Kava in the Treatment of Chronic Anxiety

S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: Efficacy and effects of histamine and carnitine as moderators of response

J Sarris, G I. Papakostas, O Vitolo, M Fava, D Mischoulon

2014-08-01

Objective To assess the antidepressant efficacy of S-adenosyl methionine (SAMe), a naturally occurring methyl donor, versus the se..

Naturopathic medicine for treating self-reported depression and anxiety: An observational pilot study of naturalistic practice

J Sarris, S Gadsden, I Schweitzer

2014-05-01

Overview: We conducted the first observational study of a case series of naturopathic consultations of adults who presented with s..

Integrative mental healthcare White Paper: Establishing a new paradigm through research, education, and clinical guidelines

J Sarris, R Glick, R Hoenders, J Duffy, J Lake

2014-01-01

Mental illness accounts for about one-third of adult disability globally, reflecting marked societal and personal suffering, and e..

The International Network of Integrative Mental Health (INIMH)

J Sarris, R Glick, C Helgason, C Veizer, J Lake

2014-01-01

To address the current challenges facing mental healthcare, the International Network of Integrative Mental Health (INIMH: www.INI..

Kava for the treatment of generalized anxiety disorder RCT: Analysis of adverse reactions, liver function, addiction, and sexual effects

J Sarris, C Stough, R Teschke, ZT Wahid, CA Bousman, G Murray, KM Savage, P Mouatt, C Ng, I Schweitzer

2013-11-01

Presently, little is known about a number issues concerning kava (Piper methysticum), including (i) whether kava has any withdrawa..

Kava in the treatment of generalized anxiety disorder: A double-blind, randomized, placebo-controlled study

J Sarris, C Stough, CA Bousman, ZT Wahid, G Murray, R Teschke, KM Savage, A Dowell, C Ng, I Schweitzer

2013-10-01

Kava (Piper methysticum) is a plant-based medicine, which has been previously shown to reduce anxiety. To date, however, no placeb..

Pharmacogenetic polymorphisms and response to escitalopram and venlafaxine over 8 weeks in major depression

C Ng, J Sarris, A Singh, C Bousman, K Byron, LH Peh, DJ Smith, CH Tan, I Schweitzer

2013-09-01

Objective The objective of this study is to investigate the influence of the 5-HTTLPR (serotonin transporter-linked promoter regio..

Plant-based medicines for anxiety disorders, part 1: A review of preclinical studies

J Sarris, E McIntyre, DA Camfield

2013-03-01

Research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the tr..

St. John's Wort for the Treatment of Psychiatric Disorders

J Sarris

2013-03-01

St. John's wort (Hypericum perforatum) has been extensively studied and reviewed for its use in depression; however, there is less..

Aripiprazole as augmentation therapy in bipolar patients with current minor or subsyndromal mood symptoms

I Schweitzer, J Sarris, V Tuckwell, K Maguire, D Smith, C Ng

2013-01-01

Background: This study aims to evaluate the effectiveness of aripiprazole augmentation of maintenance treatment for bipolar disord..

Does a Medicinal Dose of Kava Impair Driving? A Randomized, Placebo-Controlled, Double-Blind Study

J Sarris, E LaPorte, A Scholey, R King, A Pipingas, I Schweitzer, C Stough

2013-01-01

Overview: Increasing concerns over the potentially impairing effects of prescriptive sedative drugs such as benzodiazepines on dri..

Lifestyle management of unipolar depression

M Berk, J Sarris, CE Coulson, FN Jacka

2013-01-01

Objective: To be used in conjunction with 'Pharmacological management of unipolar depression' [Malhi et al. Acta Psychiatr Scand 2..

Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence

J Sarris, E McIntyre, DA Camfield

2013-01-01

Research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the tr..

Participant experiences from chronic administration of a multivitamin versus placebo on subjective health and wellbeing: A double-blind qualitative analysis of a randomised controlled trial

J Sarris, KHM Cox, DA Camfield, A Scholey, C Stough, E Fogg, M Kras, DJ White, A Sali, A Pipingas

2012-12-18

Background: While many randomised controlled trials have been conducted on multivitamins, to our knowledge no qualitative research..

Complementary medicine, exercise, meditation, diet, and lifestyle modification for anxiety disorders: A review of current evidence

J Sarris, S Moylan, DA Camfield, MP Pase, D Mischoulon, M Berk, FN Jacka, I Schweitzer

2012-09-18

Use of complementary medicines and therapies (CAM) and modification of lifestyle factors such as physical activity, exercise, and ..

The cognitive-enhancing effects of bacopa monnieri: A systematic review of randomized, controlled human clinical trials

MP Pase, J Kean, J Sarris, C Neale, AB Scholey, C Stough

2012-07-01

Objectives: Traditional knowledge suggests that Bacopa monnieri enhances cognitive performance. Such traditional beliefs have now ..

St Johns Wort (Hypericum perforatum) versus sertraline and placebo in major depressive disorder: Continuation data from a 26-week RCT

J Sarris, M Fava, I Schweitzer, D Mischoulon

2012-05-17

Introduction: Hypericum perforatum (St Johns wort: SJW) has been extensively studied as an antidepressant in short-term trials, ho..

Complementary medicine, self-help, and lifestyle interventions for Obsessive Compulsive Disorder (OCD) and the OCD spectrum: A systematic review

J Sarris, D Camfield, M Berk

2012-05-01

Background: In Obsessive Compulsive Disorder (OCD) current standard pharmacotherapies may be of limited efficacy. Non-conventional..

The acute effects of kava and oxazepam on anxiety, mood, neurocognition; And genetic correlates: A randomized, placebo-controlled, double-blind study

J Sarris, A Scholey, I Schweitzer, C Bousman, E LaPorte, C Ng, G Murray, C Stough

2012-05-01

Rationale Kava (Piper methysticum) is a psychotropic plant medicine with history of cultural and medicinal use. We conducted a stu..

Omic genetic technologies for herbal medicines in psychiatry

J Sarris, CH Ng, I Schweitzer

2012-04-01

The field of genetics, which includes the use of 'omic' technologies, is an evolving area of science that has emerging application..

Integrative mental health (IMH): Paradigm, research, and clinical practice

J Lake, C Helgason, J Sarris

2012-01-01

This paper provides an overview of the rapidly evolving paradigm of "Integrative Mental Health (IMH)." The paradigm of contemporar..

Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence

J Sarris, A Panossian, I Schweitzer, C Stough, A Scholey

2011-12-01

Research in the area of herbal psychopharmacology has increased markedly over the past decades. To date however, a comprehensive r..

Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials

MP Pase, NA Grima, J Sarris

2011-10-14

Fish oils, rich in long-chain n-3 PUFA, are known to reduce various risk factors for CVD. However, conclusive evidence regarding t..

Bipolar disorder and complementary medicine: Current evidence, safety issues, and clinical considerations

J Sarris, J Lake, R Hoenders

2011-10-01

Background: Bipolar disorder (BD) is a debilitating syndrome that is often undiagnosed and undertreated. Population surveys show t..

A randomized, controlled trial of meditation for work stress, anxiety and depressed mood in full-time workers

R Manocha, D Black, J Sarris, C Stough

2011-09-19

Objective: To assess the effect of meditation on work stress, anxiety and mood in full-time workers. Methods. 178 adult workers pa..

Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: A systematic review of clinical trials

J Sarris, D Mischoulon, I Schweitzer

2011-08-01

Objective: Studies using augmentation of pharmacotherapies with nutraceuticals in bipolar disorder (BD) have been conducted and pr..

Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): A systematic review of the evidence

J Sarris, J Kean, I Schweitzer, J Lake

2011-08-01

Overview: Complementary and Alternative Medicines (CAMs) are frequently given to children and adolescents for reputed benefits in ..

Clinical depression: An evidence-based integrative complementary medicine treatment model

J Sarris

2011-07-01

Background • Clinical depression has a major impact on individuals and society, often presenting the clinician with a significant ..

Nutraceuticals in the treatment of Obsessive Compulsive Disorder (OCD): A review of mechanistic and clinical evidence

DA Camfield, J Sarris, M Berk

2011-06-01

Obsessive-Compulsive Disorder (OCD) is a debilitating mental illness which has a significant impact on quality of life. First-line..

A systematic review of insomnia and complementary medicine

J Sarris, GJ Byrne

2011-04-01

In concert with growing public interest in complementary and alternative medicine (CAM), these therapies and products have been in..

Neurocognitive effects of kava (Piper methysticum): A systematic review

E Laporte, J Sarris, C Stough, A Scholey

2011-03-01

Rationale Kava (Piper methysticum) elicits dose-dependent psychotropic effects and thus may potentially deleteriously affect cogni..

The effects of dietary and nutrient interventions on arterial stiffness: A systematic review

MP Pase, NA Grima, J Sarris

2011-02-01

Background: Although dietary and nutrient interventions have been extensively studied as a means of improving arterial stiffness, ..

Kava: A comprehensive review of efficacy, safety, and psychopharmacology

J Sarris, E Laporte, I Schweitzer

2011-01-01

Overview: Kava (Piper methysticum) is a South Pacific psychotropic plant medicine that has anxiolytic activity. This effect is ach..