Therapeutic targeting of stem cells that cause leukaemia
Grant number: 1003391 | Funding period: 2011 - 2011
We have recently identified a stem cell population causes T cell leukaemia. These cells may also survive conventional leukaemia therapies and cause relapse. This project will determine whether these stem cells can be killed using conventional leukaemia therapeutics. In addition, we will identify new therapeutic targets to eliminate these cells. This will enable us to specifically target the cells responsible for leukaemia relapse.
Related publications (6)
Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack
The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knoc..
Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a
Jacob T Jackson, Benjamin J Shields, Wei Shi, Ladina Di Rago, Donald Metcalf, Nicos A Nicola, Matthew P McCormack
The hematopoietically expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic p..
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a
Benjamin J Shields, Jacob T Jackson, Donald Metcalf, Wei Shi, Qiutong Huang, Alexandra L Garnham, Stefan P Glaser, Dominik Beck, John E Pimanda, Clifford W Bogue, Gordon K Smyth, Warren S Alexander, Matthew P McCormack
Unlike clustered HOX genes, the role of nonclustered homeobox gene family members in hematopoiesis and leukemogenesis has not been..
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice
BJ Shields, R Alserihi, C Nasa, C Bogue, WS Alexander, MP McCormack
Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute leukemias, in particular poor prognosis..
A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis
Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas D Huntington, Clifford W Bogue, Warren S Alexander, Matthew P McCormack
The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hem..
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL
Matthew P McCormack, Benjamin J Shields, Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas J Slater, Cedric S Tremblay, Terence H Rabbitts, David J Curtis
Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), includi..