Unravelling the sub-nuclear complexity of the brain.
Grant number: DP1094301 | Funding period: 2010 - 2013
Understanding the function of the brain is a major frontier of scientific research. The ability to increase knowledge of brain function is reliant upon the development of novel methods. This application will develop a novel approach for understanding the function of particular nerve cells. One outcome will be demonstration of the applicability of a novel method of benefit to all brain researchers. Another outcome will be increased understanding of one brain region that is known to contribute to the development of cardiovascular disease. It is expected that increased knowledge of brain function will lead to novel theories of brain disease and therapeutic strategies.
Related publications (6)
Functional and neurochemical characterization of angiotensin type 1A receptor-expressing neurons in the nucleus of the solitary tract of the mouse
DA Carter, Y-T Choong, AA Connelly, JK Bassi, NO Hunter, N Thongsepee, IJ Llewellyn-Smith, AY Fong, SJ McDougall, AM Allen
Angiotensin II acts via two main receptors within the central nervous system, with the type 1A receptor (AT1AR) most widely expres..
Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension
Clement Menuet, Sheng Le, Bowen Dempsey, Angela A Connelly, Jessica L Kamar, Nikola Jancovski, Jaspreet K Bassi, Keryn Walters, Annabel E Simms, Andrew Hammond, Angelina Y Fong, Ann K Goodchild, Simon McMullan, Andrew M Allen
The etiology of hypertension, the world's biggest killer, remains poorly understood, with treatments targeting the established sym..
Identification of CNS neurons with polysynaptic connections to both the sympathetic and parasympathetic innervation of the submandibular gland
NS Hettigoda, AY Fong, E Badoer, MJ McKinley, BJ Oldfield, AM Allen
Coordinated modulation of sympathetic and parasympathetic nervous activity is required for physiological regulation of tissue func..
Angiotensin type 1A receptor expression in C1 neurons of the rostral ventrolateral medulla contributes to the development of angiotensin-dependent hypertension
Nikola Jancovski, David A Carter, Angela A Connelly, Elyse Stevens, Jaspreet K Bassi, Clement Menuet, Andrew M Allen
Chronic low-dose systemic infusion of angiotensin II induces hypertension via activation of the angiotensin II type 1A receptor (A..
Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata
Nephtali Marina, Ana PL Abdala, Alla Korsak, Annabel E Simms, Andrew M Allen, Julian FR Paton, Alexander V Gourine
AIMS: Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia a..