Targeting Protein Synthesis In The Apicoplast And Cytoplasm Of Plasmodium

Abstract

New antimalarial drugs are desperately needed. Protein synthesis in Plasmodium falciparum is a validated target for existing drugs and is a promising target for new drugs. This project brings together malaria biologists with chemists and computer scientists to explore this promising field. We will apply modern methods of drug target characterisation to find the most promising enzyme targets involved in protein synthesis and to identify inhibitors as leads for developing antimalarial therapies. Australian researchers involved in this project will provide expertise in bioinformatic prioritisation of Plasmodium drug targets from the aminoacyl tRNA synthetase family of enzymes. We will use struc..

Related publications (1)

A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNA(Cys)

James S Pham, Reiko Sakaguchi, Lee M Yeoh, Nilushi S De Silva, Geoffrey I McFadden, Ya-Ming Hou, Stuart A Ralph

2014-03-15