Mood disorders in epilepsy

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones

2016-09-01

INTRODUCTION: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on..

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

MR Hudson, G Rind, TJ O'Brien, NC Jones

2016-04-19

Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely ti..

Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

Meng Yang, Ezgi Ozturk, Michael R Salzberg, Sandra Rees, Margaret Morris, Terence J O'Brien, Nigel C Jones

2016-03-01

OBJECTIVE: Environmental exposures impart powerful effects on vulnerability to many brain diseases, including epilepsy. Mesial tem..

Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

Amelia S Koe, Michael R Salzberg, Margaret J Morris, Terence J O'Brien, Nigel C Jones

2014-04-01

Early life stress causes long-lasting effects on the limbic system that may be relevant to the development of mesial temporal lobe..

Chronic antidepressant treatment accelerates kindling epileptogenesis in rats

Lisa Cardamone, Michael R Salzberg, Amelia S Koe, Ezgi Ozturk, Terence J O'Brien, Nigel C Jones

2014-03-01

OBJECTIVES: Due to the high comorbidity of epilepsy and depression, antidepressant treatment is commonly indicated for patients wi..

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

Gabi Dezsi, Ezgi Ozturk, Davor Stanic, Kim L Powell, Hal Blumenfeld, Terence J O'Brien, Nigel C Jones

2013-04-01

PURPOSE: Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has ..