SOMATOSTAIN & STRESS-RELATED GENES IN HIV & COMORBID MAJOR DEPRESSIVE DISORDER

Molecular and pathologic insights from latent HIV-1 infection in the human brain

Paula Desplats, Wilmar Dumaop, David Smith, Anthony Adame, Ian Everall, Scott Letendre, Ronald Ellis, Mariana Cherner, Igor Grant, Eliezer Masliah

2013-04-01

OBJECTIVE: We aimed to investigate whether HIV latency in the CNS might have adverse molecular, pathologic, and clinical consequen..

The spatial relationship between neurons and astrocytes in HIV-associated dementia

Eleanor S Roberts, Gursharan Chana, Timothy B Nguyen, Gayathri Perera, Sabine Landau, Sophia Rabe-Hesketh, Jonathan D Glass, Justin McArthur, Ian Paul Everall

2013-04-01

Specific neuronal spatial distributional patterns have previously been correlated with increasing severity of HIV-associated demen..

Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder

Benchawanna Soontornniyomkij, Ian P Everall, Gursharan Chana, Ming T Tsuang, Cristian L Achim, Virawudh Soontornniyomkij

2011-10-01

BACKGROUND: The role of the cerebellum in coordinating mental activity is supported by its connections with cerebral regions invol..

Increased CDK5 Expression in HIV Encephalitis Contributes to Neurodegeneration via Tau Phosphorylation and Is Reversed with Roscovitine

Christina Patrick, Leslie Crews, Paula Desplats, Wilmar Dumaop, Edward Rockenstein, Cristian L Achim, Ian P Everall, Eliezer Masliah

2011-04-01

Recent treatments with highly active antiretroviral therapy (HAART) regimens have been shown to improve general clinical status in..

Methamphetamine-Associated Psychosis: A Model for Biomarker Discovery in Schizophrenia

Chad A Bousman, Stephen J Glatt, Ian P Everall, Ming T Tsuang

2011-01-01

Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals

Erick T Tatro, Timothy B Nguyen, Chad A Bousman, Eliezer Masliah, Igor Grant, J Hampton Atkinson, Ian P Everall

2010-10-01

Major depressive disorder (MDD) is a significant cause of morbidity in people living with the human immunodeficiency virus (HIV). ..

Positive Symptoms of Psychosis Correlate With Expression of Ubiquitin Proteasome Genes in Peripheral Blood

Chad A Bousman, Gursharan Chana, Stephen J Glatt, Sharon D Chandler, Todd May, James Lohr, William S Kremen, Ming T Tsuang, Ian P Everall

2010-10-01

Several brain- and blood-based gene expression studies in patients with psychotic disorders (e.g., schizophrenia) have identified ..

Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain: Novel Analysis of Retrospective Cases

Erick T Tatro, Erick R Scott, Timothy B Nguyen, Shahid Salaria, Sugato Banerjee, David J Moore, Eliezer Masliah, Cristian L Achim, Ian P Everall

2010-04-26

HIV infection disturbs the central nervous system (CNS) through inflammation and glial activation. Evidence suggests roles for mic..

Preliminary Evidence of Ubiquitin Proteasome System Dysregulation in Schizophrenia and Bipolar Disorder: Convergent Pathway Analysis Findings from Two Independent Samples

Chad A Bousman, Gursharan Chana, Stephen J Glatt, Sharon D Chandler, Ginger R Lucero, Erick Tatro, Todd May, James B Lohr, William S Kremen, Ming T Tsuang, Ian P Everall

2010-03-01

Schizophrenia (SCZ) and bipolar disorder (BPD) are polygenic disorders with many genes contributing to their etiologies. The aim o..

Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy

I Everall, F Vaida, N Khanlou, D Lazzaretto, C Achim, S Letendre, D Moore, R Ellis, M Cherner, B Gelman, S Morgello, E Singer, I Grant, E Masliah

2009-10-01

The objective of this study was to examine the spectrum of human immunodeficiency virus (HIV) brain pathology and its clinical cor..

Glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons

Timothy B Nguyen, Ginger R Lucero, Gursharan Chana, Britta J Hult, Erick T Tatro, Eliezer Masliah, Igor Grant, Cristian L Achim, Ian P Everall

2009-10-01

Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidence..

Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study.

SJ Glatt, SD Chandler, CA Bousman, G Chana, GR Lucero, E Tatro, T May, JB Lohr, WS Kremen, IP Everall, MT Tsuang

2009-09-01

OBJECTIVE: Transcriptomic biomarkers of psychiatric diseases obtained from a query of peripheral tissues that are clinically acces..

Upregulation of NRG-1 and VAMP-1 in human brain aggregates exposed to clozapine

Gursharan Chana, Ginger Lucero, Shahid Salaria, Jean Lozach, Pinyi Du, Christopher Woelk, Ian Everall

2009-09-01

Growing genetic evidence has implicated a role for neuregulin-1 (NRG-1) in schizophrenia pathogenesis as well as alterations in SN..

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

Erick T Tatro, Ian P Everall, Marcus Kaul, Cristian L Achim

2009-08-25

Mood disorders associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis are common psychiatric conditions. The..

Differential Expression of Immunophilins FKBP51 and FKBP52 in the Frontal Cortex of HIV-Infected Patients with Major Depressive Disorder

Erick T Tatro, Ian P Everall, Eliezer Masliah, Britta J Hult, Ginger Lucero, Gursharan Chana, Virawudh Soontornniyomkij, Cristian L Achim

2009-06-01

Patients infected with human immunodeficiency virus (HIV) have a higher risk of developing major depressive disorder (MDD) than th..

Increased Accumulation of Intraneuronal Amyloid beta in HIV-Infected Patients

Cristian L Achim, Anthony Adame, Wilmar Dumaop, Ian P Everall, Eliezer Masliah

2009-06-01

In recent years, human immunodeficiency virus (HIV)-infected patients under highly active anti-retroviral therapy (HAART) regimens..

Molecular Pathology of Neuro-AIDS (CNS-HIV)

Leslie Crews, Christina Patrick, Cristian L Achim, Ian P Everall, Eliezer Masliah

2009-03-01

The cognitive deficits in patients with HIV profoundly affect the quality of life of people living with this disease and have ofte..