Mother and baby communication during early pregnancy, the key to establishing a healthy pregnancy
Grant number: 628927 | Funding period: 2010 - 2015
Related publications (20)
Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction
Natalie J Hannan, Sally Beard, Natalie K Binder, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino, Qi Chen, Laura Tuohey, Manarangi De Silva, Stephen Tong
INTRODUCTION: Preeclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of perinatal morbidity and mortali..
Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation
Natalie K Binder, Jemma Evans, Lois A Salamonsen, David K Gardner, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced..
Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity
Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Louie Ye, Natalie Binder, Ping Cannon, Laura Tuohey, Terrance G Johns, Alexis Shub, Stephen Tong
In preeclampsia, the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT-1) is released from placenta into the maternal..
Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion
Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Sally Beard, Roxanne Hastie, Natalie K Binder, Cathy Cluver, Laura Tuohey, Clare Whitehead, Fiona Brownfoot, Manarangi De Silva, Natalie J Hannan
Elevated placental release of the antiangiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG),..
Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia
Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Natalie K Binder, Susan P Walker, Ping Cannon, Roxanne Hastie, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino
UNLABELLED: Preeclampsia is a major pregnancy complication where excess placental release of soluble fms-like tyrosine kinase-1 (s..
Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation
Owen Stock, Lavinia Gordon, Jada Kapoor, Susan P Walker, Clare Whitehead, Tu'uhevaha J Kaitu'u-Lino, Gabrielle Pell, Natalie J Hannan, Stephen Tong
BACKGROUND: Preterm prelabor rupture of the fetal membranes (PPROM) is a significant contributor to the morbidity and mortality of..
Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development
Jordanna S Master, George A Thouas, Alexandra J Harvey, John R Sheedy, Natalie J Hannan, David K Gardner, Mary E Wlodek
Low birth weight is associated with an increased risk for adult disease development with recent studies highlighting transmission ..
Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model
Natalie K Binder, John R Sheedy, Natalie J Hannan, David K Gardner
The rate of obesity among men of reproductive age has tripled in the last three decades. Previously, we demonstrated that paternal..
Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner
Natalie K Binder, Sally A Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan, David K Gardner
Fetal growth restriction (FGR) is a major obstetric complication stemming from poor placental development. We have previously demo..
Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction Potential Therapeutic for Preeclampsia
Kenji Onda, Stephen Tong, Anzu Nakahara, Mei Kondo, Hideaki Monchusho, Toshihiko Hirano, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Natalie Binder, Laura Tuohey, Fiona Brownfoot, Natalie J Hannan
Preeclampsia is a severe complication of pregnancy, characterized by hypertension, oxidative stress, and severe endothelial dysfun..
Placental SEMA3B expression is not altered in severe early onset preeclampsia
TJ Kaitu'u-Lino, R Hastie, P Cannon, NK Binder, S Lee, O Stock, NJ Hannan, S Tong
Recent evidence suggests that Semaphorin 3B (SEMA3B) is upregulated in severe preeclampsia, and a major driver of cytotrophoblast ..
Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR
TJ Kaitu'u-Lino, R Hastie, P Cannon, S Lee, O Stock, NJ Hannan, R Hiscock, S Tong
Measuring mRNA expression is fundamental to placental research. Ideally, mRNA transcript numbers are directly quantified. However,..
Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin
Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Sally Beard, Roxanne Hastie, Laura Tuohey, Fiona Brownfoot, Kenji Onda, Natalie J Hannan
OBJECTIVES: Soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) are the most studied molecules in preeclampsia..
Endometrial signals improve embryo outcome: functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice
NK Binder, J Evans, DK Gardner, LA Salamonsen, NJ Hannan
STUDY QUESTION: Does vascular endothelial growth factor (VEGF) have important roles during early embryo development and implantati..
A Bioplex Analysis of Cytokines and Chemokines in First Trimester Maternal Plasma to Screen for Predictors of Miscarriage
Natalie J Hannan, Katerina Bambang, Tu'uhevaha J Kaitu'u-Lino, Justin C Konje, Stephen Tong
BACKGROUND: We have previously shown in two independent cohorts that circulating first trimester Macrophage Inhibitory Cytokine-1 ..
Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery
Lois A Salamonsen, Tracey Edgell, Luk JF Rombauts, Andrew N Stephens, David M Robertson, Adam Rainczuk, Guiying Nie, Natalie J Hannan
Failure of the endometrium to achieve receptivity results in infertility, and it is also a rate-limiting step in in vitro fertiliz..
Defective Soil for a Fertile Seed? Altered Endometrial Development Is Detrimental to Pregnancy Success
Jemma Evans, Natalie J Hannan, Cassandra Hincks, Luk JF Rombauts, Lois A Salamonsen
BACKGROUND: Synchronous development of the endometrium (to achieve a receptive state) and of the embryo is essential for successfu..
Paternal Diet-Induced Obesity Retards Early Mouse Embryo Development, Mitochondrial Activity and Pregnancy Health
Natalie K Binder, Natalie J Hannan, David K Gardner
Worldwide, 48% of adult males are overweight or obese. An association between infertility and excessive body weight is now accepte..