CENTRE FOR TRANSLATIONAL NEUROSCIENCE: A MODULAR PLATFORM FOR TRANSLATING DISCOVERY INTO HEALTH OUTCOMES

Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

Melissa M Gresle, Margaret A Jordan, Jim Stankovich, Tim Spelman, Laura J Johnson, Louise Laverick, Alison Hamlett, Letitia D Smith, Vilija G Jokubaitis, Josephine Baker, Jodi Haartsen, Bruce Taylor, Jac Charlesworth, Melanie Bahlo, Terence P Speed, Matthew A Brown, Judith Field, Alan G Baxter, Helmut Butzkueven

2020-07-01

At least 200 single-nucleotide polymorphisms (SNPs) are associated with multiple sclerosis (MS) risk. A key function that could me..

Association of Inflammation and Disability Accrual in Patients With Progressive-Onset Multiple Sclerosis

Jordana Hughes, Vilija Jokubaitis, Alessandra Lugaresi, Raymond Hupperts, Guillermo Izquierdo, Alexandre Prat, Marc Girard, Pierre Duquette, Francois Grand'Maison, Pierre Grammond, Patrizia Sola, Diana Ferraro, Cristina Ramo-Tello, Maria Trojan, Mark Slee, Vahid Shaygannejad, Cavit Boz, Jeanette Lechner-Scott, Vincent Van Pesch, Eugenio Pucci

2018-11-01

Importance: The role of inflammatory disease activity as a determinant of disability in progressive-onset multiple sclerosis (MS) ..

Timing of high-efficacy therapy in relapsing-remitting multiple sclerosis: A systematic review

Bernd Merkel, Helmut Butzkueven, Anthony L Traboulsee, Eva Havrdova, Tomas Kalincik

2017-06-01

BACKGROUND: Immunotherapy initiated early after first presentation of relapsing-remitting multiple sclerosis is associated with im..

Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study

Tomas Kalincik, J William L Brown, Neil Robertson, Mark Willis, Neil Scolding, Claire M Rice, Alastair Wilkins, Owen Pearson, Tjalf Ziemssen, Michael Hutchinson, Christopher McGuigan, Vilija Jokubaitis, Tim Spelman, Dana Horakova, Eva Havrdova, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Alexandre Prat, Marc Girard

2017-04-01

BACKGROUND: Alemtuzumab, an anti-CD52 antibody, is proven to be more efficacious than interferon beta-1a in the treatment of relap..

Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis

Nathaniel Lizak, Alessandra Lugaresi, Raed Alroughani, Jeannette Lechner-Scott, Mark Slee, Eva Havrdova, Dana Horakova, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Alexandre Prat, Pierre Grammond, Raymond Hupperts, Francois Grand'Maison, Patrizia Sola, Eugenio Pucci, Roberto Bergamaschi, Celia Oreja-Guevara, Vincent Van Pesch

2017-03-01

OBJECTIVE: To evaluate variability and predictability of disability trajectories in moderately advanced and advanced multiple scle..

Defining secondary progressive multiple sclerosis

Johannes Lorscheider, Katherine Buzzard, Vilija Jokubaitis, Tim Spelman, Eva Havrdova, Dana Horakova, Maria Trojano, Guillermo Izquierdo, Marc Girard, Pierre Duquette, Alexandre Prat, Alessandra Lugaresi, Francois Grand'Maison, Pierre Grammond, Raymond Hupperts, Raed Alroughani, Patrizia Sola, Cavit Boz, Eugenio Pucci, Jeanette Lechner-Scott

2016-09-01

The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts

Sandra J Petty, Carol J Milligan, Marian Todaro, Kay L Richards, Pamuditha K Kularathna, Charles N Pagel, Chris R French, Elisa L Hill-Yardin, Terence J O'Brien, John D Wark, Eleanor J Mackie, Steven Petrou

2016-09-01

OBJECTIVE: Fracture risk is a serious comorbidity in epilepsy and may relate to the use of antiepileptic drugs (AEDs). Many AEDs i..

Predictors of Long-Term Disability Accrual in Relapse-Onset Multiple Sclerosis

Vilija G Jokubaitis, Tim Spelman, Tomas Kalincik, Johannes Lorscheider, Eva Havrdova, Dana Horakova, Pierre Duquette, Marc Girard, Alexandre Prat, Guillermo Izquierdo, Pierre Grammond, Vincent Van Pesch, Eugenio Pucci, Francois Grand'Maison, Raymond Hupperts, Franco Granella, Patrizia Sola, Roberto Bergamaschi, Gerardo Iuliano, Daniele Spitaleri

2016-07-01

OBJECTIVE: To identify predictors of 10-year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients..

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Tim Spelman, Orla Gray, Robyn Lucas, Helmut Butzkueven

2015-12-01

This report describes a novel Stata-based application of trigonometric regression modelling to 55 years of multiple sclerosis rela..

Mind the gap: Multiple events and lengthy delays before presentation with a "first seizure"

Anna L Firkin, David JT Marco, Sibel Saya, Mark R Newton, Terence J O'Brien, Samuel F Berkovic, Anne M McIntosh

2015-10-01

OBJECTIVE: Up to half of patients assessed for suspected new-onset epileptic seizures report previous undiagnosed events. This sug..

SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia

M Udawela, TT Money, J Neo, MS Seo, E Scarr, B Dean, IP Everall

2015-08-04

Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from..

Galanin is an Autocrine Myelin and Oligodendrocyte Trophic Signal Induced by Leukemia Inhibitory Factor

Melissa M Gresle, Helmut Butzkueven, Victoria M Perreau, Anna Jonas, Junhua Xiao, Stefan Thiem, Fiona E Holmes, William Doherty, Pik-Ying Soo, Michele D Binder, Rainer Akkermann, Vilija G Jokubaitis, Holly S Cate, Mark P Marriott, Andrew L Gundlach, David Wynick, Trevor J Kilpatrick

2015-06-01

In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC) survival, we utilized microarrays to c..

Comparison of Switch to Fingolimod or Interferon Beta/Glatiramer Acetate in Active Multiple Sclerosis

Anna He, Tim Spelman, Vilija Jokubaitis, Eva Havrdova, Dana Horakova, Maria Trojano, Alessandra Lugaresi, Guillermo Izquierdo, Pierre Grammond, Pierre Duquette, Marc Girard, Eugenio Pucci, Gerardo Iuliano, Raed Alroughani, Celia Oreja-Guevara, Ricardo Fernandez-Bolanos, Francois Grand'Maison, Patrizia Sola, Daniele Spitaleri, Franco Granella

2015-04-01

IMPORTANCE: After multiple sclerosis (MS) relapse while a patient is receiving an injectable disease-modifying drug, many physicia..

Switch to Natalizumab versus Fingolimod in Active Relapsing-Remitting Multiple Sclerosis

Tomas Kalincik, Dana Horakova, Tim Spelman, Vilija Jokubaitis, Maria Trojano, Alessandra Lugaresi, Guillermo Izquierdo, Csilla Rozsa, Pierre Grammond, Raed Alroughani, Pierre Duquette, Marc Girard, Eugenio Pucci, Jeannette Lechner-Scott, Mark Slee, Ricardo Fernandez-Bolanos, Francois Grand'Maison, Raymond Hupperts, Freek Verheul, Suzanne Hodgkinson

2015-03-01

OBJECTIVE: In patients suffering multiple sclerosis activity despite treatment with interferon β or glatiramer acetate, clinicians..

Single live cell TGF-beta signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-beta-Smad3 activity

Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu

2015-02-22

BACKGROUND: Metastasis is a process where only a small subset of cells is capable of successfully migrating to and propagating at ..

Seasonal Variation of Relapse Rate in Multiple Sclerosis is Latitude Dependent

Tim Spelman, Orla Gray, Maria Trojano, Thor Petersen, Guillermo Izquierdo, Alessandra Lugaresi, Raymond Hupperts, Roberto Bergamaschi, Pierre Duquette, Pierre Grammond, Giorgio Giuliani, Cavit Boz, Freek Verheul, Celia Oreja-Guevara, Michael Barnett, Francois Grand'Maison, Maria Edite Rio, Jeannette Lechner-Scott, Vincent Van Pesch, Ricardo Fernandez Bolanos

2014-12-01

OBJECTIVE: Previous studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Smal..

Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation

Anna Jonas, Stefan Thiem, Tanja Kuhlmann, Raimund Wagener, Attila Aszodi, Cameron Nowell, Mann Hagemeier, Louise Laverick, Victoria Perreau, Vilija Jokubaitis, Ben Emery, Trevor Kilpatrick, Helmut Butzkueven, Melissa Gresle

2014-11-01

In patients with multiple sclerosis (MS) and mice with experimental autoimmune encephalomyelitis (EAE), inflammatory axonal injury..

Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

MM Gresle, Y Liu, LF Dagley, J Haartsen, F Pearson, AW Purcell, L Laverick, A Petzold, RM Lucas, A Van der Walt, H Prime, DR Morris, BV Taylor, G Shaw, H Butzkueven

2014-11-01

OBJECTIVES: We evaluated whether the measurement of serum phosphorylated neurofilament heavy chain (pNF-H) titre is likely to be a..

Weight and fat distribution in patients taking valproate: A valproate-discordant gender-matched twin and sibling pair study

Sandra J Petty, Susan Kantor, Kate M Lawrence, Samuel F Berkovic, Marnie Collins, Keith D Hill, Joanna Makovey, Philip N Sambrook, Terence J O'Brien, John D Wark

2014-10-01

OBJECTIVES: Chronic treatment with valproate (VPA) is commonly associated with weight gain, which potentially has important health..

Sex as a determinant of relapse incidence and progressive course of multiple sclerosis

Tomas Kalincik, Vino Vivek, Vilija Jokubaitis, Jeannette Lechner-Scott, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Francois Grand'Maison, Raymond Hupperts, Celia Oreja-Guevara, Roberto Bergamaschi, Gerardo Iuliano, Raed Alroughani, Vincent Van Pesch, Maria Pia Amato, Mark Slee, Freek Verheul, Ricardo Fernandez-Bolanos, Marcela Fiol, Daniele La Spitaleri

2013-12-01

The aim of this work was to evaluate sex differences in the incidence of multiple sclerosis relapses; assess the relationship betw..

Warfarin-associated intracerebral hemorrhage: Volume, anticoagulation intensity and location

Minmin Ma, Atte Meretoja, Leonid Churilov, Gagan J Sharma, Soren Christensen, Xinfeng Liu, Louise Weir, Stephen M Davis, Bernard Yan

2013-09-15

BACKGROUND: Warfarin use increases mortality in patients with intracerebral hemorrhage (ICH). Larger hematoma volume and infratent..

The role of Stat3 in glioblastoma multiforme

Rodney B Luwor, Stanley S Stylli, Andrew H Kaye

2013-07-01

Glioblastoma multiforme (GBM) is the most common brain tumor and has the worst prognosis. Several signaling molecules have been cl..

Health-related quality of life as an independent predictor of long-term disability for patients with relapsingremitting multiple sclerosis

K Baumstarck, J Pelletier, H Butzkueven, O Fernandez, P Flachenecker, E Idiman, S Stecchi, M Boucekine, P Auquier

2013-06-01

BACKGROUND AND PURPOSE: Predictive factors of long-term disability in patients with relapsing-remitting multiple sclerosis (RR-MS)..

A double-blind, randomized, controlled study of botulinum toxin type A in MS-related tremor

Anneke Van der Walt, Simon Sung, Timothy Spelman, Mark Marriott, Scott Kolbe, Peter Mitchell, Andrew Evans, Helmut Butzkueven

2012-07-01

OBJECTIVE: To evaluate the safety and efficacy of botulinum toxin type A in disabling multiple sclerosis (MS)-related upper limb t..