Dissecting insect gut function to understand insecticide detoxification
Grant number: DP1095295 | Funding period: 2010 - 2013
Massive quantities of chemical insecticides are used daily to control the insect pests that threaten agriculture, human health and the welfare of domestic pets. Insects readily evolve resistance to these chemicals reducing the effectiveness of pest control, increasing the amount of chemical used and increasing costs to consumers. This project examines the way in which insects adapt to the extreme stress imposed on them by chemical insecticides. A thorough understanding of this adaptation process is required before insecticide resistance can be effectively managed or prevented.
Related publications (4)
Evidence for activation of nitenpyram by a mitochondrial cytochrome P450 in Drosophila melanogaster
Thomas WR Harrop, Shane Denecke, Ying Ting Yang, Janice Chan, Phillip J Daborn, Trent Perry, Philip Batterham
BACKGROUND: Nitenpyram is a member of the economically important neonicotinoid class of insecticides. The in vivo metabolism of ni..
Whole-Genome Expression Analysis in the Third Instar Larval Midgut of Drosophila melanogaster
Thomas WR Harrop, Stephen L Pearce, Phillip J Daborn, Philip Batterham
Survival of insects on a substrate containing toxic substances such as plant secondary metabolites or insecticides is dependent on..
Using Drosophila melanogaster to validate metabolism-based insecticide resistance from insect pests
Phillip J Daborn, Christopher Lumb, Thomas WR Harrop, Alex Blasetti, Shivani Pasricha, Shai Morin, Sara N Mitchell, Martin J Donnelly, Pie Mueller, Philip Batterham
Identifying molecular mechanisms of insecticide resistance is important for preserving insecticide efficacy, developing new insect..