THE ASSOCIATIONS BETWEEN COGNITIVE DECLINE AND GENETIC POLYMORPHISMS, HORMONES AND CARDIOVQSCULAR RISK FACTORS IN WOMEN
Grant number: 547600 | Funding period: 2011 - 2014
Dementia, a major cause of morbidity and mortality in ageing women, has been linked to hormonal changes and genes. If factors associated with impaired cognition and early Alzheimer's disease could be identified then early interventions could be offered to those at risk. In this study we determine the genetic, medical and lifestyle factors which may be associated with cognitive decline and early Alzheimer's disease in women from pre-menopause into their post-menopausal years.
Related publications (18)
Influence of Physical Activity Levels and Functional Capacity on Brain beta-Amyloid Deposition in Older Women
Raquel Pedrero-Chamizo, Cassandra Szoeke, Lorraine Dennerstein, Stephen Campbell
Physical activity (PA) and Alzheimer's disease are associated. However, how PA influences the cerebral β-amyloid (Aβ) burden remai..
Mid-life predictors of late-life depressive symptoms; determining risk factors spanning two decades in the Women's Heathy Ageing Project.
Katherine E Campbell, Alexandra Gorelik, Cassandra E Szoeke, Lorraine Dennerstein
Background: Data available from longitudinal studies of adequate duration to explore midlife risk factors for late life higher dep..
Depression related cerebral pathology and its relationship with cognitive functioning: A systematic review
Alec Jamieson, Alicia M Goodwill, Mario Termine, Stephen Campbell, Cassandra Szoeke
BACKGROUND: Depression's relationship with cerebral abnormalities and cognitive decline is temporally dynamic. Despite clear clini..
Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
Catherine Owens Johnson, Nguyen Minh, Gregory A Roth, Emma Nichols, Tahiya Alam, Degu Abate, Foad Abd-Allah, Ahmed Abdelalim, Haftom Niguse Abraha, Niveen Me Abu-Rmeileh, Oladimeji M Adebayo, Abiodun Moshood Adeoye, Gina Agarwal, Sutapa Agrawal, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Fares Alahdab, Raghib Ali, Nelson Alvis-Guzman
BACKGROUND: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke ca..
Robust Norms for Neuropsychological Tests of Verbal Episodic Memory in Australian Women
Alicia M Goodwill, Stephen Campbell, Victor W Henderson, Alexandra Gorelik, Lorraine Dennerstein, Michael McClung, Cassandra Szoeke
OBJECTIVE: Robust norms for neuropsychological tests may offer superior clinical utility to conventional norms, in their ability t..
A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study
Kay L Cox, Elizabeth Cyarto, Kathryn A Ellis, David Ames, Patricia Desmond, Pramit Phal, Matthew J Sharman, Cassandra Szoeke, Christopher C Rowe, Colin L Masters, Emily You, Sally Burrows, Michelle MY Lai, Nicola T Lautenschlager
BACKGROUND: Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcom..
Self-reported confusion is related to global and regional beta-amyloid: data from the Women's healthy ageing project
Georgia E McCluskey, Paul Yates, Victor L Villemagne, Christopher Rowe, Cassandra EI Szoeke
Disease-modifying treatments for Alzheimer's disease (AD) may require implementation during early stages of β-amyloid accumulation..
Dietary patterns and β-amyloid deposition in aging Australian women.
Edward Hill, Peter Clifton, Alicia M Goodwill, Lorraine Dennerstein, Stephen Campbell, Cassandra Szoeke
Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such ..
Vitamin D status is associated with executive function a decade later: Data from the Women's Healthy Ageing Project
Alicia M Goodwill, Stephen Campbell, Steven Simpson, Maria Bisignano, Cherie Chiang, Lorraine Dennerstein, Cassandra Szoeke
OBJECTIVES: Vitamin D deficiency has been associated with cognitive decline and dementia in older adults. However, there is a pauc..
Unhealthy habits persist: The ongoing presence of modifiable risk factors for disease in women
Cassandra Szoeke, Christa Dang, Philippe Lehert, Martha Hickey, Meg E Morris, Lorraine Dennerstein, Stephen Campbell
OBJECTIVES: Vascular disease remains a leading cause of death. There are several vascular risk factors identified that can mitigat..
Predictive Factors for Verbal Memory Performance Over Decades of Aging: Data from the Women's Healthy Ageing Project
Cassandra Szoeke, Philippe Lehert, Victor W Henderson, Lorraine Dennerstein, Patricia Desmond, Stephen Campbell
BACKGROUND: Abnormalities in brain structure and function can occur several decades prior to the onset of cognitive decline. It is..
Cohort profile: Women's Healthy Ageing Project (WHAP) - a longitudinal prospective study of Australian women since 1990.
Cassandra Szoeke, Melissa Coulson, Stephen Campbell, Lorraine Dennerstein, null WHAP Investigators
Background: The cohort was commenced to examine women's health from midlife (45-55 years) before the menopausal transition and int..
Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women
Karren HM Chen, Victor W Henderson, Renerus J Stolwyk, Lorraine Dennerstein, Cassandra Szoeke
BACKGROUND: previous studies raised the possibility that adverse health effects associated with elevated blood pressure (BP) begin..
The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia
Cassandra EI Szoeke, Joanne S Robertson, Christopher C Rowe, Paul Yates, Katherine Campbell, Colin L Masters, David Ames, Lorraine Dennerstein, Patricia Desmond
Alzheimer's disease neuropathology (amyloid, tauopathies) and brain atrophy are present decades prior to manifestation of clinical..