The Potential Of Bace As A Blood Biomarker For Early Detection Of Alzheimer'S Disease

Grant number: 12116 | Funding period: 2010 - 2012

Completed

Abstract

With support from two successive, framework V, EU sponsored consortia, we have developed a targeted immunodeficiency virus-like particle vaccine (VLP) which has the G-protein of vesicular stomatitis virus incorporated in the membrane of the particle. This should increase uptake and presentation of VLPs by dendritic cells. A pilot vaccination experiment in the SIV/macaque model provided strong protection against challenge with a pathogenic SIV. Given the urgent need for an HIV vaccine, the potential of this innovative vaccine approach should be evaluated as quickly as possible. Therefore, the aims of the current STREP application of the consortium are 1) to determine the efficacy of the VLPs ..

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