CENTRE FOR FREE RADICAL CHEMISTRY AND BIOTECHNOLOGY

Photophysical insights and guidelines for blue "turn-on" fluorescent probes for the direct detection of nitric oxide (NO center dot) in biological systems

Mina Barzegar Amiri Olia, Amber N Hancock, Carl H Schiesser, Lars Goerigk, Uta Wille

2019-02-01

Synthesis and photophysical properties of a family of five blue fluorescent “turn-on” probes for the direct detection of nitric ox..

Amide Neighbouring-Group Effects in Peptides: Phenylalanine as Relay Amino Acid in Long-Distance Electron Transfer

Joses G Nathanael, Luke F Gamon, Meike Cordes, Paul R Rablen, Thomas Bally, Katharina M Fromm, Bernd Giese, Uta Wille

2018-05-04

In nature, proteins serve as media for long-distance electron transfer (ET) to carry out redox reactions in distant compartments. ..

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Elton L Borges, Marta T Ignasiak, Yuliia Velichenko, Gelson Perin, Craig A Hutton, Michael J Davies, Carl H Schiesser

2018-03-25

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic ..

Watson-Crick Base Pair Radical Cation as a Model for Oxidative Damage in DNA

Linda Feketeova, Bun Chan, George N Khairaah, Vincent Steinmetz, Philippe Maitre, Leo Radom, Richard AJ O'Hair

2017-07-06

The deleterious cellular effects of ionizing radiation are well-known, but the mechanisms causing DNA damage are poorly understood..

Gas-Phase Intercluster Thiyl-Radical Induced C-H Bond Homolysis Selectively Forms Sugar C2-Radical Cations of Methyl D-Glucopyranoside: Isotopic Labeling Studies and Cleavage Reactions

Sandra Osburn, Gaetano Speciale, Spencer J Williams, Richard AJ O'Hair

2017-07-01

A suite of isotopologues of methyl D-glucopyranosides is used in conjunction with multistage mass spectrometry experiments to dete..

Oxidative Damage of Biomolecules by the Environmental Pollutants NO2 center dot and NO3 center dot

Luke F Gamon, Uta Wille

2016-10-01

Air pollution is responsible for the premature death of about 7 million people every year. Ozone (O3) and nitrogen dioxide (NO2•) ..

Two Spin-State Reactivity in the Activation and Cleavage of CO2 by [ReO2](-)

Valentino Canale, Robert Robinson, Athanasios Zavras, George N Khairallah, Nicola d'Alessandro, Brian F Yates, Richard AJ O'Hair

2016-05-19

The rhenium dioxide anion [ReO2](-) reacts with carbon dioxide in a linear ion trap mass spectrometer to produce [ReO3](-) corresp..

Formation and stability of gas-phase o-benzoquinone from oxidation of ortho-hydroxyphenyl: a combined neutral and distonic radical study

Matthew B Prendergast, Benjamin B Kirk, John D Savee, David L Osborn, Craig A Taatjes, Kye-Simeon Masters, Stephen J Blanksby, Gabriel da Silva, Adam J Trevitt

2016-02-14

Gas-phase product detection studies of o-hydroxyphenyl radical and O2 are reported at 373, 500, and 600 K, at 4 Torr (533.3 Pa), u..

Structure of olefin-imidacloprid and gas-phase fragmentation chemistry of its protonated form

Roberto Fusetto, Jonathan M White, Craig A Hutton, Richard AJ O'Hair

2016-01-01

One of the major insect metabolites of the widely used neonicotinoid insecticide imidacloprid, 1 (1-[(6-chloro-3-pyridinyl)methyl]..

Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance

Corin Storkey, David I Pattison, Marta T Ignasiak, Carl H Schiesser, Michael J Davies

2015-12-01

Peroxynitrite (the physiological mixture of ONOOH and its anion, ONOO(-)) is a powerful biologically-relevant oxidant capable of o..

What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)?

Michael G Leeming, Luke F Gamon, Uta Wille, William A Donald, Richard AJ O'Hair

2015-11-01

Acetaminophen (paracetamol, APAP) is a safe and widely used analgesic medication when taken at therapeutic doses. However, APAP ca..

Radical Formation in the Gas-Phase Ozonolysis of Deprotonated Cysteine

George N Khairallah, Alan T Maccarone, Huong T Pham, Timothy M Benton, Tony Ly, Gabriel da Silva, Stephen J Blanksby, Richard AJ O'Hair

2015-10-26

Although the deleterious effects of ozone on the human respiratory system are well-known, many of the precise chemical mechanisms ..

Radical Formation in the Gas-Phase Ozonolysis of Deprotonated Cysteine

George N Khairallah, Alan T Maccarone, Huong T Pham, Timothy M Benton, Tony Ly, Gabriel da Silva, Stephen J Blanksby, Richard AJ O'Hair

2015-10-26

Ultraviolet photodissociation action spectroscopy of the N-pyridinium cation

Christopher S Hansen, Stephen J Blanksby, Nahid Chalyavi, Evan J Bieske, Jeffrey R Reimers, Adam J Trevitt

2015-01-07

The S1←S0 electronic transition of the N-pyridinium ion (C5H5NH(+)) is investigated using ultraviolet photodissociation (PD) spect..

Gas-phase structure and reactivity of the keto tautomer of the deoxyguanosine radical cation

Linda Feketeova, Bun Chan, George N Khairallah, Vincent Steinmetz, Philippe Maitre, Leo Radom, Richard AJ O'Hair

2015-01-01

Guanine radical cations are formed upon oxidation of DNA. Deoxyguanosine (dG) is used as a model, and the gas-phase infrared (IR) ..

The role of peroxyl radicals in polyester degradation - a mass spectrometric product and kinetic study using the distonic radical ion approach

BD Gervasoni, GN Khairallah, RAJ O'Hair, U Wille

2015-01-01

Mass spectrometric techniques were used to obtain detailed insight into the reactions of peroxyl radicals with model systems of (d..

Direct detection of brominated flame retardants from plastic e-waste using liquid extraction surface analysis mass spectrometry

Martin RL Paine, Ian D Rae, Stephen J Blanksby

2014-06-15

RATIONALE: The worldwide generation of plastic electronic waste (e-waste) is reaching epic proportions. The presence of toxic brom..

Mass Spectrometric and Computational Studies on the Reaction of Aromatic Peroxyl Radicals with Phenylacetylene Using the Distonic Radical Ion Approach

George N Khairallah, Richard AJ O'Hair, Uta Wille

2014-05-08

Product and mechanistic studies were performed for the reaction of aromatic distonic peroxyl radical cations 4-PyrOO(•+) and 3-Pyr..

Unimolecular reaction chemistry of a charge-tagged beta-hydroxyperoxyl radical

Sui So, Benjamin B Kirk, Adam J Trevitt, Uta Wille, Stephen J Blanksby, Gabriel da Silva

2014-01-01

β-Hydroxyperoxyl radicals are formed during atmospheric oxidation of unsaturated volatile organic compounds such as isoprene. They..

UV Photodissociation Action Spectroscopy of Haloanilinium Ions in a Linear Quadrupole Ion Trap Mass Spectrometer

Christopher S Hansen, Benjamin B Kirk, Stephen J Blanksby, Richard AJ O'Hair, Adam J Trevitt

2013-06-01

UV-vis photodissociation action spectroscopy is becoming increasingly prevalent because of advances in, and commercial availabilit..

Hydroxyl radical formation in the gas phase oxidation of distonic 2-methylphenyl radical cations

Matthew B Prendergast, Phillip A Cooper, Benjamin B Kirk, Gabriel da Silva, Stephen J Blanksby, Adam J Trevitt

2013-01-01

The reactions of distonic 4-(N,N,N-trimethylammonium)-2-methylphenyl and 5-(N,N,N-trimethylammonium)-2-methylphenyl radical cation..

Concerted HO2 Elimination from alpha-Aminoalkylperoxyl Free Radicals: Experimental and Theoretical Evidence from the Gas-Phase NH2 center dot CHCO2- O-2 Reaction

Gabriel da Silva, Benjamin B Kirk, Celli Lloyd, Adam J Trevitt, Stephen J Blanksby

2012-04-05

We have investigated the gas-phase reaction of the α-aminoacetate (glycyl) radical anion (NH2(•)CHCO2(-)) with O2 using ion trap m..

Gas-phase reactions of aryl radicals with 2-butyne: an experimental and theoretical investigation employing the N-methyl-pyridinium-4-yl radical cation

Adrian KY Lam, Cong Li, George Khairallah, Benjamin B Kirk, Stephen J Blanksby, Adam J Trevitt, Uta Wille, Richard AJ O'Hair, Gabriel da Silva

2012-01-01

Aromatic radicals form in a variety of reacting gas-phase systems, where their molecular weight growth reactions with unsaturated ..

Peroxidase catalysed cross-Linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima

Kelly Mai, Nicholas C Smith, Zhi-Ping Feng, Marilyn Katrib, Jan Slapeta, Iveta Slapetova, Michael G Wallach, Catherine Luxford, Michael J Davies, Xuecheng Zhang, Raymond S Norton, Sabina I Belli

2011-09-01

Apicomplexan parasites such as Eimeria maxima possess a resilient oocyst wall that protects them upon excretion in host faeces and..

Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3

Alexander V Peskin, Andrew G Cox, Peter Nagy, Philip E Morgan, Mark B Hampton, Michael J Davies, Christine C Winterbourn

2010-12-01

Prxs (peroxiredoxins) are a ubiquitous family of cysteine-dependent peroxidases that react rapidly with H2O2 and alkyl hydroperoxi..