Genes, Neuroanatomy & Family Process: Predicting Adolescent Anxiety & Depression
Grant number: DP1092637 | Funding period: 2010 - 2013
Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the paucity of developmentally targeted treatment and prevention strategies. This study will provide unique information regarding the risk processes that are operating during early and late adolescence, and will inform us about how the family environment can act to modulate the impacts of biological vulnerability on risk for mental disorder. This project will contribute to our understanding of who, and what, to target in early intervention and prevention strategies.
Related publications (9)
The long-term associations between parental behaviors, cognitive function and brain activation in adolescence
Orwa Dandash, Nicolas Cherbuin, Orli Schwartz, Nicholas B Allen, Sarah Whittle
Parenting behavior has a vital role in the development of the brain and cognitive abilities of offspring throughout childhood and ..
Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms
Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar, Andrew Zalesky, Nicholas B Allen, Sarah Whittle
BACKGROUND: Childhood maltreatment is associated with lifelong psychiatric sequelae. However, our understanding of neurobiological..
Associations between early life stress and anterior pituitary gland volume development - A novel index of long-term hypothalamic-pituitary-adrenal axis functioning
Carmela Diaz-Arteche, Julian G Simmons, Despina E Ganella, Orli Schwartz, Jee Hyun Kim, Paige Farrow, Sarah Whittle
Previous research has established associations between early life stress (ELS) and altered pituitary gland volume (PGV) growth dur..
Longitudinal Trajectories of Depression Symptoms in Adolescence: Psychosocial Risk Factors and Outcomes
Rachel ER Ellis, Marc L Seal, Julian G Simmons, Sarah Whittle, Orli S Schwartz, Michelle L Byrne, Nicholas B Allen
Variations in symptom trajectories within a population may represent distinct groups with different etiologies and outcomes. This ..
Brain connectivity networks and longitudinal trajectories of depression symptoms in adolescence
Rachel Ellis, Marc L Seal, Christopher Adamson, Richard Beare, Julian G Simmons, Sarah Whittle, Nicholas B Allen
High levels of depression during adolescence may contribute to the risk for future depression later in life. This study examined t..
Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence
Sarah Whittle, Julian G Simmons, Sylke Hendriksma, Nandita Vijayakumar, Michelle L Byrne, Meg Dennison, Nicholas B Allen
INTRODUCTION: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocamp..
Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study
S Oostermeijer, S Whittle, C Suo, NB Allen, JG Simmons, N Vijayakumar, PM van de Ven, LMC Jansen, M Yucel, A Popma
Multiple cross-sectional imaging studies have identified structural abnormalities in prefrontal, temporal and limbic regions relat..
Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes
Meg Dennison, Sarah Whittle, Murat Yuecel, Nandita Vijayakumar, Alexandria Kline, Julian Simmons, Nicholas B Allen
Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these ..