FIBROBLAST FUNCTION IN UTERINE LEIOMYOMA
Grant number: 606613 | Funding period: 2010 - 2012
Uterine fibroids are benign tumors that occur in up to 77% of reproductive age women. They can result in a range of symptoms including pain and excessive menstrual bleeding and are the commonest single reason for hysterectomy. This project will investigate the function of the different cell types that make up the fibroid. Knowledge gained will be of use to identify new targets for treating fibroids to reduce the need for hysterectomy.
Related publications (5)
Differences in the cellular composition of small versus large uterine fibroids
Sarah J Holdsworth-Carson, Dong Zhao, Leonie Cann, Sophie Bittinger, Cameron J Nowell, Peter AW Rogers
Uterine fibroids are clonally derived from a single cell; however, despite being monoclonal, the cellular phenotypes that make up ..
Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium
Sarah J Holdsworth-Carson, Marina Zaitseva, Jane E Girling, Beverley J Vollenhoven, Peter AW Rogers
Uterine fibroids are a prevalent gynaecological condition in reproductive-aged women and are the commonest reason for hysterectomy..
Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues
Sarah J Holdsworth-Carson, Marina Zaitseva, Beverley J Vollenhoven, Peter AW Rogers
Uterine fibroids are conventionally defined as clonally derived benign tumours from the proliferation of a single smooth muscle ce..
Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids
Marina Zaitseva, Sarah J Holdsworth-Carson, Luke Waldrip, Julia Nevzorova, Luciano Martelotto, Beverley J Vollenhoven, Peter AW Rogers
Uterine fibroids are the most common benign tumour afflicting women of reproductive age. Despite the large healthcare burden cause..
Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles
Sophia E Tsiligiannis, Marina Zaitseva, Peter R Coombs, Paul Shekleton, Moshe Olshansky, Martha Hickey, Beverley Vollenhoven, Peter AW Rogers
Despite the prevalence of uterine fibroids (Fs), few studies have investigated the links between clinical features and the cellula..