Role of HIV-specific ADCC Activity in Progression of HIV-1 in Humans

Grant number: 1R21AI081541-01A2 | Funding period: 2010 - 2012

Completed

Abstract

DESCRIPTION (provided by applicant): A vaccine for HIV is a global health priority. Efforts to develop a successful HIV vaccine using standard immune responses have so far failed. Lateral thinking is required to explore novel phenomena in HIV-specific immunity. The cytotoxic capacity of natural killer (NK) cells provides one such opportunity to open up a new horizon that could eventually be utilised in rational vaccine design. Antibody dependent cell mediated cytotoxicity (ADCC) allows for antigen-specific targeting of NK cell activity. Previous studies of the role of ADCC activity in HIV infection have been hampered by difficulties identifying and mapping these responses. We developed a nov..

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Related publications (10)

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University of Melbourne Researchers