THE BIOLOGY AND THERAPEUTIC MANIPULATION OF LYMPHATIC VESSELS IN HUMAN DISEASE
Grant number: 487900 | Funding period: 2010 - 2012
This proposal is for an established team of researchers and clinicians to explore the molecular control of the lymphatic system. This network of lymphatic vessels, located in organs throughout the body, is critical for regulation of tissue fluid and immune function. This program will explore the molecules which control the function of lymphatic vessels and their interactions with other cells in the body. It will greatly enhance our understanding of the lymphatic vessels and identify molecular targets for medicines designed to treat cancer, cardiovascular disease and lymphoedema.
Related publications (3)
CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker
Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymph..
Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Dane Cheasley, Lloyd Pereira, Shienny Sampurno, Oliver Sieber, Robert Jorissen, Huiling Xu, Markus Germann, Yuqian Yan, Robert G Ramsay, Jordane Malaterre
UNLABELLED: Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (Myb(P..
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis
Ludovic Le Guen, Terhi Karpanen, Dorte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Bower, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan
The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation of lymphatic vessels from pre-existing vascul..