RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

Psychotic Disorders

Naveen Thomas, Christos Pantelis

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.

Rachele Sanfelici, Anne Ruef, Linda A Antonucci, Nora Penzel, Aristeidis Sotiras, Mark Sen Dong, Maria Urquijo-Castro, Julian Wenzel, Lana Kambeitz-Ilankovic, Meike D Hettwer, Stephan Ruhrmann, Katharine Chisholm, Anita Riecher-Rössler, Peter Falkai, Christos Pantelis, Raimo KR Salokangas, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Eva Meisenzahl

2021-09-14

Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatri..

Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis

Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley

2021-08-31

Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..

A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.

James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen

2021-06-07

The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disord..

Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes

David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi

2020-12-01

BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..

Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?

Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz

2020-10-01

BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra..

Validation of the Bullying Scale for Adults - Results of the PRONIA-study

Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz

2020-10-01

BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley

2020-09-01

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..

Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors

Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky

2020-08-15

In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..

The genetic architecture of the human cerebral cortex

Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien

2020-03-20

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..

Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study

Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis

2020-03-18

Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..

The Impact of Childhood Adversity on Cognitive Development in Schizophrenia

Ruth Wells, Isabella Jacomb, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg, Jason Bruggemann, Vanessa Cropley, Rhoshel K Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Cynthia Shannon Weickert, Thomas W Weickert

2020-01-01

Childhood adversity, such as physical, sexual, and verbal abuse, as well as neglect and family conflict, is a risk factor for schi..

Common mechanisms of executive attention underlie executive function and effortful control in children

Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa

2019-11-26

Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..

Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort

Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns

2019-11-16

OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this c..

Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz

2019-10-01

BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..

Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation

Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell

2019-08-01

OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..

Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky

2019-07-01

OBJECTIVE: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesiz..

Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network

Akhil Kottaram, Leigh A Johnston, Luca Cocchi, Eleni P Ganella, Ian Everall, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2019-05-01

Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain net..

Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms

Ye Tian, Andrew Zalesky, Chad Bousman, Ian Everall, Christos Pantelis

2019-04-01

BACKGROUND: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigat..

Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)

Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno

2019-03-30

Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated w..

Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall

2019-02-19

Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation ..

Investigation of peripheral complement factors across stages of psychosis

Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A Di Biase, Gursharan Chana, Bernhard T Baune, Chad Bousman, Barnaby Nelson, Patrick McGorry, Ian Everall, Christos Pantelis, Vanessa Cropley

2019-02-01

The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether p..

Decreased peripheral TNF alpha (TNF-alpha) mRNA expression in patients with treatment-resistant schizophrenia

Md Shaki Mostaid, Christos Pantelis, Ian P Everall, Chad A Bousman

2018-12-01

An fMRI study of theory of mind in individuals with first episode psychosis

Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood

2018-11-30

Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..

Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz

2018-09-01

INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..

Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis

Akhil Kottaram, Leigh Johnston, Eleni Ganella, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2018-09-01

Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is a..

A Hierarchical Model of Inhibitory Control

Jeggan Tiego, Renee Testa, Mark A Bellgrove, Christos Pantelis, Sarah Whittle

2018-08-02

Inhibitory control describes the suppression of goal-irrelevant stimuli and behavioral responses. Current developmental taxonomies..

Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia

Edith J Chau, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Christos Pantelis, Chad A Bousman, Ian P Everall

2018-07-13

Upregulation of selenium binding protein 1 (SELENBP1) mRNA expression has been reported in schizophrenia, primarily in the dorsola..

Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis

K Allott, D Fraguas, CF Bartholomeusz, CM Diaz-Caneja, C Wannan, EM Parrish, GP Amminger, C Pantelis, C Arango, PD McGorry, M Rapado-Castro

2018-07-01

BACKGROUND: Previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (DUP) an..

Genetic variation in cytokine genes and risk for transition to psychosis among individuals at ultra-high risk

Chad A Bousman, Tae Young Lee, Minah Kim, Junhee Lee, Md Shaki Mostaid, Minji Bang, Suk Kyoon An, Ian P Everall, Christos Pantelis, Jun Soo Kwon

2018-05-01

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis

2018-04-01

BACKGROUND: Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been as..

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania

Orwa Dandash, Murat Yucel, Rothanthi Daglas, Christos Pantelis, Patrick McGorry, Michael Berk, Alex Fornito

2018-03-06

Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and q..

Predictors and consequences of health anxiety symptoms: a novel twin modeling study

C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison

2018-03-01

OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..

Risk and resilience brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2018-03-01

BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..

Symptom recovery and relationship to structure of corpus callosum in individuals with an 'at risk mental state'

Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno

2018-02-28

Previous studies have revealed that changes in sub-threshold psychotic symptoms observed in individuals with an 'at risk mental st..

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack

2018-02-27

The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knoc..

Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls

Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky

2018-01-22

Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..

Attentional set-shifting and social abilities in children with schizotypal and comorbid autism spectrum disorders

Ahmad Abu-Akel, Renee R Testa, Harvey P Jones, Nola Ross, Efstratios Skafidas, Bruce Tonge, Christos Pantelis

2018-01-01

OBJECTIVE: While diagnostically independent, autism and schizotypal disorders can co-occur. Their concurrent impact on outcomes an..

Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study

CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood

2018-01-01

BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..

Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients

Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman

2017-12-11

Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mo..

No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism

Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chana

2017-12-08

Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes h..

White matter connectivity disruptions in early and chronic schizophrenia

MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky

2017-12-01

BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia

MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley

2017-08-29

We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..

Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence

Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen

2017-08-01

Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..

Functional brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Cali F Bartholomeusz, Caio Seguin, Sarah Whittle, Chad Bousman, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2017-06-01

INTRODUCTION: Up to 20% of individuals with schizophrenia show minimal or no response to medication and are considered to have 'tr..

Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial

Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton

2017-06-01

BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their effic..

A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability

Felicity Klopper, Renee Testa, Christos Pantelis, Efstratios Skafidas

2017-04-01

Background The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without inte..

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush

2017-03-01

Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood

2017-03-01

Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..

Substance use in youth at risk for psychosis

R Carney, AR Yung, GP Amminger, T Bradshaw, N Glozier, DF Hermens, IB Hickie, E Killackey, P McGorry, C Pantelis, SJ Wood, R Purcell

2017-03-01

BACKGROUND: People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. ..

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky

2017-03-01

White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..

Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations

C Liu, CA Bousman, C Pantelis, E Skafidas, D Zhang, W Yue, IP Everall

2017-02-21

Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousa..

Dopamine, fronto-striato-thalamic circuits and risk for psychosis

Orwa Dandash, Christos Pantelis, Alex Fornito

2017-02-01

A series of parallel, integrated circuits link distinct regions of prefrontal cortex with specific nuclei of the striatum and thal..

Neuroprotection after a first episode of mania: a randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume

M Berk, O Dandash, R Daglas, SM Cotton, K Allott, A Fornito, C Suo, P Klauser, B Liberg, L Henry, C Macneil, M Hasty, P McGorry, Cs Pantelis, M Yucel

2017-01-24

Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain..

Multi-center MRI prediction models: Predicting sex and illness course in first episode psychosis patients

Mireille Nieuwenhuis, Hugo G Schnack, Neeltje E van Haren, Julia Lappin, Craig Morgan, Antje A Reinders, Diana Gutierrez-Tordesillas, Roberto Roiz-Santianez, Maristela S Schaufelberger, Pedro G Rosa, Marcus V Zanetti, Geraldo F Busatto, Benedicto Crespo-Facorro, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood, Rene S Kahn, Janaina Mourao-Miranda, Paola Dazzan

2017-01-15

Structural Magnetic Resonance Imaging (MRI) studies have attempted to use brain measures obtained at the first-episode of psychosi..

Effects of cigarette smoking on cortical thickness in major depressive disorder

Nabi Zorlu, Vanessa Louise Cropley, Pelin Kurtgoz Zorlu, Dursun Hakan Delibas, Zehra Hilal Adibelli, Emel Pasa Baskin, Ozgur Sipahi Esen, Emre Bora, Christos Pantelis

2017-01-01

Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smok..

Abnormal white matter integrity in synthetic cannabinoid users

Nabi Zorlu, Maria Angelique Di Biase, Cigdem Colak Kalayci, Andrew Zalesky, Basak Bagci, Nihan Oguz, Fazil Gelal, Lutfullah Besiroglu, Seref Gulseren, Aybala Saricicek, Emre Bora, Christos Pantelis

2016-11-01

Synthetic cannabinoids have become increasingly popular in the last few years especially among adolescents and young adults. Howev..

A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults

Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier

2016-10-01

PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) sta..

Olfactory sulcus morphology in patients with current and past major depression

Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen

2016-09-30

Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is assoc..

Neuregulin-1 and schizophrenia in the genome-wide association study era

Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P Everall, Chad A Bousman

2016-09-01

Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical component in the pathophysiology of schizophre..

White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids

Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger

2016-08-11

BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..

Social cognition in schizophrenia in comparison to bipolar disorder: A meta-analysis

Emre Bora, Christos Pantelis

2016-08-01

OBJECTIVE: Cognitive dysfunction is a common characteristic of both schizophrenia and bipolar disorder (BP). While these deficits ..

Early origins of mental disorder - risk factors in the perinatal and infant period

Louise Newman, Fiona Judd, Craig A Olsson, David Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M Craig, Angela Komiti, Ian Everall

2016-07-29

BACKGROUND: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of ..

Brain change trajectories that differentiate the major psychoses

Benny Liberg, Christoffer Rahm, Anita Panayiotou, Christos Pantelis

2016-07-01

BACKGROUND: Bipolar disorder and schizophrenia are highly heritable, often chronic and debilitating psychotic disorders that can b..

A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis

Justin Davis, Harris Eyre, Felice N Jacka, Seetal Dodd, Olivia Dean, Sarah McEwen, Monojit Debnath, John McGrath, Michael Maes, Paul Amminger, Patrick D McGorry, Christos Pantelis, Michael Berk

2016-06-01

Schizophrenia risk has often been conceptualized using a model which requires two hits in order to generate the clinical phenotype..

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis

2016-06-01

Meta-analysis of social cognition in attention-deficit/hyperactivity disorder (ADHD): comparison with healthy controls and autistic spectrum disorder

E Bora, C Pantelis

2016-03-01

BACKGROUND: Impairment in social cognition is an established finding in autism spectrum disorders (ASD). Emerging evidence suggest..

Cortical Representations of Cognitive Control and Working Memory Are Dependent Yet Non-Interacting

Ian H Harding, Ben J Harrison, Michael Breakspear, Christos Pantelis, Murat Yuecel

2016-02-01

Cognitive control (CC) and working memory (WM) are concurrently necessary for adaptive human behavior. These processes are thought..

Microglial activation and progressive brain changes in schizophrenia

LE Laskaris, MA Di Biase, I Everall, G Chana, A Christopoulos, E Skafidas, VL Cropley, C Pantelis

2016-02-01

Schizophrenia is a debilitating disorder that typically begins in adolescence and is characterized by perceptual abnormalities, de..

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

Benjamin J Shields, Jacob T Jackson, Donald Metcalf, Wei Shi, Qiutong Huang, Alexandra L Garnham, Stefan P Glaser, Dominik Beck, John E Pimanda, Clifford W Bogue, Gordon K Smyth, Warren S Alexander, Matthew P McCormack

2016-01-01

Unlike clustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukemogenesis has not been..

Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study

Clara Lopez-Sola, Leonardo F Fontenelle, Minh Bui, John L Hopper, Christos Pantelis, Murat Yuecel, Jose M Menchon, Pino Alonso, Ben J Harrison

2016-01-01

BACKGROUND: The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including obsessive-compulsive disord..

Altered corticostriatal functional connectivity in individuals with high social anhedonia

Y Wang, W-H Liu, Z Li, X-H Wei, X-Q Jiang, F-L Geng, L-Q Zou, SSY Lui, EFC Cheung, C Pantelis, RCK Chan

2016-01-01

BACKGROUND: Dysregulation of the striatum and altered corticostriatal connectivity have been associated with psychotic disorders. ..

A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study

R Daglas, SM Cotton, K Allott, M Yuecel, CA Macneil, MK Hasty, B Murphy, C Pantelis, KT Hallam, LP Henry, P Conus, A Ratheesh, L Kader, M Th Wong, PD McGorry, M Berk

2016-01-01

BACKGROUND: Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on ..

Meta-analysis of Theory of Mind (ToM) impairment in bipolar disorder

E Bora, C Bartholomeusz, C Pantelis

2016-01-01

BACKGROUND: Theory of mind (ToM) dysfunction is prominent in a number of psychiatric disorders, in particular, autism and schizoph..

Demographic and clinical characteristics of young people seeking help at youth mental health services: baseline findings of the Transitions Study

Rosemary Purcell, Anthony F Jorm, Ian B Hickie, Alison R Yung, Christos Pantelis, G Paul Amminger, Nick Glozier, Eoin Killackey, Lisa J Phillips, Stephen J Wood, Susy Harrigan, Andrew Mackinnon, Elizabeth Scott, Daniel F Hermens, Adam J Guastella, Amanda Kenyon, Laura Mundy, Alissa Nichles, Antoinette Scaffidi, Daniela Spiliotacopoulos

2015-12-01

AIM: The Transitions Study was designed to establish a cohort of young people (12-25 years) seeking help for mental health problem..

Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

Vanessa L Cropley, Cali E Bartholomeusz, Peter Wu, Stephen J Wood, Tina Proffitt, Warrick J Brewer, Patricia M Desmond, Dennis Velakoulis, Christos Pantelis

2015-11-30

Abnormalities of orbitofrontal cortex (OFC) pattern type distribution have been associated with schizophrenia-spectrum disorders. ..

The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia

Vanessa L Cropley, Elizabeth Scarr, Alex Fornito, Paul Klauser, Chad A Bousman, Rodney Scott, Murray J Cairns, Paul A Tooney, Christos Pantelis, Brian Dean

2015-11-30

Previous research has demonstrated that individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymo..

Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

Cali F Bartholomeusz, Eleni P Ganella, Izelle Labuschagne, Chad Bousman, Christos Pantelis

2015-11-01

Impairments in social cognition and poor social functioning are core features of schizophrenia-spectrum disorders. In recent years..

Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications

Gursharan Chana, Liliana Laskaris, Christos Pantelis, Piers Gillett, Renee Testa, Daniela Zantomio, Emma L Burrows, Anthony J Hannan, Ian P Everall, Efstratios Skafidas

2015-10-01

Metabotropic glutamate receptor 5 (mGluR5) and microglial abnormalities have been implicated in autism spectrum disorder (ASD). Ho..

Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings

Andrew Zalesky, Christos Pantelis, Vanessa Cropley, Alex Fornito, Luca Cocchi, Harrison McAdams, Liv Clasen, Deanna Greenstein, Judith L Rapoport, Nitin Gogtay

2015-09-01

IMPORTANCE: Abnormalities in structural brain connectivity have been observed in patients with schizophrenia. Mapping these abnorm..

Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls

Emre Bora, Christos Pantelis

2015-09-01

Neurocognitive deficits are evident both in established schizophrenia and bipolar disorder (BP). However, it has been suggested th..

Cognitive intervention in early psychosis - preserving abilities versus remediating deficits

Christos Pantelis, Cassandra Wannan, Cali F Bartholomeusz, Kelly Allott, Patrick D McGorry

2015-08-01

Remediation strategies have focused on a deficits model to plan restorative interventions, with inconsistent results. Here, we pro..

Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for Psychosis

Kareen Heinze, Renate LEP Reniers, Barnaby Nelson, Alison R Yung, Ashleigh Lin, Ben J Harrison, Christos Pantelis, Dennis Velakoulis, Patrick D McGorry, Stephen J Wood

2015-06-01

BACKGROUND: Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse..

Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD

Daniela Zantomio, Gursharan Chana, Liliana Laskaris, Renee Testa, Ian Everall, Christos Pantelis, Efstratios Skafidas

2015-05-01

The pathogenesis of Autism Spectrum Disorder (ASD), a serious neurodevelopmental disorder, is poorly understood. We review evidenc..

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice

BJ Shields, R Alserihi, C Nasa, C Bogue, WS Alexander, MP McCormack

2015-04-01

Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute leukemias, in particular poor prognosis..

A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS)

Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Andrew Zalesky, Masaaki Hori, Keigo Shimoji, Junichi Saito, Shinya Ito, Dominic B Dwyer, Issei Fukunaga, Keiko Morita, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno

2015-03-01

BACKGROUND: Evidence supports disruption in white matter (WM) connectivity in established schizophrenia, however, it is unclear wh..

Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity

Yi Wang, Chao Yan, Da-zhi Yin, Ming-xia Fan, Eric FC Cheung, Christos Pantelis, Raymond CK Chan

2015-03-01

The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks deriv..

The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment

Renate LEP Reniers, Belinda Garner, Christina Phassouliotis, Lisa J Phillips, Connie Markulev, Christos Pantelis, Sarah Bendall, Patrick D McGorry, Stephen J Wood

2015-02-28

Stress and abnormal hypothalamic-pituitary-adrenal axis functioning have been implicated in the early phase of psychosis and may p..

Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis

BRE Ansell, DB Dwyer, SJ Wood, E Bora, WJ Brewer, TM Proffitt, D Velakoulis, PD McGorry, C Pantelis

2015-02-01

BACKGROUND: Whether there are differential effects of first-generation antipsychotics (FGAs) and second-generation antipsychotics ..

Effective connectivity within the frontoparietal control network differentiates cognitive control and working memory

Ian H Harding, Murat Yuecel, Ben J Harrison, Christos Pantelis, Michael Breakspear

2015-02-01

Cognitive control and working memory rely upon a common fronto-parietal network that includes the inferior frontal junction (IFJ),..

A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis

Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas D Huntington, Clifford W Bogue, Warren S Alexander, Matthew P McCormack

2015-01-29

The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hem..

Gross morphological brain changes with chronic, heavy cannabis use

Valentina Lorenzetti, Nadia Solowij, Sarah Whittle, Alex Fornito, Dan I Lubman, Christos Pantelis, Murat Yuecel

2015-01-01

We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric..

The impact of premorbid and current intellect in schizophrenia: cognitive, symptom, and functional outcomes

Ruth Wells, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg, Jason Bruggemann, Isabella Jacomb, Vanessa Cropley, Rhoshel Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Cynthia Shannon Weickert, Thomas W Weickert

2015-01-01

BACKGROUND: Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelli..

The Melbourne Assessment of Schizotypy in Kids: A Useful Measure of Childhood Schizotypal Personality Disorder

Harvey P Jones, Renee R Testa, Nola Ross, Marc L Seal, Christos Pantelis, Bruce Tonge

2015-01-01

Despite being identified as a high risk cohort for psychosis, there has been relatively little research on the clinical presentati..

Relationship between amygdala volume and emotion recognition in adolescents at ultra-high risk for psychosis

Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Kelly Allott, Simon Rice, Miriam R Schaefer, Christos Pantelis, G Paul Amminger

2014-12-30

Amygdala volume has been proposed as a neural risk biomarker for psychotic illness, but findings in the ultra-high risk for psycho..

Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances

Benny Liberg, Paul Klauser, Ian H Harding, Mats Adler, Christoffer Rahm, Johan Lundberg, Thomas Masterman, Caroline Wachtler, Tomas Jonsson, Maria Kristoffersen-Wiberg, Christos Pantelis, Bjorn Wahlund

2014-12-04

Psychomotor disturbances are a classic feature of major depressive disorders. These can manifest as lack of facial expressions and..

Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis

Sung-Wan Kim, Miriam R Schaefer, Claudia M Klier, Michael Berk, Simon Rice, Kelly Allott, Cali F Bartholomeusz, Sarah L Whittle, Eleanor Pilioussis, Christos Pantelis, Patrick D McGorry, G Paul Amminger

2014-09-01

Cognitive symptoms and impairment are central to schizophrenia and often an early sign of this condition. The present study invest..

Altered Striatal Functional Connectivity in Subjects With an At-Risk Mental State for Psychosis

Orwa Dandash, Alex Fornito, Jimmy Lee, Richard SE Keefe, Michael WL Chee, R Alison Adcock, Christos Pantelis, Stephen J Wood, Ben J Harrison

2014-07-01

Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal stri..

Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis

E Bora, A Lin, SJ Wood, AR Yung, PD McGorry, C Pantelis

2014-07-01

OBJECTIVE: It is likely that cognitive deficits are vulnerability markers for developing schizophrenia, as these deficits are alre..

Prevalence and Heritability of Obsessive-Compulsive Spectrum and Anxiety Disorder Symptoms: A Survey of the Australian Twin Registry

Clara Lopez-Sola, Leonardo F Fontenelle, Pino Alonso, Daniel Cuadras, Debra L Foley, Christos Pantelis, Jesus Pujol, Murat Yuecel, Narcis Cardoner, Carles Soriano-Mas, Jose M Menchon, Ben J Harrison

2014-06-01

While past twin studies indicate moderate levels of heritability of "obsessive-compulsive related" and anxiety disorder symptoms, ..

Neurological Soft Signs Are Not "Soft" in Brain Structure and Functional Networks: Evidence From ALE Meta-Analysis

Qing Zhao, Zhi Li, Jia Huang, Chao Yan, Paola Dazzan, Christos Pantelis, Eric FC Cheung, Simon SY Lui, Raymond CK Chan

2014-05-01

BACKGROUND: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been convent..

Structural Brain Development and Depression Onset During Adolescence: A Prospective Longitudinal Study

Sarah Whittle, Renee Lichter, Meg Dennison, Nandita Vijayakumar, Orli Schwartz, Michelle L Byrne, Julian G Simmons, Murat Yuecel, Christos Pantelis, Patrick McGorry, Nicholas B Allen

2014-05-01

OBJECTIVE: The authors sought to investigate whether the structural development of limbic, striatal, and prefrontal regions that a..

Olfactory sulcus morphology in established bipolar affective disorder

Tsutomu Takahashi, Gin S Malhi, Yumiko Nakamura, Michio Suzuki, Christos Pantelis

2014-04-30

This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with b..

Predicting the diagnosis of autism spectrum disorder using gene pathway analysis

E Skafidas, R Testa, D Zantomio, G Chana, IP Everall, C Pantelis

2014-04-01

Autism spectrum disorder (ASD) depends on a clinical interview with no biomarkers to aid diagnosis. The current investigation inte..

Sulcogyral pattern and sulcal count of the orbitofrontal cortex in individuals at ultra high risk for psychosis

Suzie Lavoie, Cali F Bartholomeuz, Barnaby Nelson, Ashleigh Lin, Patrick D McGorry, Dennis Velakoulis, Sarah L Whittle, Alison R Yung, Christos Pantelis, Stephen J Wood

2014-04-01

Three types of orbitofrontal cortex (OFC) sulcogyral patterns have been identified in the general population. The distribution of ..

Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders

Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Murat Yuecel, Lisa J Phillips, Yumiko Nakamura, Michio Suzuki, Warrick J Brewer, Tina M Proffitt, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis

2014-03-01

A shallow olfactory sulcus has been reported in schizophrenia, possibly reflecting abnormal forebrain development during early ges..

Delayed sleep onset in depressed young people

Nicholas Glozier, Bridianne O'Dea, Patrick D McGorry, Christos Pantelis, Gunter Paul Amminger, Daniel F Hermens, Rosemary Purcell, Elizabeth Scott, Ian B Hickie

2014-02-08

BACKGROUND: The circadian abnormality of delayed sleep phase has been suggested to characterise a subgroup of depressed young adul..

Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

S Tognin, A Riecher-Roessler, EM Meisenzahl, SJ Wood, C Hutton, SJ Borgwardt, N Koutsouleris, AR Yung, P Allen, LJ Phillips, PD McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli

2014-02-01

BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have..

Disruption of structure-function coupling in the schizophrenia connectome

Luca Cocchi, Ian H Harding, Anton Lord, Christos Pantelis, Murat Yucel, Andrew Zalesky

2014-01-01

Neuroimaging studies have demonstrated that the phenomenology of schizophrenia maps onto diffuse alterations in large-scale functi..

Novel implications of Lingo-1 and its signaling partners in schizophrenia

F Fernandez-Enright, JL Andrews, KA Newell, C Pantelis, XF Huang

2014-01-01

Myelination and neurite outgrowth both occur during brain development, and their disturbance has been previously been implicated i..

Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: A longitudinal study from 12 to 17 years of age

Michael Kaess, Julian G Simmons, Sarah Whittle, Martina Jovev, Andrew M Chanen, Murat Yuecel, Christos Pantelis, Nicholas B Allen

2013-11-01

OBJECTIVE: To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituit..

Cognitive impairment in euthymic major depressive disorder: a meta-analysis

E Bora, BJ Harrison, M Yuecel, C Pantelis

2013-10-01

BACKGROUND: There is evidence to suggest that cognitive deficits might persist beyond the acute stages of illness in major depress..

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

Matthew P McCormack, Benjamin J Shields, Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas J Slater, Cedric S Tremblay, Terence H Rabbitts, David J Curtis

2013-09-19

Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), includi..

Childhood Maltreatment and Psychopathology Affect Brain Development During Adolescence

Sarah Whittle, Meg Dennison, Nandita Vijayakumar, Julian G Simmons, Murat Yuecel, Dan I Lubman, Christos Pantelis, Nicholas B Allen

2013-09-01

OBJECTIVE: The hippocampus and amygdala have received much attention with regard to the deleterious effects of childhood maltreatm..

Markers of brain illness may be hidden in your olfactory ability: A Japanese perspective

Yuri Masaoka, Christos Pantelis, Anthony Phillips, Mitsuru Kawamura, Masaru Mimura, Genshin Minegishi, Ikuo Homma

2013-08-09

There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory percep..

Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis

Cali F Bartholomeusz, Sarah L Whittle, Alice Montague, Brendan Ansell, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood

2013-07-01

Three types of OFC sulcogyral patterns have been identified in the general population. The distribution of these three types has b..

Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: Systematic review and meta-analysis

Emre Bora, Christos Pantelis

2013-03-01

Theory of mind (ToM) deficit is a well-established feature of schizophrenia and has been suggested as a vulnerability marker of th..

Applying clinical staging to young people who present for mental health care

Ian B Hickie, Elizabeth M Scott, Daniel F Hermens, Sharon L Naismith, Adam J Guastella, Manreena Kaur, Anna Sidis, Bradley Whitwell, Nicholas Glozier, Tracey Davenport, Christos Pantelis, Stephen J Wood, Patrick D McGorry

2013-02-01

AIM: The study aims to apply clinical staging to young people who present for mental health care; to describe the demographic feat..

Alteration to hippocampal shape in cannabis users with and without schizophrenia

Nadia Solowij, Mark Walterfang, Dan I Lubman, Sarah Whittle, Valentina Lorenzetti, Martin Styner, Dennis Velakoulis, Christos Pantelis, Murat Yuecel

2013-01-01

Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users...

A magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: Melancholic versus psychotic depression

Konstantina Vassilopoulou, Matilda Papathanasiou, Ioannis Michopoulos, Fotini Boufidou, Panagiotis Oulis, Nikolaos Kelekis, Emmanouil Rizos, Chrysoula Nikolaou, Christos Pantelis, Dennis Velakoulis, Lefteris Lykouras

2013-01-01

BACKGROUND: Volumetric studies examining brain structure in depression subtypes are limited and inconclusive. The aim of the curre..

Schizophrenia, neuroimaging and connectomics

Alex Fornito, Andrew Zalesky, Christos Pantelis, Edward T Bullmore

2012-10-01

Schizophrenia is frequently characterized as a disorder of brain connectivity. Neuroimaging has played a central role in supportin..

Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder

Leonardo F Fontenelle, Ben J Harrison, Jesus Pujol, Christopher G Davey, Alex Fornito, Emre Bora, Christos Pantelis, Murat Yuecel

2012-07-01

BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining sympt..

Effect of long-term cannabis use on axonal fibre connectivity

Andrew Zalesky, Nadia Solowij, Murat Yuecel, Dan I Lubman, Michael Takagi, Ian H Harding, Valentina Lorenzetti, Ruopeng Wang, Karissa Searle, Christos Pantelis, Marc Seal

2012-07-01

Cannabis use typically begins during adolescence and early adulthood, a period when cannabinoid receptors are still abundant in wh..

Frontal delta power associated with negative symptoms in ultra-high risk individuals who transitioned to psychosis

Suzie Lavoie, Miriam R Schaefer, Thomas J Whitford, Franz Benninger, Martha Feucht, Claudia M Klier, Hok Pan Yuen, Christos Pantelis, Patrick D McGorry, G Paul Amminger

2012-07-01

It has recently been shown that treatment with long-chain omega-3 polyunsaturated fatty acids (PUFAs) could decrease the rate of t..

Functional Connectivity in Brain Networks Underlying Cognitive Control in Chronic Cannabis Users

Ian H Harding, Nadia Solowij, Ben J Harrison, Michael Takag, Valentina Lorenzetti, Dan I Lubman, Marc L Seal, Christos Pantelis, Murat Yuecel

2012-07-01

The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control a..

New rather than old? For working memory tasks with abstract patterns the P3 and the single-trial delta response are larger for modified than identical probe stimuli

B Mathes, J Schmiedt, C Schmiedt-Fehr, C Pantelis, C Basar-Eroglu

2012-07-01

Memory-guided decision making is dynamic and context-dependent, even though many studies describe an enhancement of the P3 for rec..

Gray matter abnormalities in Major Depressive Disorder: A meta-analysis of voxel based morphometry studies

Emre Bora, Alex Fornito, Christos Pantelis, Murat Yuecel

2012-04-01

BACKGROUND: Voxel-based morphometry (VBM) has been widely used to quantify structural brain changes associated with Major Depressi..

Size and shape of the caudate nucleus in individuals with bipolar affective disorder

Daniel Ong, Mark Walterfang, Gin S Malhi, Martin Styner, Dennis Velakoulis, Christos Pantelis

2012-04-01

OBJECTIVE: The caudate nucleus (CN) is a crucial component of the ventral striatum, which is part of a prefrontal-striatal-thalami..

The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample

Murat Yuecel, Emre Bora, Dan I Lubman, Nadia Solowij, Warrick J Brewer, Sue M Cotton, Philippe Conus, Michael J Takagi, Alex Fornito, Stephen J Wood, Patrick D McGorry, Christos Pantelis

2012-03-01

Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the ..

The effects of gender on grey matter abnormalities in major psychoses: a comparative voxelwise meta-analysis of schizophrenia and bipolar disorder

E Bora, A Fornito, M Yuecel, C Pantelis

2012-02-01

BACKGROUND: Recent evidence from genetic and familial studies revitalized the debate concerning the validity of the distinction be..

Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder

Esther Blessing, Linda Kader, Reza Arpandy, Youichirou Ootsuka, William W Blessing, Christos Pantelis

2011-08-01

OBJECTIVE: Clinical studies suggest resting thermoregulatory cutaneous vasomotor tone could be increased in schizophrenia, resulti..

Understanding aberrant white matter development in schizophrenia: an avenue for therapy?

Mark Walterfang, Dennis Velakoulis, Thomas J Whitford, Christos Pantelis

2011-07-01

Although historically gray matter changes have been the focus of neuropathological and neuroradiological studies in schizophrenia,..

Age of Onset of Schizophrenia: Perspectives From Structural Neuroimaging Studies

Nitin Gogtay, Nora S Vyas, Renee Testa, Stephen J Wood, Christos Pantelis

2011-05-01

Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of onset in late adolescence. Late adole..

Neuroanatomical abnormalities in schizophrenia: A multimodal voxelwise meta-analysis and meta-regression analysis

Emre Bora, Alex Fornito, Joaquim Radua, Mark Walterfang, Marc Seal, Stephen J Wood, Murat Yuecel, Dennis Velakoulis, Christos Pantelis

2011-04-01

Despite an increasing number of published voxel based morphometry studies of schizophrenia, there has been no adequate attempt to ..

Structural Trait Markers of Bipolar Disorder: Disruption of White Matter Integrity and Localized Gray Matter Abnormalities in Anterior Fronto-Limbic Regions

Emre Bora, Christos Pantelis

2011-02-15

Commentary on "Should the diagnostic boundaries of schizophrenia be expanded?"

AR Yung, SJ Wood, PD McGorry, C Pantelis

2011-01-01

Disrupted Axonal Fiber Connectivity in Schizophrenia

Andrew Zalesky, Alex Fornito, Marc L Seal, Luca Cocchi, Carl-Fredrik Westin, Edward T Bullmore, Gary F Egan, Christos Pantelis

2011-01-01

BACKGROUND: Schizophrenia is believed to result from abnormal functional integration of neural processes thought to arise from abe..

Neurocognitive markers of psychosis in bipolar disorder: A meta-analytic study

Emre Bora, Murat Yuecel, Christos Pantelis

2010-12-01

BACKGROUND: It has been suggested that patients with psychotic bipolar disorder (BDP+) might have more severe cognitive deficits t..

The Molecular Basis of Lmo2-Induced T-Cell Acute Lymphoblastic Leukemia

David J Curtis, Matthew P McCormack

2010-12-01

T-cell acute lymphoblastic leukemia (T-ALL) is commonly caused by the overexpression of oncogenic transcription factors in develop..

Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study

Katrina L Hannan, Stephen J Wood, Alison R Yung, Dennis Velakoulis, Lisa J Phillips, Bridget Soulsby, Gregor Berger, Patrick D McGorry, Christos Pantelis

2010-06-30

The aim of the present study was to investigate whether volumetric abnormalities of the caudate nuclei predate the onset of psycho..

Voxelwise Meta-Analysis of Gray Matter Abnormalities in Bipolar Disorder

Emre Bora, Alex Fornito, Murat Yucel, Christos Pantelis

2010-06-01

BACKGROUND: We conducted a meta-analysis of gray matter abnormalities in bipolar disorder (BD) using voxel-based morphometry studi..