RESEARCH FELLOWSHIP - ASSOC PROF BARBARA COULSON

Grant number: 628319 | Funding period: 2010 - 2015

Completed

Abstract

I am a virologist carrying out research to determine the mechanisms underlying rotavirus cellular tropism and the pathogenesis of rotavirus disease. Rotavirus is the major cause of infantile gastroenteritis worldwide. I am combining the expertise of my group in rotavirus biology with the power of inter-disciplinary collaborations in the areas of sugar chemistry, cell biology, structural biology and diabetes to expand understanding in these areas. Novel treatments and improvements in rotavirus vaccines are the long term goal of our research.

Related publications (8)

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Inside Cover: Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection (ChemBioChem 15/2015)

Xing Yu, Rahul Mishra, Gavan Holloway, Mark von Itzstein, Barbara S Coulson, Helen Blanchard

2015-10-01

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NSP1 of human rotaviruses commonly inhibits NF-kappa B signalling by inducing beta-TrCP degradation

Izabel JM Di Fiore, Jessica A Pane, Gavan Holloway, Barbara S Coulson

2015-07-01

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Relative Roles of GM1 Ganglioside, N-Acylneuraminic Acids, and alpha 2 beta 1 Integrin in Mediating Rotavirus Infection

Fiona E Fleming, Raphael Boehm, Vi T Dang, Gavan Holloway, Thomas Haselhorst, Paul D Madge, Jaigeeth Deveryshetty, Xing Yu, Helen Blanchard, Mark von Itzstein, Barbara S Coulson

2014-04-01

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Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A Pane, Nicole L Webster, Barbara S Coulson

2014-03-01

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Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells

Jessica A Pane, Nicole L Webster, Christel Zufferey, Barbara S Coulson

2014-01-22

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Alteration of the Thymic T Cell Repertoire by Rotavirus Infection Is Associated with Delayed Type 1 Diabetes Development in Non-Obese Diabetic Mice

Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson

2013-03-15

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Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes

JA Pane, NL Webster, KL Graham, G Holloway, C Zufferey, BS Coulson

2013-03-01

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Structural Basis of Rotavirus Strain Preference toward N-Acetyl- or N-Glycolylneuraminic Acid-Containing Receptors

Xing Yu, Vi T Dang, Fiona E Fleming, Mark von Itzstein, Barbara S Coulson, Helen Blanchard

2012-12-01