Better T Cells For Cancer Therapy
Grant number: 1006188 | Funding period: 2011 - 2013
White blood cells from cancer patients can be modified in the laboratory to react against tumours. These cells can then be given back to the patient, which can sometimes cause cancer regression. However, often the white blood cells lack strength, or they lack the ability to distinguish between tumour and normal tissues of the body. In this project we seek to make stronger and smarter white blood cells that can deliver a lethal hit against tumours without damaging essential organs of the body.
Related publications (5)
Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor
Melissa A Henderson, Carmen SM Yong, Connie PM Duong, Alexander J Davenport, Liza B John, Christel Devaud, Paul Neeson, Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw