Specific Brain Networks Related to the Symptoms of Obsessive-Compulsive Disorder
Grant number: 628509 | Funding period: 2010 - 2014
Related publications (57)
Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder
Monica Gimenez, Andres Guinea-Izquierdo, Victoria Villalta-Gil, Ignacio Martinez-Zalacain, Cinto Segalas, Marta Subira, Eva Real, Jesus Pujol, Ben J Harrison, Josep Maria Haro, Joao R Sato, Marcelo Q Hoexter, Narcis Cardoner, Pino Alonso, Jose Manuel Menchon, Carles Soriano-Mas
The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Al..
Attenuated frontal and sensory inputs to the basal ganglia in cannabis users
Laura Blanco-Hinojo, Jesus Pujol, Ben J Harrison, Didac Macia, Albert Batalla, Santiago Nogue, Marta Torrens, Magi Farre, Joan Deus, Rocio Martin-Santos
Heavy cannabis use is associated with reduced motivation. The basal ganglia, central in the motivation system, have the brain's hi..
Anomalous basal ganglia connectivity and obsessive-compulsive behaviour in patients with Prader Willi syndrome
Jesus Pujol, Laura Blanco-Hinojo, Susanna Esteba-Castillo, Assumpta Caixas, Ben J Harrison, Marta Bueno, Joan Deus, Mercedes Rigla, Didac Macia, Jone Llorente-Onaindia, Ramon Novell-Alsina
BACKGROUND: Prader Willi syndrome is a genetic disorder with a behavioural expression characterized by the presence of obsessive-c..
Neurodevelopmental correlates of proneness to guilt and shame in adolescence and early adulthood
Sarah Whittle, Kirra Liu, Coralie Bastin, Ben J Harrison, Christopher G Davey
Investigating how brain development during adolescence and early adulthood underlies guilt- and shame-proneness may be important f..
Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting
Ian H Harding, Ben J Harrison, Michael Breakspear, Christos Pantelis, Murat Yuecel
Cognitive control (CC) and working memory (WM) are concurrently necessary for adaptive human behavior. These processes are thought..
Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study
Clara Lopez-Sola, Leonardo F Fontenelle, Minh Bui, John L Hopper, Christos Pantelis, Murat Yuecel, Jose M Menchon, Pino Alonso, Ben J Harrison
BACKGROUND: The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including obsessive-compulsive disord..
Brain Functional Correlates of Emotion Regulation Across Adolescence and Young Adulthood
Katerina Stephanou, Christopher G Davey, Rebecca Kerestes, Sarah Whittle, Jesus Pujol, Murat Yuecel, Alex Fornito, Marina Lopez-Sola, Ben J Harrison
Few studies have examined the neural correlates of emotion regulation across adolescence and young adulthood. Existing studies of ..
Functional Connectivity Bias in the Prefrontal Cortex of Psychopaths
Oren Contreras-Rodriguez, Jesus Pujol, Iolanda Batalla, Ben J Harrison, Carles Soriano-Mas, Joan Deus, Marina Lopez-Sola, Didac Macia, Vanessa Pera, Rosa Hernandez-Ribas, Josep Pifarre, Jose M Menchon, Narcis Cardoner
BACKGROUND: Psychopathy is characterized by a distinctive interpersonal style that combines callous-unemotional traits with inflex..
A Neural Mediator of Human Anxiety Sensitivity
Ben J Harrison, Miquel A Fullana, Carles Soriano-Mas, Esther Via, Jesus Pujol, Ignacio Martinez-Zalacain, Daniella Tinoco-Gonzalez, Christopher G Davey, Marina Lopez-Sola, Victor Perez Sola, Jose M Menchon, Narcis Cardoner
Advances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that hum..
Abnormal Social Reward Responses in Anorexia Nervosa: An fMRI Study
Esther Via, Carles Soriano-Mas, Isabel Sanchez, Laura Forcano, Ben J Harrison, Christopher G Davey, Jesus Pujol, Ignacio Martinez-Zalacain, Jose M Menchon, Fernando Fernandez-Aranda, Narcis Cardoner
Patients with anorexia nervosa (AN) display impaired social interactions, implicated in the development and prognosis of the disor..
Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for Psychosis
Kareen Heinze, Renate LEP Reniers, Barnaby Nelson, Alison R Yung, Ashleigh Lin, Ben J Harrison, Christos Pantelis, Dennis Velakoulis, Patrick D McGorry, Stephen J Wood
BACKGROUND: Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse..
Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression
CG Davey, S Whittle, BJ Harrison, JG Simmons, ML Byrne, OS Schwartz, NB Allen
BACKGROUND: The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affec..
A selective involvement of putamen functional connectivity in youth with internet gaming disorder
Soon-Beom Hong, Ben J Harrison, Orwa Dandash, Eun-Jung Choi, Seong-Chan Kim, Ho-Hyun Kim, Do-Hyun Shim, Chang-Dai Kim, Jae-Won Kim, Soon-Hyung Yi
Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a re..
Effective connectivity within the frontoparietal control network differentiates cognitive control and working memory
Ian H Harding, Murat Yuecel, Ben J Harrison, Christos Pantelis, Michael Breakspear
Cognitive control and working memory rely upon a common fronto-parietal network that includes the inferior frontal junction (IFJ),..
Hoarding pet animals in obsessive-compulsive disorder
Andre L Campos-Lima, Albina R Torres, Murat Yuecel, Ben J Harrison, Jorge Moll, Gabriela M Ferreira, Leonardo F Fontenelle
BACKGROUND: Although severe hoarding symptoms have been considered rare among obsessive-compulsive disorder (OCD) samples, the pre..
Selective Augmentation of Striatal Functional Connectivity Following NMDA Receptor Antagonism: Implications for Psychosis
Orwa Dandash, Ben J Harrison, Ram Adapa, Raphael Gaillard, Francesco Giorlando, Stephen J Wood, Paul C Fletcher, Alex Fornito
The psychotomimetic effect of the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine is thought to arise from a functional ..
Functional dysconnectivity of corticostriatal circuitry and differential response to methylphenidate in youth with attention-deficit/hyperactivity disorder
Soon-Beom Hong, Ben J Harrison, Alex Fornito, Chul-Ho Sohn, In-Chan Song, Jae-Won Kim
BACKGROUND: Brain frontostriatal circuits have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder ..
The neural cascade of olfactory processing: A combined fMRI-EEG study
Yuri Masaoka, Ian H Harding, Nobuyoshi Koiwa, Masaki Yoshida, Ben J Harrison, Valentina Lorenzetti, Masahiro Ida, Masahiko Izumizaki, Christos Pantelis, Ikuo Homma
Olfaction is dependent on respiration for the delivery of odorants to the nasal cavity. Taking advantage of the time-locked nature..
The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): study protocol for a randomised control trial
Christopher G Davey, Andrew M Chanen, Sue M Cotton, Sarah E Hetrick, Melissa J Kerr, Michael Berk, Olivia M Dean, Kally Yuen, Mark Phelan, Aswin Ratheesh, Miriam R Schaefer, G Paul Amminger, Alexandra G Parker, Danijela Piskulic, Susy Harrigan, Andrew J Mackinnon, Ben J Harrison, Patrick D McGorry
BACKGROUND: The aim of the Youth Depression Alleviation-Combined Treatment (YoDA-C) study is to determine whether antidepressant m..
Altered Functional Magnetic Resonance Imaging Responses to Nonpainful Sensory Stimulation in Fibromyalgia Patients
Marina Lopez-Sola, Jesus Pujol, Tor D Wager, Alba Garcia-Fontanals, Laura Blanco-Hinojo, Susana Garcia-Blanco, Violant Poca-Dias, Ben J Harrison, Oren Contreras-Rodriguez, Jordi Monfort, Ferran Garcia-Fructuoso, Joan Deus
OBJECTIVE: Fibromyalgia (FM) is a disorder characterized by chronic pain and enhanced responses to acute noxious events. However, ..
Disruption of brain white matter microstructure in women with anorexia nervosa
Esther Via, Andrew Zalesky, Isabel Sanchez, Laura Forcano, Ben J Harrison, Jesus Pujol, Fernando Fernandez-Aranda, Jose Manuel Menchon, Carles Soriano-Mas, Narcis Cardoner, Alex Fornito
BACKGROUND: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its ..
Does motion-related brain functional connectivity reflect both artifacts and genuine neural activity?
Jesus Pujol, Didac Macia, Laura Blanco-Hinojo, Gerard Martinez-Vilavella, Jordi Sunyer, Rafael de la Torre, Assumpta Caixas, Rocio Martin-Santos, Joan Deus, Ben J Harrison
Imaging research on functional connectivity is uniquely contributing to characterize the functional organization of the human brai..
The contribution of sensory system functional connectivity reduction to clinical pain in fibromyalgia
Jesus Pujol, Didac Macia, Alba Garcia-Fontanals, Laura Blanco-Hinojo, Marina Lopez-Sola, Susana Garcia-Blanco, Violant Poca-Dias, Ben J Harrison, Oren Contreras-Rodriguez, Jordi Monfort, Ferran Garcia-Fructuoso, Joan Deus
Fibromyalgia typically presents with spontaneous body pain with no apparent cause and is considered pathophysiologically to be a f..
Altered Striatal Functional Connectivity in Subjects With an At-Risk Mental State for Psychosis
Orwa Dandash, Alex Fornito, Jimmy Lee, Richard SE Keefe, Michael WL Chee, R Alison Adcock, Christos Pantelis, Stephen J Wood, Ben J Harrison
Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal stri..
Modulation of brain structure by catechol-O-methyltransferase Val(158)Met polymorphism in chronic cannabis users
Albert Batalla, Carles Soriano-Mas, Marina Lopez-Sola, Marta Torrens, Jose A Crippa, Sagnik Bhattacharyya, Laura Blanco-Hinojo, Ana B Fagundo, Ben J Harrison, Santiago Nogue, Rafael de la Torre, Magi Farre, Jesus Pujol, Rocio Martin-Santos
Neuroimaging studies have shown that chronic consumption of cannabis may result in alterations in brain morphology. Recent work fo..
The Psychiatric Facet of Hyperhidrosis: Demographics, Disability, Quality of Life, and Associated Psychopathology
Larissa da R Lessa, Flavio B Luz, Rebeca M de Rezende, Sandra M Duraes, Ben J Harrison, Gabriela B de Menezes, Leonardo F Fontenelle
We compared the sociodemographic and psychiatric features of treatment-seeking patients with (n=17) and without (n=29) primary hyp..
Prevalence and Heritability of Obsessive-Compulsive Spectrum and Anxiety Disorder Symptoms: A Survey of the Australian Twin Registry
Clara Lopez-Sola, Leonardo F Fontenelle, Pino Alonso, Daniel Cuadras, Debra L Foley, Christos Pantelis, Jesus Pujol, Murat Yuecel, Narcis Cardoner, Carles Soriano-Mas, Jose M Menchon, Ben J Harrison
While past twin studies indicate moderate levels of heritability of "obsessive-compulsive related" and anxiety disorder symptoms, ..
Brain structural imaging correlates of olfactory dysfunction in obsessive-compulsive disorder
Cinto Segalas, Pino Alonso, Arantxa Orbegozo, Eva Real, Marta Subira, Clara Lopez-Sola, Ignacio Martinez-Zalacain, Javier Labad, Ben J Harrison, Jesus Pujol, Jose M Menchon, Narcis Cardoner, Carles Soriano-Mas
Olfactory dysfunction has been described in obsessive-compulsive disorder (OCD). Brain regions involved in smell processing partia..
Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users
Jesus Pujol, Laura Blanco-Hinojo, Albert Batalla, Marina Lopez-Sola, Ben J Harrison, Carles Soriano-Mas, Jose A Crippa, Ana B Fagundo, Joan Deus, Rafael de la Torre, Santiago Nogue, Magi Farre, Marta Torrens, Rocio Martin-Santos
BACKGROUND: Recreational drugs are generally used to intentionally alter conscious experience. Long-lasting cannabis users frequen..
Amygdala activation and symptom dimensions in obsessive compulsive disorder
Esther Via, Narcis Cardoner, Jesus Pujol, Pino Alonso, Marina Lopez-Sola, Eva Real, Oren Contreras-Rodriguez, Joan Deus, Cinto Segalas, Jose M Menchon, Carles Soriano-Mas, Ben J Harrison
BACKGROUND: Despite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology of obsessive-co..
Neural correlates of obsessive-compulsive related dysfunctional beliefs
Pino Alonso, Arantxa Orbegozo, Jesus Pujol, Clara Lopez-Sola, Miquel Angel Fullana, Cinto Segalas, Eva Real, Marta Subira, Ignacio Martinez-Zalacain, Jose M Menchon, Ben J Harrison, Narcis Cardoner, Carles Soriano-Mas
There have been few attempts to integrate neurobiological and cognitive models of obsessive-compulsive disorder (OCD), although th..
Functional Dysconnectivity of Corticostriatal Circuitry as a Risk Phenotype for Psychosis
Alex Fornito, Ben J Harrison, Emmeline Goodby, Anna Dean, Cinly Ooi, Pradeep J Nathan, Belinda R Lennox, Peter B Jones, John Suckling, Edward T Bullmore
IMPORTANCE: Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology of psychotic disorders..
Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive Obsessions
Marta Subira, Pino Alonso, Cinto Segalas, Eva Real, Clara Lopez-Sola, Jesus Pujol, Ignacio Martinez-Zalacain, Ben J Harrison, Jose M Menchon, Narcis Cardoner, Carles Soriano-Mas
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consi..
Structural covariance of the neostriatum with regional gray matter volumes
C Soriano-Mas, BJ Harrison, J Pujol, M Lopez-Sola, R Hernandez-Ribas, P Alonso, O Contreras-Rodriguez, M Gimenez, L Blanco-Hinojo, H Ortiz, J Deus, JM Menchon, N Cardoner
The caudate and putamen nuclei have been traditionally divided into dorsal and ventral territories based on their segregated patte..
Neural response to the observable self in social anxiety disorder
J Pujol, M Gimenez, H Ortiz, C Soriano-Mas, M Lopez-Sola, M Farre, J Deus, E Merlo-Pich, BJ Harrison, N Cardoner, R Navines, R Martin-Santos
BACKGROUND: Distorted images of the observable self are considered crucial in the development and maintenance of social anxiety. W..
Brain Corticostriatal Systems and the Major Clinical Symptom Dimensions of Obsessive-Compulsive Disorder
Ben J Harrison, Jesus Pujol, Narcis Cardoner, Joan Deus, Pino Alonso, Marina Lopez-Sola, Oren Contreras-Rodriguez, Eva Real, Cinto Segalas, Laura Blanco-Hinojo, Jose M Menchon, Carles Soriano-Mas
BACKGROUND: Functional neuroimaging studies have provided consistent support for the idea that obsessive-compulsive disorder (OCD)..
Breakdown in the brain network subserving moral judgment in criminal psychopathy
Jesus Pujol, Iolanda Batalla, Oren Contreras-Rodriguez, Ben J Harrison, Vanessa Pera, Rosa Hernandez-Ribas, Eva Real, Laura Bosa, Carles Soriano-Mas, Joan Deus, Marina Lopez-Sola, Josep Pifarre, Jose M Menchon, Narcis Cardoner
Neuroimaging research has demonstrated the involvement of a well-defined brain network in the mediation of moral judgment in norma..
Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder
CG Davey, BJ Harrison, M Yuecel, NB Allen
BACKGROUND: Depression has been associated with functional alterations in several areas of the cingulate cortex. In this study we ..
Competitive and cooperative dynamics of large-scale brain functional networks supporting recollection
Alex Fornito, Ben J Harrison, Andrew Zalesky, Jon S Simons
Analyses of functional interactions between large-scale brain networks have identified two broad systems that operate in apparent ..
Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder
Leonardo F Fontenelle, Ben J Harrison, Jesus Pujol, Christopher G Davey, Alex Fornito, Emre Bora, Christos Pantelis, Murat Yuecel
BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining sympt..
Functional Connectivity in Brain Networks Underlying Cognitive Control in Chronic Cannabis Users
Ian H Harding, Nadia Solowij, Ben J Harrison, Michael Takag, Valentina Lorenzetti, Dan I Lubman, Marc L Seal, Christos Pantelis, Murat Yuecel
The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control a..
Neural Correlates of Moral Sensitivity in Obsessive-Compulsive Disorder
Ben J Harrison, Jesus Pujol, Carles Soriano-Mas, Rosa Hernandez-Ribas, Marina Lopez-Sola, Hector Ortiz, Pino Alonso, Joan Deus, Jose M Menchon, Eva Real, Cinto Segalas, Oren Contreras-Rodriguez, Laura Blanco-Hinojo, Narcis Cardoner
CONTEXT: Heightened moral sensitivity seems to characterize patients with obsessive-compulsive disorder (OCD). Recent advances in ..
Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorder
E Bora, BJ Harrison, CG Davey, M Yuecel, C Pantelis
BACKGROUND: Abnormalities in cortico-striatal-pallidal-thalamic (CSPT) circuits have been implicated in major depressive disorder ..
Towards a post-traumatic subtype of obsessive-compulsive disorder
Leonardo F Fontenelle, Luca Cocchi, Ben J Harrison, Roseli G Shavitt, Maria Conceicao do Rosario, Ygor A Ferrao, Maria Alice de Mathis, Aristides V Cordioli, Murat Yuecel, Christos Pantelis, Jair de Jesus Mari, Euripedes C Miguel, Albina R Torres
We evaluated whether traumatic events are associated with a distinctive pattern of socio-demographic and clinical features of obse..
Task-related deactivation and functional connectivity of the subgenual cingulate cortex in major depressive disorder.
Christopher G Davey, Murat Yücel, Nicholas B Allen, Ben J Harrison
BACKGROUND: Major depressive disorder is associated with functional alterations in activity and resting-state connectivity of the ..
White matter microstructure in opiate addiction
Emre Bora, Murat Yuecel, Alex Fornito, Christos Pantelis, Ben J Harrison, Luca Cocchi, Gaby Pell, Dan I Lubman
Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially ex..
Enhanced brain responsiveness during active emotional face processing in obsessive compulsive disorder
Narcis Cardoner, Ben J Harrison, Jesus Pujol, Carles Soriano-Mas, Rosa Hernandez-Ribas, Marina Lopez-Sola, Eva Real, Joan Deus, Hector Ortiz, Pino Alonso, Jose M Menchon
OBJECTIVES. The abnormal processing of emotional stimuli is common to a variety of psychiatric disorders. Specifically, patients w..
Increased Amygdala Response to Positive Social Feedback in Young People with Major Depressive Disorder
Christopher G Davey, Nicholas B Allen, Ben J Harrison, Murat Yuecel
BACKGROUND: Studies of depressed patients have demonstrated increased amygdala activation to negative affective stimuli. In this s..
Cross-Sectional and Longitudinal Assessment of Structural Brain Alterations in Melancholic Depression
Carles Soriano-Mas, Rosa Hernandez-Ribas, Jesus Pujol, Mikel Urretavizcaya, Joan Deus, Ben J Harrison, Hector Ortiz, Marina Lopez-Sola, Josep M Menchon, Narcis Cardoner
BACKGROUND: Whole-brain imaging approaches may contribute to the characterization of neuroanatomic alterations in major depression..
Role of stressful and traumatic life events in obsessive-compulsive disorder
Leonardo F Fontenelle, Luca Cocchi, Ben J Harrison, Euripedes C Miguel, Albina R Torres
Whilst genetic factors are thought to contribute to the development of obsessive-compulsive disorder (OCD), the role of environmen..
White matter microstructure in patients with obsessive-compulsive disorder
Emre Bora, Ben J Harrison, Alex Fornito, Luca Cocchi, Jesus Pujol, Leonardo F Fontenelle, Dennis Velakoulis, Christos Pantelis, Murat Yuecel
BACKGROUND: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inc..
Effects of Duloxetine Treatment on Brain Response to Painful Stimulation in Major Depressive Disorder
Marina Lopez-Sola, Jesus Pujol, Rosa Hernandez-Ribas, Ben J Harrison, Oren Contreras-Rodriguez, Carles Soriano-Mas, Joan Deus, Hector Ortiz, Jose M Menchon, Julio Vallejo, Narcis Cardoner
Major depressive disorder (MDD) is characterized by a constellation of affective, cognitive, and somatic symptoms associated with ..