Role of gastrin prohormones in the development of gastrointestinal cancers
Grant number: 1006245 | Funding period: 2011 - 2013
Gastrin is a stomach hormone which increases acid secretion and the growth of the stomach and bowel. This growth promoting effect may be involved in a number of cancers particularly colon cancer. The different types of gastrin have different effects but we do not know which forms are important and whether all are active. The types and activity of different gastrins will be investigated using cell lines, animal models and colon cancer patients with the view of establishing new treatments.
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The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo
Kathryn M Marshall, Oneel Patel, Gianni Bramante, Marie Laval, Mildred Yim, Graham S Baldwin, Arthur Shulkes
Progastrin (PG) is processed into a number of smaller peptides including amidated gastrin (Gamide), non-amidated glycine-extended ..