RESEARCH FELLOWSHIP - ASSOC PROF BARBARA COULSON
Grant number: 628319 | Funding period: 2010 - 2015
I am a virologist carrying out research to determine the mechanisms underlying rotavirus cellular tropism and the pathogenesis of rotavirus disease. Rotavirus is the major cause of infantile gastroenteritis worldwide. I am combining the expertise of my group in rotavirus biology with the power of inter-disciplinary collaborations in the areas of sugar chemistry, cell biology, structural biology and diabetes to expand understanding in these areas. Novel treatments and improvements in rotavirus vaccines are the long term goal of our research.
Related publications (17)
MHC class I expression in intestinal cells is reduced by rotavirus infection and increased in bystander cells lacking rotavirus antigen
Gavan Holloway, Fiona E Fleming, Barbara S Coulson
Detection of viral infection by host cells leads to secretion of type I interferon, which induces antiviral gene expression. The c..
Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling
Jessica A Pane, Fiona E Fleming, Kate L Graham, Helen E Thomas, Thomas WH Kay, Barbara S Coulson
Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates dia..
Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection
Xing Yu, Rahul Mishra, Gavan Holloway, Mark von Itzstein, Barbara S Coulson, Helen Blanchard
Rotavirus-cell binding is the essential first step in rotavirus infection. This binding is a major determinant of rotavirus tropis..
Innate immune responses to rotavirus infection in macrophages depend on MAVS but involve neither the NLRP3 inflammasome nor JNK and p38 signaling pathways
Izabel JM Di Fiore, Gavan Holloway, Barbara S Coulson
Rotavirus infection is a major cause of life-threatening infantile gastroenteritis. The innate immune system provides an immediate..
NSP1 of human rotaviruses commonly inhibits NF-kappa B signalling by inducing beta-TrCP degradation
Izabel JM Di Fiore, Jessica A Pane, Gavan Holloway, Barbara S Coulson
Rotavirus is a leading cause of severe gastroenteritis in infants worldwide. Rotavirus nonstructural protein 1 (NSP1) is a virulen..
Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion
Raphael Boehm, Fiona E Fleming, Andrea Maggioni, Vi T Dang, Gavan Holloway, Barbara S Coulson, Mark von Itzstein, Thomas Haselhorst
Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewis(b) antigens have been reported to..
VP7 of Rhesus monkey rotavirus RRV contributes to diabetes acceleration in association with an elevated anti-rotavirus antibody response
Jessica A Pane, Vi T Dang, Gavan Holloway, Nicole L Webster, Barbara S Coulson
T cell-receptor transgenic NOD8.3 mice provide a model for spontaneous type 1 diabetes development. Infection of 5 week-old NOD8.3..
Relative Roles of GM1 Ganglioside, N-Acylneuraminic Acids, and alpha 2 beta 1 Integrin in Mediating Rotavirus Infection
Fiona E Fleming, Raphael Boehm, Vi T Dang, Gavan Holloway, Thomas Haselhorst, Paul D Madge, Jaigeeth Deveryshetty, Xing Yu, Helen Blanchard, Mark von Itzstein, Barbara S Coulson
UNLABELLED: N-acetyl- and N-glycolylneuraminic acids (Sia) and α2β1 integrin are frequently used by rotaviruses as cellular recept..
Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells
Jessica A Pane, Nicole L Webster, Barbara S Coulson
It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a c..
Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells
Jessica A Pane, Nicole L Webster, Christel Zufferey, Barbara S Coulson
Rotavirus infection has been proposed to enhance progression towards type 1 diabetes in at-risk children. Rhesus monkey rotavirus ..
Alteration of the Thymic T Cell Repertoire by Rotavirus Infection Is Associated with Delayed Type 1 Diabetes Development in Non-Obese Diabetic Mice
Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson
Rotaviruses are implicated as a viral trigger for the acceleration of type 1 diabetes in children. Infection of adult non-obese di..
Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes
JA Pane, NL Webster, KL Graham, G Holloway, C Zufferey, BS Coulson
AIMS/HYPOTHESIS: Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 d..
Structural Basis of Rotavirus Strain Preference toward N-Acetyl- or N-Glycolylneuraminic Acid-Containing Receptors
Xing Yu, Vi T Dang, Fiona E Fleming, Mark von Itzstein, Barbara S Coulson, Helen Blanchard
The rotavirus spike protein domain VP8* is essential for recognition of cell surface carbohydrate receptors, notably those incorpo..
Novel Structural Insights into Rotavirus Recognition of Ganglioside Glycan Receptors
Xing Yu, Barbara S Coulson, Fiona E Fleming, Jeffrey C Dyason, Mark von Itzstein, Helen Blanchard
Rotaviruses ubiquitously infect children under the age of 5, being responsible for more than half a million diarrhoeal deaths each..
Determinants of the Specificity of Rotavirus Interactions with the alpha 2 beta 1 Integrin
Fiona E Fleming, Kate L Graham, Yoshikazu Takada, Barbara S Coulson
The human α2β1 integrin binds collagen and acts as a cellular receptor for rotaviruses and human echovirus 1. These ligands requir..