CHARACTERISING AND VISUALISING CROSS-PRESENTING DENDRITIC CELLS FOLLOWING CUTANEOUS VACCINIA INFECTION
Grant number: 1013641 | Funding period: 2011 - 2016
Live imaging of cells within lymphoid organs provides a valuable tool allowing insight into how immune responses are initiated. Utilising novel reagents we will visualise and define these events following cutaneous infection with vaccinia virus.
Related publications (6)
Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells
Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui
Resolution of virus infections depends on the priming of virus-specific CD8+ T cells by dendritic cells (DC). While this process r..
T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming
Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui
DCs often require stimulation from CD4(+) T cells to propagate CD8(+) T cell responses, but precisely how T cell help optimizes th..
Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection
Paul G Whitney, Eva Baer, Fabiola Osorio, Neil C Rogers, Barbara U Schraml, Safia Deddouche, Salome LeibundGut-Landmann, Caetano Reis e Sousa
Host protection from fungal infection is thought to ensue in part from the activity of Syk-coupled C-type lectin receptors and MyD..
IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells
Eva Baer, Paul G Whitney, Kathrin Moor, Caetano Reis e Sousa, Salome LeibundGut-Landmann
Interleukin 17 (IL-17)-mediated immunity plays a key role in protection from fungal infections in mice and man. Here, we confirmed..
Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage
Barbara U Schraml, Janneke van Blijswijk, Santiago Zelenay, Paul G Whitney, Andrew Filby, Sophie E Acton, Neil C Rogers, Natalia Moncaut, Jaime J Carvajal, Caetano Reis e Sousa
Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on cell morphology, phenotype, or select funct..
The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
Santiago Zelenay, Anna M Keller, Paul G Whitney, Barbara U Schraml, Safia Deddouche, Neil C Rogers, Oliver Schulz, David Sancho, Caetano Reis e Sousa
DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is cur..