NANOENGINEERED POLYMERIC MATERIALS FOR ENVIRONMENTAL AND BIOLOGICAL APPLICATIONS

Biocompatible Porous Polyester-Ether Hydrogel Scaffolds with Cross-Linker Mediated Biodegradation and Mechanical Properties for Tissue Augmentation

Berkay Ozcelik, Jason Palmer, Katharina Ladewig, Paula Facal Marina, Geoffrey W Stevens, Keren Abberton, Wayne A Morrison, Anton Blencowe, Greg G Qiao

2018-02-01

Porous polyester-ether hydrogel scaffolds (PEHs) were fabricated using acid chloride/alcohol chemistry and a salt templating appro..

Tuning the Properties of Polymer Capsules for Cellular Interactions

Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso

2017-07-01

Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..

Biofunctional metal-phenolic films from dietary flavonoids

Nadja Bertleff-Zieschang, Md Arifur Rahim, Yi Ju, Julia A Braunger, Tomoya Suma, Yunlu Dai, Shuaijun Pan, Francesca Cavalieri, Frank Caruso

2017-01-18

We assembled dietary, bioactive flavonoids into a metal coordinated network to form thin, surface-bound films and hollow capsules,..

Patterned Poly(dopamine) Films for Enhanced Cell Adhesion

Xi Chen, Christina Cortez-Jugo, Gwan H Choi, Mattias Bjornmalm, Yunlu Dai, Pil J Yoo, Frank Caruso

2017-01-01

Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In ..

CO2 separation using surface-functionalized SiO2 nanoparticles incorporated ultra-thin film composite mixed matrix membranes for post-combustion carbon capture

Jinguk Kim, Qiang Fu, Ke Xie, Joel MP Scofield, Sandra E Kentish, Greg G Qiao

2016-10-01

CO2 separation across polyethylene glycol (PEG)-based ultra-thin film composite mixed matrix membranes (UTFC-MMMs) containing surf..

Void Engineering in Metal-Organic Frameworks via Synergistic Etching and Surface Functionalization

Ming Hu, Yi Ju, Kang Liang, Tomoya Suma, Jiwei Cui, Frank Caruso

2016-08-23

The rational design and engineering of metal–organic framework (MOF) crystals with hollow features has been used for various appli..

Blends of Fluorinated Additives with Highly Selective Thin-Film Composite Membranes to Increase CO2 Permeability for CO2/N-2 Gas Separation Applications

Joel MP Scofield, Paul A Gurr, Jinguk Kim, Qiang Fu, Sandra E Kentish, Greg G Qiao

2016-08-03

A highly permeable poly(ethylene glycol-b-pentafluoropropyl acrylate) diblock copolymer additive is blended with the highly select..

Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells

Yi Ju, Jiwei Cui, Huanli Sun, Markus Mullner, Yunlu Dai, Junling Guo, Nadja Bertleff-Zieschang, Tomoya Suma, Joseph J Richardson, Frank Caruso

2016-06-01

We engineered metal-phenolic capsules with both high targeting and low nonspecific cell binding properties. The capsules were prep..

Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles

Shereen Tan, Jiwei Cui, Qiang Fu, Eunhyung Nam, Katharina Ladewig, Jing M Ren, Edgar HH Wong, Frank Caruso, Anton Blencowe, Greg G Qiao

2016-03-09

Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. Th..

Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages

Xi Chen, Yan Yan, Markus Muellner, Yuan Ping, Jiwei Cui, Kristian Kempe, Christina Cortez-Jugo, Frank Caruso

2016-03-01

Particles with tailored geometries have received significant attention due to their specific interactions with biological systems...

Development of Novel Fluorinated Additives for High Performance CO2 Separation Thin-film Composite Membranes

JMP Scofield, P Gurr, J Kim, Q Fu, null Kentish, G QIao

2016-02-01

A series of poly(ethylene glycol)-block-poly(pentafluoropropyl acrylate) diblock copolymers were synthesized by Reversible Additio..

Analysing intracellular deformation of polymer capsules using structured illumination microscopy

Xi Chen, Jiwei Cui, Huanli Sun, Markus Mullner, Yan Yan, Ka Fung Noi, Yuan Ping, Frank Caruso

2016-01-01

Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are process..

A novel cross-linked nano-coating for carbon dioxide capture

Q Fu, J Kim, PA Gurr, JMP Scofield, SE Kentish, GG Qiao

2016-01-01

Ultra-thin ([similar]100 nm) films with uniform thicknesses can facilitate high CO2 permeation and are of potential technological ..

Probing cell internalisation mechanics with polymer capsules

Xi Chen, Jiwei Cui, Yuan Ping, Tomoya Suma, Francesca Cavalieri, Quinn A Besford, George Chen, Julia A Braunger, Frank Caruso

2016-01-01

We report polymer capsule-based probes for quantifying the pressure exerted by cells during capsule internalisation (Pin). Poly(me..

Ultra-thin film composite mixed matrix membranes incorporating iron(III)-dopamine nanoparticles for CO2 separation

Jinguk Kim, Qiang Fu, Joel MP Scofield, Sandra E Kentish, Greg G Qiao

2016-01-01

Iron dopamine nanoparticles (FeDA NPs) are incorporated into a nanoscale thick polyethylene glycol (PEG) matrix for the first time..

Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso

2015-11-01

Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Sylvia T Gunawan, Kristian Kempe, Thomas Bonnard, Jiwei Cui, Karen Alt, Lok S Law, Xiaowei Wang, Erik Westein, Georgina K Such, Karlheinz Peter, Christoph E Hagemeyer, Frank Caruso

2015-09-16

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the su..

Formation and characterisation of a modifiable soft macro-porous hyaluronic acid cryogel platform

Timothy MA Henderson, Katharina Ladewig, David N Haylock, Keith M McLean, Andrea J O'Connor

2015-09-02

A facile method for the synthesis of cell supportive, highly macro-porous hyaluronic acid (HA) hydrogels via cryogelation is prese..

Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery

Steven J Shirbin, Katharina Ladewig, Qiang Fu, Molly Klimak, Xiaoqing Zhang, Wei Duan, Greg G Qiao

2015-08-01

Novel cisplatin (CDDP)-loaded, polypeptide-based vesicles for the targeted delivery of cisplatin to cancer cells have been prepare..

Redox-Sensitive PEG-Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells

Francesca Cavalieri, Giovanni L Beretta, Jiwei Cui, Julia A Braunger, Yan Yan, Joseph J Richardson, Stella Tinelli, Marco Folini, Nadia Zaffaroni, Frank Caruso

2015-07-01

We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs)...

Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Yi Ju, Jiwei Cui, Markus Muellner, Tomoya Suma, Ming Hu, Frank Caruso

2015-03-01

Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strat..

Engineering Poly(ethylene glycol) Particles for Improved Biodistribution

Jiwei Cui, Robert De Rose, Karen Alt, Sheilajen Alcantara, Brett M Paterson, Kang Liang, Ming Hu, Joseph J Richardson, Yan Yan, Charmaine M Jeffery, Roger I Price, Karlheinz Peter, Christoph E Hagemeyer, Paul S Donnelly, Stephen J Kent, Frank Caruso

2015-02-01

We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via t..

Generalizable Strategy for Engineering Protein Particles with pH-Triggered Disassembly and Recoverable Protein Functionality

Tomoya Suma, Jiwei Cui, Markus Muellner, Yi Ju, Junling Guo, Ming Hu, Frank Caruso

2015-02-01

Protein particles are promising candidates for therapeutic delivery. In this study, we report a generalizable strategy to assemble..

Versatile Loading of Diverse Cargo into Functional Polymer Capsules

Joseph J Richardson, James W Maina, Hirotaka Ejima, Ming Hu, Junling Guo, Mei Y Choy, Sylvia T Gunawan, Lien Lybaert, Christoph E Hagemeyer, Bruno G De Geest, Frank Caruso

2015-02-01

Polymer microcapsules are of particular interest for applications including self-healing coatings, catalysis, bioreactions, sensin..

Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs

Q Fu, J Xu, K Ladewig, TMA Henderson, GG Qiao

2015-01-07

Nontoxic and acid-degradable cross-linked polymeric vesicles as efficient nanocarriers for the delivery of platinum drugs are repo..

Amphiphilic core cross-linked star polymers as water-soluble, biocompatible and biodegradable unimolecular carriers for hydrophobic drugs

D Gu, K Ladewig, M Klimak, D Haylock, KM McLean, AJ O'Connor, GG Qiao

2015-01-01

Unimolecular polymeric architectures are ideal candidates for drug encapsulation. In this study we report the facile yet well-cont..

Cyclodextrin-based supramolecular polymeric nanoparticles for next generation gas separation membranes

Shereen Tan, Qiang Fu, Joel MP Scofield, Jinguk Kim, Paul A Gurr, Katharina Ladewig, Anton Blencowe, Greg G Qiao

2015-01-01

Cyclodextrin-based supramolecular assemblies derived from poly(dimethylsiloxane) (PDMS) functionalized polyrotaxanes (PRXs) were s..

Fabrication of ultra-thin polyrotaxane-based films via solid-state continuous assembly of polymers

Shereen Tan, Eunhyung Nam, Jiwei Cui, Chenglong Xu, Qiang Fu, Jing M Ren, Edgar HH Wong, Katharina Ladewig, Frank Caruso, Anton Blencowe, Greg G Qiao

2015-01-01

Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics..

Physicochemical and cytotoxicity analysis of glycerol monoolein-based nanoparticles

Terence E Hartnett, Katharina Ladewig, Andrea J O'Connor, Patrick G Hartley, Keith M McLean

2015-01-01

Lyotropic liquid crystalline dispersions, such as cubosomes, have been proposed as potential drug delivery vehicles. A recently de..

The role of capsule stiffness on cellular processing

Huanli Sun, Edgar HH Wong, Yan Yan, Jiwei Cui, Qiong Dai, Junling Guo, Greg G Qiao, Frank Caruso

2015-01-01

Particle stiffness is emerging as an important parameter in determining the cell uptake dynamics of particles. Understanding the e..

Tuning Particle Biodegradation through Polymer-Peptide Blend Composition

Sylvia T Gunawan, Kristian Kempe, Georgina K Such, Jiwei Cui, Kang Liang, Joseph J Richardson, Angus PR Johnston, Frank Caruso

2014-12-01

We report the preparation of polymer-peptide blend replica particles via the mesoporous silica (MS) templated assembly of poly(eth..

Super-Soft Hydrogel Particles with Tunable Elasticity in a Microfluidic Blood Capillary Model

Jiwei Cui, Mattias Bjoernmalm, Kang Liang, Chenglong Xu, James P Best, Xuehua Zhang, Frank Caruso

2014-11-19

Super-soft PEG hydrogel particles with tunable elasticity are prepared via a mesoporous silica templating method. The deformabilit..

The effect of soft nanoparticle morphologies on thin film composite membrane performance

Qiang Fu, Edgar HH Wong, Jinguk Kim, Joel MP Scofield, Paul A Gurr, Sandra E Kentish, Greg G Qiao

2014-11-14

Well-defined branched and densely cross-linked soft nanoparticles (SNPs) were synthesized and incorporated into a poly(ether-b-ami..

Convective polymer assembly for the deposition of nanostructures and polymer thin films on immobilized particles

Joseph J Richardson, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Kang Liang, Blaise Tardy, Shota Sekiguchi, Ka Fung Noi, Jiwei Cui, Hirotaka Ejima, Frank Caruso

2014-11-01

We report the preparation of polymer particles via convective polymer assembly (CPA). Convection is used to move polymer solutions..

Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs

James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso

2014-11-01

This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..

Engineering Enzyme-Cleavable Hybrid Click Capsules with a pH-Sheddable Coating for Intracellular Degradation

Sylvia T Gunawan, Kang Liang, Georgina K Such, Angus PR Johnston, Melissa KM Leung, Jiwei Cui, Frank Caruso

2014-10-29

The engineering of layer-by-layer (LbL) hybrid click capsules that are responsive to biological stimuli is reported. The capsules ..

Endocytic Capsule Sensors for Probing Cellular Internalization

Kang Liang, Sylvia T Gunawan, Joseph J Richardson, Georgina K Such, Jiwei Cui, Frank Caruso

2014-10-01

A new class of polymer capsules with an in-built endocytic pH-coupled fluorescence switch is reported. These capsules display reve..

Biodegradable and Biocompatible Poly(Ethylene Glycol)-based Hydrogel Films for the Regeneration of Corneal Endothelium

Berkay Ozcelik, Karl D Brown, Anton Blencowe, Katharina Ladewig, Geoffrey W Stevens, Jean-Pierre Y Scheerlinck, Keren Abberton, Mark Daniell, Greg G Qiao

2014-09-01

Corneal endothelial cells (CECs) are responsible for maintaining the transparency of the human cornea. Loss of CECs results in bli..

Continuous assembly of polymers via solid phase reactions

Eunhyung Nam, Jinguk Kim, Stefanie N Guntari, Helga Seyler, Qiang Fu, Edgar HH Wong, Anton Blencowe, David J Jones, Frank Caruso, Greg G Qiao

2014-09-01

The continuous assembly of polymers in the solid state via ring-opening metathesis polymerization (ssCAPROMP) is reported as an ef..

Fluidized Bed Layer-by-Layer Microcapsule Formation

Joseph J Richardson, Darwin Teng, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Jiwei Cui, George V Franks, Frank Caruso

2014-08-26

Polymer microcapsules can be used as bioreactors and artificial cells; however, preparation methods for cell-like microcapsules ar..

Size and Phase Control of Cubic Lyotropic Liquid Crystal Nanoparticles

Terence E Hartnett, Katharina Ladewig, Andrea J O'Connor, Patrick G Hartley, Keith M McLean

2014-07-03

The effective use of lyotropic liquid crystalline dispersions, such as cubosomes, as drug delivery vehicles requires that they hav..

Surface-Initiated Polymerization within Mesoporous Silica Spheres for the Modular Design of Charge-Neutral Polymer Particles

Markus Muellner, Jiwei Cui, Ka Fung Noi, Sylvia T Gunawan, Frank Caruso

2014-06-03

We report a templating approach for the preparation of functional polymer replica particles via surface-initiated polymerization i..

Highly porous and mechanically robust polyester poly(ethylene glycol) sponges as implantable scaffolds

Berkay Ozcelik, Anton Blencowe, Jason Palmer, Katharina Ladewig, Geoffrey W Stevens, Keren M Abberton, Wayne A Morrison, Greg G Qiao

2014-06-01

The development of suitable scaffolds plays a significant role in tissue engineering research. Although scaffolds with promising f..

Emerging methods for the fabrication of polymer capsules

Jiwei Cui, Martin P van Koeverden, Markus Muellner, Kristian Kempe, Frank Caruso

2014-05-01

Hollow polymer capsules are attracting increasing research interest due to their potential application as drug delivery vectors, s..

Soft Nanoparticles Assembled from Linear Poly( ethylene glycol) and Linear Brush Polydimethylsiloxane Diblock Copolymers

Andri Halim, Timothy D Reid, Jing M Ren, Qiang Fu, Paul A Gurr, Anton Blencowe, Sandra E Kentish, Greg G Qiao

2014-05-01

A series of novel amphiphilic diblock copolymers composed of hydrophilic linear poly(ethylene glycol) (PEG) and linear brush hydro..

Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles

Kang Liang, Joseph J Richardson, Hirotaka Ejima, Georgina K Such, Jiwei Cui, Frank Caruso

2014-04-01

A novel class of nanoparticles is developed for the co-delivery of a short cell penetrating peptide and a chemotherapeutic drug to..

Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules

Kang Liang, Georgina K Such, Angus PR Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso

2014-03-01

The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specif..

Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides

Jiwei Cui, Yi Ju, Kang Liang, Hirotaka Ejima, Samuel Loercher, Katelyn T Gause, Joseph J Richardson, Frank Caruso

2014-01-01

We report a versatile approach for the design of substrate-independent low-fouling surfaces via mussel-inspired immobilisation of ..

Peptide-Based Star Polymers as Potential siRNA Carriers

Shu Jie Lam, Adrian Sulistio, Katharina Ladewig, Edgar HH Wong, Anton Blencowe, Greg G Qiao

2014-01-01

16- and 32-arm star polymers were synthesised using poly(amido amine) (PAMAM) dendrimers as multifunctional initiators for the rin..

Soft polymeric nanoparticle additives for next generation gas separation membranes

Andri Halim, Qiang Fu, Qiwyn Yong, Paul A Gurr, Sandra E Kentish, Greg G Qiao

2014-01-01

This article highlights a new approach of fabricating a gas separation membrane through the addition of well-defined soft polymeri..

Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

Damien Mertz, Christine Affolter-Zbaraszczuk, Julien Barthes, Jiwei Cui, Frank Caruso, Thomas F Baumert, Jean-Claude Voegel, Joelle Ogier, Florent Meyer

2014-01-01

In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and g..

Immersive Polymer Assembly on Immobilized Particles for Automated Capsule Preparation

Joseph J Richardson, Kang Liang, Kristian Kempe, Hirotaka Ejima, Jiwei Cui, Frank Caruso

2013-12-01

We report a versatile approach for polymer capsule preparation using immobilized particles, which are immersed into polymer soluti..

Tuning the Mechanical Properties of Nanoporous Hydrogel Particles via Polymer Cross-Linking

James P Best, Jiwei Cui, Markus Muellner, Frank Caruso

2013-08-06

Soft hydrogel particles with tunable mechanical properties are promising for next-generation therapeutic applications. This is due..

One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering

Hirotaka Ejima, Joseph J Richardson, Kang Liang, James P Best, Martin P van Koeverden, Georgina K Such, Jiwei Cui, Frank Caruso

2013-07-12

The development of facile and versatile strategies for thin-film and particle engineering is of immense scientific interest. Howev..

Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

Jiwei Cui, Robert De Rose, James P Best, Angus PR Johnston, Sheilajen Alcantara, Kang Liang, Georgina K Such, Stephen J Kent, Frank Caruso

2013-07-05

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elast..

A novel one-pot approach towards dynamically cross-linked hydrogels

Shereen Tan, Anton Blencowe, Katharina Ladewig, Greg G Qiao

2013-01-01

Herein, we report the synthesis of sliding-ring (SR) hydrogel networks in a one-pot click-mediated approach using α,ω-dialkyne pol..

Cryogels for biomedical applications

Timothy MA Henderson, Katharina Ladewig, David N Haylock, Keith M McLean, Andrea J O'Connor

2013-01-01

The use of hydrogels as support materials for the growth and proliferation of mammalian cells has been well documented as they clo..

Highly permeable membrane materials for CO2 capture

Qiang Fu, Andri Halim, Jinguk Kim, Joel MP Scofield, Paul A Gurr, Sandra E Kentish, Greg G Qiao

2013-01-01

The release of large quantities of CO2 into the atmosphere has been linked to global warming and climate anomalies. Membrane proce..

Templated Assembly of pH-Labile Polymer-Drug Particles for Intracellular Drug Delivery

Jiwei Cui, Yan Yan, Yajun Wang, Frank Caruso

2012-11-21

The preparation of pH-labile polymer-drug particles via mesoporous silica-templated assembly for anticancer drug delivery into can..

Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules

Jiwei Cui, Yan Yan, Georgina K Such, Kang Liang, Christopher J Ochs, Almar Postma, Frank Caruso

2012-08-01

We report a facile approach to immobilize pH-cleavable polymer-drug conjugates in mussel-inspired polydopamine (PDA) capsules for ..