PROGRESSIVE APHASIA AND AMYLOID DEPOSITION: A MULTIDISCIPLINARY APPROACH TO IMPROVING DEMENTIA DIAGNOSIS

Grant number: 630489 | Funding period: 2010 - 2012

Completed

Abstract

We aim to understand the role of amyloid deposition in the genesis of symptoms in Alzheimer's disease. Patients presenting with progressive deterioration of language (aphasia) some of whom are known to have Alzheimer's disease will be studied using brain imaging techniques, including a PET method (PiB) that labels amyloid in vivo, and to compare imaging changes with a range of language assessments. This will improve the early diagnosis and management of patients with progressive aphasia.

Related publications (5)

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Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease

Sanka Amadoru, Vincent Dore, Catriona A McLean, Fairlie Hinton, Claire E Shepherd, Glenda M Halliday, Cristian E Leyton, Paul A Yates, John R Hodges, Colin L Masters, Victor L Villemagne, Christopher C Rowe

2020-03-04

BACKGROUND: The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centi..

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Divergent Network Patterns of Amyloid-β Deposition in Logopenic and Amnestic Alzheimer's Disease Presentations.

Cristian E Leyton, Ben Cassidy, Victor L Villemagne, Gareth Jones, John B Kwok, Christopher C Rowe, Kirrie J Ballard, Olivier Piguet, John R Hodges

2016-01-01

BACKGROUND: Despite divergent clinical features, language and amnestic presentations of Alzheimer's disease (AD) appear to show co..

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Is the logopenic-variant of primary progressive aphasia a unitary disorder?

Cristian E Leyton, John R Hodges, Catriona A McLean, Jillian J Kril, Olivier Piguet, Kirrie J Ballard

2015-06-01

Logopenic progressive aphasia is one of the clinical presentations of primary progressive aphasia and formally defined by the co-o..

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Logopenic and Nonfluent Variants of Primary Progressive Aphasia Are Differentiated by Acoustic Measures of Speech Production

Kirrie J Ballard, Sharon Savage, Cristian E Leyton, Adam P Vogel, Michael Hornberger, John R Hodges

2014-02-28

Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet re..

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Subtypes of progressive aphasia: application of the international consensus criteria and validation using beta-amyloid imaging

Cristian E Leyton, Victor L Villemagne, Sharon Savage, Kerryn E Pike, Kirrie J Ballard, Olivier Piguet, James R Burrell, Christopher C Rowe, John R Hodges

2011-10-01

Primary progressive aphasia comprises a heterogeneous group of neurodegenerative conditions with diverse clinical profiles and und..

University of Melbourne Researchers