A DENDRITIC CELL SUBSET TARGETING APPROACH FOR GENERATING HUMORAL IMMUNITY

Grant number: 1003355 | Funding period: 2011 - 2013

Completed

Abstract

Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We show that targeting these special cells by using monoclonal antibodies that recognise Clec9A is effective, perhaps because it brings several different immune cells together so that they orchestrate very efficient immune responses. This application investigates how targeting Clec9A allows strong vaccination so that we can apply this to new generation vaccines.