A new strategy for treating persistent diarrhoea
Grant number: 1008853 | Funding period: 2011 - 2013
Enteropathogenic E. coli (EPEC) cause acute and persistent diarrhoea which affect the health of millions of children each year. In this study, we will use the state-of-the-art-technology to identify small synthetic-compounds that inhibit the virulence of EPEC without affecting normal microflora. Molecular, cellular and animal tests of the compounds will be carried out to determine whether they can be used to treat gastrointestinal infection by EPEC.
Related publications (1)
Control of Acid Resistance Pathways of Enterohemorrhagic Escherichia coli Strain EDL933 by PsrB, a Prophage-Encoded AraC-Like Regulator
Ji Yang, Thomas W Russell, Dianna M Hocking, Jennifer K Bender, Yogitha N Srikhanta, Marija Tauschek, Roy M Robins-Browne
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes bloody diarrhea and hemolytic-uremic syndrome (HUS) and is the most preva..