzm)B both induce target cell apoptosis in concert with pore-forming perforin (Pfp); however the mechani..
Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse
Jamie A Lopez, Misty R Jenkins, Jesse A Rudd-Schmidt, Amelia J Brennan, Jillian C Danne, Stuart I Mannering, Joseph A Trapani, Ilia Voskoboinik
The effective engagement of cytotoxic lymphocytes (CLs) with their target cells is essential for the removal of virus-infected and..
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
Jamie A Lopez, Olivia Susanto, Misty R Jenkins, Natalya Lukoyanova, Vivien R Sutton, Ruby HP Law, Angus Johnston, Catherina H Bird, Phillip I Bird, James C Whisstock, Joseph A Trapani, Helen R Saibil, Ilia Voskoboinik
Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected and transformed target cells through th..
Human perforin mutations and susceptibility to multiple primary cancers
Joseph A Trapani, Kevin YT Thia, Miles Andrews, Ian D Davis, Craig Gedye, Philip Parente, Suzanne Svobodova, Jenny Chia, Kylie Browne, Ian G Campbell, Wayne A Phillips, Ilia Voskoboinik, Jonathan S Cebon
Loss-of-function mutations in the gene coding for perforin (PRF1) markedly reduce the ability of cytotoxic T lymphocytes and natur..
Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death
Jamie A Lopez, Amelia J Brennan, James C Whisstock, Ilia Voskoboinik, Joseph A Trapani
Considerable progress has been made in understanding how cytotoxic lymphocytes use the highly toxic pore-forming protein perforin ..
Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin
Jenny Chia, Kevin Thia, Amelia J Brennan, Margaret Little, Bronwyn Williams, Jamie A Lopez, Joseph A Trapani, Ilia Voskoboinik
Mutations in the perforin gene (PRF1) are a common cause of the fatal immune dysregulation disorder, familial hemophagocytic lymph..
Molecular study of the perforin gene in familial hematological malignancies
Rim El Abed, Violaine Bourdon, Ilia Voskoboinik, Halima Omri, Yosra Ben Youssef, Mohamed Adnene Laatiri, Laetitia Huiart, Francois Eisinger, Laetitia Rabayrol, Marc Frenay, Paul Gesta, Liliane Demange, Helene Dreyfus, Valerie Bonadona, Catherine Dugast, Helene Zattara, Laurence Faivre, Monia Zaier, Saloua Yacoub Jemni, Testsuro Noguchi
Perforin gene (PRF1) mutations have been identified in some patients diagnosed with the familial form of hemophagocytic lymphohist..
Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes
Amelia J Brennan, Jenny Chia, Kylie A Browne, Annette Ciccone, Sarah Ellis, Jamie A Lopez, Olivia Susanto, Sandra Verschoor, Hideo Yagita, James C Whisstock, Joseph A Trapani, Ilia Voskoboinik
Cytotoxic lymphocyte-mediated apoptosis is dependent on the delivery of perforin to secretory granules and its ability to form cal..
Cytotoxic granules house potent proapoptotic toxins critical for antiviral responses and immune homeostasis
K Baran, I Voskoboinik, NJ Waterhouse, VR Sutton, JA Trapani
General Introduction Cytotoxic lymphocytes and apoptosis The immune system of high-order organisms is a highly specialized compart..
The structural basis for membrane binding and pore formation by lymphocyte perforin
Ruby HP Law, Natalya Lukoyanova, Ilia Voskoboinik, Tom T Caradoc-Davies, Katherine Baran, Michelle A Dunstone, Michael E D'Angelo, Elena V Orlova, Fasseli Coulibaly, Sandra Verschoor, Kylie A Browne, Annette Ciccone, Michael J Kuiper, Phillip I Bird, Joseph A Trapani, Helen R Saibil, James C Whisstock
Natural killer cells and cytotoxic T lymphocytes accomplish the critically important function of killing virus-infected and neopla..
The structure and function of mammalian membrane-attack complex/perforin-like proteins
SC Kondos, T Hatfaludi, I Voskoboinik, JA Trapani, RHP Law, JC Whisstock, MA Dunstone
The membrane-attack complex (MAC) of complement pathway and perforin (PF) are important tools deployed by the immune system to tar..
Perforin: structure, function, and role in human immunopathology
Ilia Voskoboinik, Michelle A Dunstone, Katherine Baran, James C Whisstock, Joseph A Trapani
The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and transformed target ce..