THE BIOLOGY AND THERAPEUTIC MANIPULATION OF LYMPHATIC VESSELS IN HUMAN DISEASE
Grant number: 487900 | Funding period: 2010 - 2012
This proposal is for an established team of researchers and clinicians to explore the molecular control of the lymphatic system. This network of lymphatic vessels, located in organs throughout the body, is critical for regulation of tissue fluid and immune function. This program will explore the molecules which control the function of lymphatic vessels and their interactions with other cells in the body. It will greatly enhance our understanding of the lymphatic vessels and identify molecular targets for medicines designed to treat cancer, cardiovascular disease and lymphoedema.
Related publications (2)
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis
Ludovic Le Guen, Terhi Karpanen, Dorte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Bower, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan