RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS
Grant number: 628386 | Funding period: 2010 - 2015
I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research chair with the specific aim of leading a team of researchers in neuropsychiatric research. One of the goals of the Centre is to deliver world-class neuroimaging research in psychiatric disorders. I head a team of researchers that have been undertaking neuroimaging and neuropsychological work on schizophrenia and psychosis since 1993 in Australia. My particular interest and impact on the field has been to define and understand progressive brain changes in schizophrenia and related psychotic disorders. Further work will place these changes within a brain mat..View full description
Related publications (141)
Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.
Rachele Sanfelici, Anne Ruef, Linda A Antonucci, Nora Penzel, Aristeidis Sotiras, Mark Sen Dong, Maria Urquijo-Castro, Julian Wenzel, Lana Kambeitz-Ilankovic, Meike D Hettwer, Stephan Ruhrmann, Katharine Chisholm, Anita Riecher-Rössler, Peter Falkai, Christos Pantelis, Raimo KR Salokangas, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Eva Meisenzahl
Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatri..
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.
James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen
The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disord..
Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes
David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi
BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..
Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz
BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra..
Validation of the Bullying Scale for Adults - Results of the PRONIA-study
Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz
BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..
Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA
Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..
Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors
Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky
In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..
The genetic architecture of the human cerebral cortex
Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..
Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study
Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis
Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..
The Impact of Childhood Adversity on Cognitive Development in Schizophrenia
Ruth Wells, Isabella Jacomb, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg, Jason Bruggemann, Vanessa Cropley, Rhoshel K Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Cynthia Shannon Weickert, Thomas W Weickert
Childhood adversity, such as physical, sexual, and verbal abuse, as well as neglect and family conflict, is a risk factor for schi..
Common mechanisms of executive attention underlie executive function and effortful control in children
Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa
Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..
Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort
Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns
OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this c..
Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..
Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation
Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell
OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..
Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky
OBJECTIVE: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesiz..
Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network
Akhil Kottaram, Leigh A Johnston, Luca Cocchi, Eleni P Ganella, Ian Everall, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky
Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain net..
Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)
Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno
Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated w..
Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia
Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall
Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation ..
Investigation of peripheral complement factors across stages of psychosis
Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A Di Biase, Gursharan Chana, Bernhard T Baune, Chad Bousman, Barnaby Nelson, Patrick McGorry, Ian Everall, Christos Pantelis, Vanessa Cropley
The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether p..
An fMRI study of theory of mind in individuals with first episode psychosis
Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood
Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..
Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study
Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz
INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..
Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis
Akhil Kottaram, Leigh Johnston, Eleni Ganella, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky
Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is a..
Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia
Edith J Chau, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Christos Pantelis, Chad A Bousman, Ian P Everall
Upregulation of selenium binding protein 1 (SELENBP1) mRNA expression has been reported in schizophrenia, primarily in the dorsola..
Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis
K Allott, D Fraguas, CF Bartholomeusz, CM Diaz-Caneja, C Wannan, EM Parrish, GP Amminger, C Pantelis, C Arango, PD McGorry, M Rapado-Castro
BACKGROUND: Previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (DUP) an..
Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia
CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis
BACKGROUND: Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been as..
Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania
Orwa Dandash, Murat Yucel, Rothanthi Daglas, Christos Pantelis, Patrick McGorry, Michael Berk, Alex Fornito
Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and q..
Predictors and consequences of health anxiety symptoms: a novel twin modeling study
C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison
OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..
Risk and resilience brain networks in treatment-resistant schizophrenia
Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..
Symptom recovery and relationship to structure of corpus callosum in individuals with an 'at risk mental state'
Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno
Previous studies have revealed that changes in sub-threshold psychotic symptoms observed in individuals with an 'at risk mental st..
Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack
The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knoc..
Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls
Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky
Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..
Attentional set-shifting and social abilities in children with schizotypal and comorbid autism spectrum disorders
Ahmad Abu-Akel, Renee R Testa, Harvey P Jones, Nola Ross, Efstratios Skafidas, Bruce Tonge, Christos Pantelis
OBJECTIVE: While diagnostically independent, autism and schizotypal disorders can co-occur. Their concurrent impact on outcomes an..
Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study
CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood
BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..
Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients
Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman
Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mo..
No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism
Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chana
Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes h..
White matter connectivity disruptions in early and chronic schizophrenia
MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky
BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley
We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..
Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence
Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen
Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..
Functional brain networks in treatment-resistant schizophrenia
Eleni P Ganella, Cali F Bartholomeusz, Caio Seguin, Sarah Whittle, Chad Bousman, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
INTRODUCTION: Up to 20% of individuals with schizophrenia show minimal or no response to medication and are considered to have 'tr..
Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial
Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton
BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their effic..
A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability
Felicity Klopper, Renee Testa, Christos Pantelis, Efstratios Skafidas
Background The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without inte..
Lithium suppression of tau induces brain iron accumulation and neurodegeneration
P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush
Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..
Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis
Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood
Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..
Substance use in youth at risk for psychosis
R Carney, AR Yung, GP Amminger, T Bradshaw, N Glozier, DF Hermens, IB Hickie, E Killackey, P McGorry, C Pantelis, SJ Wood, R Purcell
BACKGROUND: People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. ..
White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs
Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky
White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..
Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations
C Liu, CA Bousman, C Pantelis, E Skafidas, D Zhang, W Yue, IP Everall
Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousa..
Neuroprotection after a first episode of mania: a randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume
M Berk, O Dandash, R Daglas, SM Cotton, K Allott, A Fornito, C Suo, P Klauser, B Liberg, L Henry, C Macneil, M Hasty, P McGorry, Cs Pantelis, M Yucel
Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain..
Multi-center MRI prediction models: Predicting sex and illness course in first episode psychosis patients
Mireille Nieuwenhuis, Hugo G Schnack, Neeltje E van Haren, Julia Lappin, Craig Morgan, Antje A Reinders, Diana Gutierrez-Tordesillas, Roberto Roiz-Santianez, Maristela S Schaufelberger, Pedro G Rosa, Marcus V Zanetti, Geraldo F Busatto, Benedicto Crespo-Facorro, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood, Rene S Kahn, Janaina Mourao-Miranda, Paola Dazzan
Structural Magnetic Resonance Imaging (MRI) studies have attempted to use brain measures obtained at the first-episode of psychosi..
Effects of cigarette smoking on cortical thickness in major depressive disorder
Nabi Zorlu, Vanessa Louise Cropley, Pelin Kurtgoz Zorlu, Dursun Hakan Delibas, Zehra Hilal Adibelli, Emel Pasa Baskin, Ozgur Sipahi Esen, Emre Bora, Christos Pantelis
Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smok..
Abnormal white matter integrity in synthetic cannabinoid users
Nabi Zorlu, Maria Angelique Di Biase, Cigdem Colak Kalayci, Andrew Zalesky, Basak Bagci, Nihan Oguz, Fazil Gelal, Lutfullah Besiroglu, Seref Gulseren, Aybala Saricicek, Emre Bora, Christos Pantelis
Synthetic cannabinoids have become increasingly popular in the last few years especially among adolescents and young adults. Howev..
A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults
Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) sta..
Olfactory sulcus morphology in patients with current and past major depression
Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen
Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is assoc..
Neuregulin-1 and schizophrenia in the genome-wide association study era
Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousman
Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical component in the pathophysiology of schizophre..
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger
BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..
Early origins of mental disorder - risk factors in the perinatal and infant period
Louise Newman, Fiona Judd, Craig A Olsson, David Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M Craig, Angela Komiti, Ian Everall
BACKGROUND: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of ..
A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis
Justin Davis, Harris Eyre, Felice N Jacka, Seetal Dodd, Olivia Dean, Sarah McEwen, Monojit Debnath, John McGrath, Michael Maes, Paul Amminger, Patrick D McGorry, Christos Pantelis, Michael Berk
Schizophrenia risk has often been conceptualized using a model which requires two hits in order to generate the clinical phenotype..
Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up
Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis
Meta-analysis of social cognition in attention-deficit/hyperactivity disorder (ADHD): comparison with healthy controls and autistic spectrum disorder
E Bora, C Pantelis
BACKGROUND: Impairment in social cognition is an established finding in autism spectrum disorders (ASD). Emerging evidence suggest..
Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting
Ian H Harding, Ben J Harrison, Michael Breakspear, Christos Pantelis, Murat Yuecel
Cognitive control (CC) and working memory (WM) are concurrently necessary for adaptive human behavior. These processes are thought..
Microglial activation and progressive brain changes in schizophrenia
LE Laskaris, MA Di Biase, I Everall, G Chana, A Christopoulos, E Skafidas, VL Cropley, C Pantelis
Schizophrenia is a debilitating disorder that typically begins in adolescence and is characterized by perceptual abnormalities, de..
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a
Benjamin J Shields, Jacob T Jackson, Donald Metcalf, Wei Shi, Qiutong Huang, Alexandra L Garnham, Stefan P Glaser, Dominik Beck, John E Pimanda, Clifford W Bogue, Gordon K Smyth, Warren S Alexander, Matthew P McCormack
Unlike clustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukemogenesis has not been..
Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study
Clara Lopez-Sola, Leonardo F Fontenelle, Minh Bui, John L Hopper, Christos Pantelis, Murat Yuecel, Jose M Menchon, Pino Alonso, Ben J Harrison
BACKGROUND: The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including obsessive-compulsive disord..
Altered corticostriatal functional connectivity in individuals with high social anhedonia
Y Wang, W-H Liu, Z Li, X-H Wei, X-Q Jiang, F-L Geng, L-Q Zou, SSY Lui, EFC Cheung, C Pantelis, RCK Chan
BACKGROUND: Dysregulation of the striatum and altered corticostriatal connectivity have been associated with psychotic disorders. ..
A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study
R Daglas, SM Cotton, K Allott, M Yuecel, CA Macneil, MK Hasty, B Murphy, C Pantelis, KT Hallam, LP Henry, P Conus, A Ratheesh, L Kader, M Th Wong, PD McGorry, M Berk
BACKGROUND: Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on ..
Demographic and clinical characteristics of young people seeking help at youth mental health services: baseline findings of the Transitions Study
Rosemary Purcell, Anthony F Jorm, Ian B Hickie, Alison R Yung, Christos Pantelis, G Paul Amminger, Nick Glozier, Eoin Killackey, Lisa J Phillips, Stephen J Wood, Susy Harrigan, Andrew Mackinnon, Elizabeth Scott, Daniel F Hermens, Adam J Guastella, Amanda Kenyon, Laura Mundy, Alissa Nichles, Antoinette Scaffidi, Daniela Spiliotacopoulos
AIM: The Transitions Study was designed to establish a cohort of young people (12-25 years) seeking help for mental health problem..
Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia
Vanessa L Cropley, Cali E Bartholomeusz, Peter Wu, Stephen J Wood, Tina Proffitt, Warrick J Brewer, Patricia M Desmond, Dennis Velakoulis, Christos Pantelis
Abnormalities of orbitofrontal cortex (OFC) pattern type distribution have been associated with schizophrenia-spectrum disorders. ..
The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia
Vanessa L Cropley, Elizabeth Scarr, Alex Fornito, Paul Klauser, Chad A Bousman, Rodney Scott, Murray J Cairns, Paul A Tooney, Christos Pantelis, Brian Dean
Previous research has demonstrated that individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymo..
Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia
Cali F Bartholomeusz, Eleni P Ganella, Izelle Labuschagne, Chad Bousman, Christos Pantelis
Impairments in social cognition and poor social functioning are core features of schizophrenia-spectrum disorders. In recent years..
Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications
Gursharan Chana, Liliana Laskaris, Christos Pantelis, Piers Gillett, Renee Testa, Daniela Zantomio, Emma L Burrows, Anthony J Hannan, Ian P Everall, Efstratios Skafidas
Metabotropic glutamate receptor 5 (mGluR5) and microglial abnormalities have been implicated in autism spectrum disorder (ASD). Ho..
Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings
Andrew Zalesky, Christos Pantelis, Vanessa Cropley, Alex Fornito, Luca Cocchi, Harrison McAdams, Liv Clasen, Deanna Greenstein, Judith L Rapoport, Nitin Gogtay
IMPORTANCE: Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnorm..
Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls
Emre Bora, Christos Pantelis
Neurocognitive deficits are evident both in established schizophrenia and bipolar disorder (BP). However, it has been suggested th..
Cognitive intervention in early psychosis - preserving abilities versus remediating deficits
Christos Pantelis, Cassandra Wannan, Cali F Bartholomeusz, Kelly Allott, Patrick D McGorry
Remediation strategies have focused on a deficits model to plan restorative interventions, with inconsistent results. Here, we pro..
Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for Psychosis
Kareen Heinze, Renate LEP Reniers, Barnaby Nelson, Alison R Yung, Ashleigh Lin, Ben J Harrison, Christos Pantelis, Dennis Velakoulis, Patrick D McGorry, Stephen J Wood
BACKGROUND: Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse..
Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD
Daniela Zantomio, Gursharan Chana, Liliana Laskaris, Renee Testa, Ian Everall, Christos Pantelis, Efstratios Skafidas
The pathogenesis of Autism Spectrum Disorder (ASD), a serious neurodevelopmental disorder, is poorly understood. We review evidenc..
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice
BJ Shields, R Alserihi, C Nasa, C Bogue, WS Alexander, MP McCormack
Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute leukemias, in particular poor prognosis..
A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS)
Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Andrew Zalesky, Masaaki Hori, Keigo Shimoji, Junichi Saito, Shinya Ito, Dominic B Dwyer, Issei Fukunaga, Keiko Morita, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
BACKGROUND: Evidence supports disruption in white matter (WM) connectivity in established schizophrenia, however, it is unclear wh..
Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity
Yi Wang, Chao Yan, Da-zhi Yin, Ming-xia Fan, Eric FC Cheung, Christos Pantelis, Raymond CK Chan
The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks deriv..
The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment
Renate LEP Reniers, Belinda Garner, Christina Phassouliotis, Lisa J Phillips, Connie Markulev, Christos Pantelis, Sarah Bendall, Patrick D McGorry, Stephen J Wood
Stress and abnormal hypothalamic-pituitary-adrenal axis functioning have been implicated in the early phase of psychosis and may p..
Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis
BRE Ansell, DB Dwyer, SJ Wood, E Bora, WJ Brewer, TM Proffitt, D Velakoulis, PD McGorry, C Pantelis
BACKGROUND: Whether there are differential effects of first-generation antipsychotics (FGAs) and second-generation antipsychotics ..
Effective connectivity within the frontoparietal control network differentiates cognitive control and working memory
Ian H Harding, Murat Yuecel, Ben J Harrison, Christos Pantelis, Michael Breakspear
Cognitive control and working memory rely upon a common fronto-parietal network that includes the inferior frontal junction (IFJ),..
A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis
Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas D Huntington, Clifford W Bogue, Warren S Alexander, Matthew P McCormack
The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hem..
Gross morphological brain changes with chronic, heavy cannabis use
Valentina Lorenzetti, Nadia Solowij, Sarah Whittle, Alex Fornito, Dan I Lubman, Christos Pantelis, Murat Yuecel
We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric..
The impact of premorbid and current intellect in schizophrenia: cognitive, symptom, and functional outcomes
Ruth Wells, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg, Jason Bruggemann, Isabella Jacomb, Vanessa Cropley, Rhoshel Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Cynthia Shannon Weickert, Thomas W Weickert
BACKGROUND: Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelli..
The Melbourne Assessment of Schizotypy in Kids: A Useful Measure of Childhood Schizotypal Personality Disorder
Harvey P Jones, Renee R Testa, Nola Ross, Marc L Seal, Christos Pantelis, Bruce Tonge
Despite being identified as a high risk cohort for psychosis, there has been relatively little research on the clinical presentati..
Relationship between amygdala volume and emotion recognition in adolescents at ultra-high risk for psychosis
Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Kelly Allott, Simon Rice, Miriam R Schaefer, Christos Pantelis, G Paul Amminger
Amygdala volume has been proposed as a neural risk biomarker for psychotic illness, but findings in the ultra-high risk for psycho..
Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances
Benny Liberg, Paul Klauser, Ian H Harding, Mats Adler, Christoffer Rahm, Johan Lundberg, Thomas Masterman, Caroline Wachtler, Tomas Jonsson, Maria Kristoffersen-Wiberg, Christos Pantelis, Bjorn Wahlund
Psychomotor disturbances are a classic feature of major depressive disorders. These can manifest as lack of facial expressions and..
Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis
Sung-Wan Kim, Miriam R Schaefer, Claudia M Klier, Michael Berk, Simon Rice, Kelly Allott, Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Christos Pantelis, Patrick D McGorry, G Paul Amminger
Cognitive symptoms and impairment are central to schizophrenia and often an early sign of this condition. The present study invest..
Altered Striatal Functional Connectivity in Subjects With an At-Risk Mental State for Psychosis
Orwa Dandash, Alex Fornito, Jimmy Lee, Richard SE Keefe, Michael WL Chee, R Alison Adcock, Christos Pantelis, Stephen J Wood, Ben J Harrison
Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal stri..
Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis
E Bora, A Lin, SJ Wood, AR Yung, PD McGorry, C Pantelis
OBJECTIVE: It is likely that cognitive deficits are vulnerability markers for developing schizophrenia, as these deficits are alre..
Prevalence and Heritability of Obsessive-Compulsive Spectrum and Anxiety Disorder Symptoms: A Survey of the Australian Twin Registry
Clara Lopez-Sola, Leonardo F Fontenelle, Pino Alonso, Daniel Cuadras, Debra L Foley, Christos Pantelis, Jesus Pujol, Murat Yuecel, Narcis Cardoner, Carles Soriano-Mas, Jose M Menchon, Ben J Harrison
While past twin studies indicate moderate levels of heritability of "obsessive-compulsive related" and anxiety disorder symptoms, ..
Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis
Qing Zhao, Zhi Li, Jia Huang, Chao Yan, Paola Dazzan, Christos Pantelis, Eric FC Cheung, Simon SY Lui, Raymond CK Chan
BACKGROUND: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been convent..
Structural Brain Development and Depression Onset During Adolescence: A Prospective Longitudinal Study
Sarah Whittle, Renee Lichter, Meg Dennison, Nandita Vijayakumar, Orli Schwartz, Michelle L Byrne, Julian G Simmons, Murat Yuecel, Christos Pantelis, Patrick McGorry, Nicholas B Allen
OBJECTIVE: The authors sought to investigate whether the structural development of limbic, striatal, and prefrontal regions that a..
Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis
Suzie Lavoie, Cali F Bartholomeuz, Barnaby Nelson, Ashleigh Lin, Patrick D McGorry, Dennis Velakoulis, Sarah L Whittle, Alison R Yung, Christos Pantelis, Stephen J Wood
Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of ..
Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders
Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Murat Yuecel, Lisa J Phillips, Yumiko Nakamura, Michio Suzuki, Warrick J Brewer, Tina M Proffitt, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
A shallow olfactory sulcus has been reported in schizophrenia, possibly reflecting abnormal forebrain development during early ges..
Delayed sleep onset in depressed young people
Nicholas Glozier, Bridianne O'Dea, Patrick D McGorry, Christos Pantelis, Gunter Paul Amminger, Daniel F Hermens, Rosemary Purcell, Elizabeth Scott, Ian B Hickie
BACKGROUND: The circadian abnormality of delayed sleep phase has been suggested to characterise a subgroup of depressed young adul..
Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis
S Tognin, A Riecher-Roessler, EM Meisenzahl, SJ Wood, C Hutton, SJ Borgwardt, N Koutsouleris, AR Yung, P Allen, LJ Phillips, PD McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli
BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have..
Disruption of structure-function coupling in the schizophrenia connectome
Luca Cocchi, Ian H Harding, Anton Lord, Christos Pantelis, Murat Yucel, Andrew Zalesky
Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functi..
Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: A longitudinal study from 12 to 17 years of age
Michael Kaess, Julian G Simmons, Sarah Whittle, Martina Jovev, Andrew M Chanen, Murat Yuecel, Christos Pantelis, Nicholas B Allen
OBJECTIVE: To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituit..
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL
Matthew P McCormack, Benjamin J Shields, Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas J Slater, Cedric S Tremblay, Terence H Rabbitts, David J Curtis
Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), includi..
Childhood Maltreatment and Psychopathology Affect Brain Development During Adolescence
Sarah Whittle, Meg Dennison, Nandita Vijayakumar, Julian G Simmons, Murat Yuecel, Dan I Lubman, Christos Pantelis, Nicholas B Allen
OBJECTIVE: The hippocampus and amygdala have received much attention with regard to the deleterious effects of childhood maltreatm..
Markers of brain illness may be hidden in your olfactory ability: A Japanese perspective
Yuri Masaoka, Christos Pantelis, Anthony Phillips, Mitsuru Kawamura, Masaru Mimura, Genshin Minegishi, Ikuo Homma
There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory percep..
Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis
Cali F Bartholomeusz, Sarah L Whittle, Alice Montague, Brendan Ansell, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood
Three types of OFC sulcogyral patterns have been identified in the general population. The distribution of these three types has b..
Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: Systematic review and meta-analysis
Emre Bora, Christos Pantelis
Theory of mind (ToM) deficit is a well-established feature of schizophrenia and has been suggested as a vulnerability marker of th..
Applying clinical staging to young people who present for mental health care
Ian B Hickie, Elizabeth M Scott, Daniel F Hermens, Sharon L Naismith, Adam J Guastella, Manreena Kaur, Anna Sidis, Bradley Whitwell, Nicholas Glozier, Tracey Davenport, Christos Pantelis, Stephen J Wood, Patrick D McGorry
AIM: The study aims to apply clinical staging to young people who present for mental health care; to describe the demographic feat..
Alteration to hippocampal shape in cannabis users with and without schizophrenia
Nadia Solowij, Mark Walterfang, Dan I Lubman, Sarah Whittle, Valentina Lorenzetti, Martin Styner, Dennis Velakoulis, Christos Pantelis, Murat Yuecel
Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users...
A magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: Melancholic versus psychotic depression
Konstantina Vassilopoulou, Matilda Papathanasiou, Ioannis Michopoulos, Fotini Boufidou, Panagiotis Oulis, Nikolaos Kelekis, Emmanouil Rizos, Chrysoula Nikolaou, Christos Pantelis, Dennis Velakoulis, Lefteris Lykouras
BACKGROUND: Volumetric studies examining brain structure in depression subtypes are limited and inconclusive. The aim of the curre..
Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder
Leonardo F Fontenelle, Ben J Harrison, Jesus Pujol, Christopher G Davey, Alex Fornito, Emre Bora, Christos Pantelis, Murat Yuecel
BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining sympt..
Effect of long-term cannabis use on axonal fibre connectivity
Andrew Zalesky, Nadia Solowij, Murat Yuecel, Dan I Lubman, Michael Takagi, Ian H Harding, Valentina Lorenzetti, Ruopeng Wang, Karissa Searle, Christos Pantelis, Marc Seal
Cannabis use typically begins during adolescence and early adulthood, a period when cannabinoid receptors are still abundant in wh..
Frontal delta power associated with negative symptoms in ultra-high risk individuals who transitioned to psychosis
Suzie Lavoie, Miriam R Schaefer, Thomas J Whitford, Franz Benninger, Martha Feucht, Claudia M Klier, Hok Pan Yuen, Christos Pantelis, Patrick D McGorry, G Paul Amminger
It has recently been shown that treatment with long-chain omega-3 polyunsaturated fatty acids (PUFAs) could decrease the rate of t..
Functional Connectivity in Brain Networks Underlying Cognitive Control in Chronic Cannabis Users
Ian H Harding, Nadia Solowij, Ben J Harrison, Michael Takag, Valentina Lorenzetti, Dan I Lubman, Marc L Seal, Christos Pantelis, Murat Yuecel
The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control a..
New rather than old? For working memory tasks with abstract patterns the P3 and the single-trial delta response are larger for modified than identical probe stimuli
B Mathes, J Schmiedt, C Schmiedt-Fehr, C Pantelis, C Basar-Eroglu
Memory-guided decision making is dynamic and context-dependent, even though many studies describe an enhancement of the P3 for rec..
Gray matter abnormalities in Major Depressive Disorder: A meta-analysis of voxel based morphometry studies
Emre Bora, Alex Fornito, Christos Pantelis, Murat Yuecel
BACKGROUND: Voxel-based morphometry (VBM) has been widely used to quantify structural brain changes associated with Major Depressi..
Size and shape of the caudate nucleus in individuals with bipolar affective disorder
Daniel Ong, Mark Walterfang, Gin S Malhi, Martin Styner, Dennis Velakoulis, Christos Pantelis
OBJECTIVE: The caudate nucleus (CN) is a crucial component of the ventral striatum, which is part of a prefrontal-striatal-thalami..
The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample
Murat Yuecel, Emre Bora, Dan I Lubman, Nadia Solowij, Warrick J Brewer, Sue M Cotton, Philippe Conus, Michael J Takagi, Alex Fornito, Stephen J Wood, Patrick D McGorry, Christos Pantelis
Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the ..
The effects of gender on grey matter abnormalities in major psychoses: a comparative voxelwise meta-analysis of schizophrenia and bipolar disorder
E Bora, A Fornito, M Yuecel, C Pantelis
BACKGROUND: Recent evidence from genetic and familial studies revitalized the debate concerning the validity of the distinction be..
Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder
Esther Blessing, Linda Kader, Reza Arpandy, Youichirou Ootsuka, William W Blessing, Christos Pantelis
OBJECTIVE: Clinical studies suggest resting thermoregulatory cutaneous vasomotor tone could be increased in schizophrenia, resulti..
Understanding aberrant white matter development in schizophrenia: an avenue for therapy?
Mark Walterfang, Dennis Velakoulis, Thomas J Whitford, Christos Pantelis
Although historically gray matter changes have been the focus of neuropathological and neuroradiological studies in schizophrenia,..
Neuroanatomical abnormalities in schizophrenia: A multimodal voxelwise meta-analysis and meta-regression analysis
Emre Bora, Alex Fornito, Joaquim Radua, Mark Walterfang, Marc Seal, Stephen J Wood, Murat Yuecel, Dennis Velakoulis, Christos Pantelis
Despite an increasing number of published voxel based morphometry studies of schizophrenia, there has been no adequate attempt to ..
Disrupted Axonal Fiber Connectivity in Schizophrenia
Andrew Zalesky, Alex Fornito, Marc L Seal, Luca Cocchi, Carl-Fredrik Westin, Edward T Bullmore, Gary F Egan, Christos Pantelis
BACKGROUND: Schizophrenia is believed to result from abnormal functional integration of neural processes thought to arise from abe..
Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study
Katrina L Hannan, Stephen J Wood, Alison R Yung, Dennis Velakoulis, Lisa J Phillips, Bridget Soulsby, Gregor Berger, Patrick D McGorry, Christos Pantelis
The aim of the present study was to investigate whether volumetric abnormalities of the caudate nuclei predate the onset of psycho..