The diamond cohort study - long term outcomes of depressive
Grant number: 1002908 | Funding period: 2011 - 2016
Diamond began in 2005 to follow over 500 people with depressive symptoms to document and describe the nature and course of depression and its’ management over a decade of a participant’s life. Our findings will help us to understand the factors associated with depression recovery, relapse and persistence. We will inform clinical practice by developing a tool to assist GPs to identify those at risk of persistent and disabling depression, to enable better treatments.
Related publications (24)
Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial
Susan Fletcher, Patty Chondros, Konstancja Densley, Elizabeth Murray, Christopher Dowrick, Amy Coe, Kelsey Hegarty, Sandra Davidson, Caroline Wachtler, Cathrine Mihalopoulos, Yong Yi Lee, Mary Lou Chatterton, Victoria J Palmer, Jane Gunn
BACKGROUND: Mental health treatment rates are increasing, but the burden of disease has not reduced. Tools to support efficient re..
Link-me: Protocol for a randomised controlled trial of a systematic approach to stepped mental health care in primary care
Susan Fletcher, Patty Chondros, Victoria J Palmer, Mary Lou Chatterton, Matthew J Spittal, Cathrine Mihalopoulos, Anna Wood, Meredith Harris, Philip Burgess, Bridget Bassilios, Jane Pirkis, Jane Gunn
Primary care in Australia is undergoing significant reform, with a particular focus on cost-effective tailoring of mental health c..
Exploring comorbid depression and physical health trajectories: A case-based computational modelling approach
Brian Castellani, Frances Griffiths, Rajeev Rajaram, Jane Gunn
While comorbid depression/physical health is a major clinical concern, the conventional methods of medicine make it difficult to m..
Development of a Mobile Clinical Prediction Tool to Estimate Future Depression Severity and Guide Treatment in Primary Care: User-Centered Design
Caroline Wachtler, Amy Coe, Sandra Davidson, Susan Fletcher, Antonette Mendoza, Leon Sterling, Jane Gunn
BACKGROUND: Around the world, depression is both under- and overtreated. The diamond clinical prediction tool was developed to ass..
Development of a prognostic model for predicting depression severity in adult primary patients with depressive symptoms using the diamond longitudinal study
Patty Chondros, Sandra Davidson, Rory Wolfe, Gail Gilchrist, Christopher Dowrick, Frances Griffiths, Kelsey Hegarty, Helen Herrman, Jane Gunn
BACKGROUND: Depression trajectories among primary care patients are highly variable, making it difficult to identify patients that..
Uptake of mental health websites in primary care: Insights from an Australian longitudinal cohort study of depression
Jane Gunn, Jacqui Cameron, Konstancja Densley, Sandra Davidson, Susie Fletcher, Victoria Palmer, Patty Chondros, Christopher Dowrick, Jane Pirkis
OBJECTIVE: To describe the characteristics of primary care attendees with depressive symptoms who use mental health websites. METH..
Target-D: a stratified individually randomized controlled trial of the diamond clinical prediction tool to triage and target treatment for depressive symptoms in general practice: study protocol for a randomized controlled trial
Jane Gunn, Caroline Wachtler, Susan Fletcher, Sandra Davidson, Cathrine Mihalopoulos, Victoria Palmer, Kelsey Hegarty, Amy Coe, Elizabeth Murray, Christopher Dowrick, Gavin Andrews, Patty Chondros
BACKGROUND: Depression is a highly prevalent and costly disorder. Effective treatments are available but are not always delivered ..
Polygenic phenotypic plasticity moderates the effects of severe childhood abuse on depressive symptom severity in adulthood: A 5-year prospective cohort study
Chad A Bousman, Jane M Gunn, Maria Potiriadis, Ian P Everall
Objective To test the phenotypic plasticity framework using a polygenic approach in a prospective depression cohort of primary car..
The Health Service Use of Frequent Users of Telephone Helplines in a Cohort of General Practice Attendees with Depressive Symptoms
Aves Middleton, Jane Pirkis, Patty Chondros, Bridget Bassilios, Jane Gunn
We examined the relationship between frequent use of telephone helplines and health service use over time in a cohort of 789 gener..
The Brain-Derived neurotrophic Factor Val66Met Polymorphism Moderates the effects of childhood abuse on severity of Depressive symptoms in a Time-Dependent Manner
Caitlin Webb, Jane M Gunn, Maria Potiriadis, Ian P Everall, Chad A Bousman
Cross-sectional studies have demonstrated that the brain-derived neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphis..
Impact of functional and structural social relationships on two year depression outcomes: A multivariate analysis
Sandra K Davidson, Christopher F Dowrick, Jane M Gunn
BACKGROUND: High rates of persistent depression highlight the need to identify the risk factors associated with poor depression ou..
Mental health interventions and future major depression among primary care patients with subthreshold depression
Sandra K Davidson, Meredith G Harris, Christopher F Dowrick, Caroline A Wachtler, Jane Pirkis, Jane M Gunn
BACKGROUND: Subthreshold depression is prevalent in primary care and is associated with poorer quality of life, higher health care..
What factors influence long-term antidepressant use in primary care? Findings from the Australian diamond cohort study
Gilles Ambresin, Victoria Palmer, Konstancja Densley, Christopher Dowrick, Gail Gilchrist, Jane M Gunn
BACKGROUND: Antidepressants are one of the most commonly prescribed drugs in primary care. The rise in use is mostly due to an inc..
Factors associated with smoking and smoking cessation among primary care patients with depression: a naturalistic cohort study
Gail Gilchrist, Sandra Davidson, Aves Middleton, Helen Herrman, Kelsey Hegarty, Jane Gunn
Purpose – People with a history of depression are more likely to smoke and less likely to achieve abstinence from smoking long ter..
The effect of strategies of personal resilience on depression recovery in an Australian cohort: A mixed methods study
Frances E Griffiths, Felicity K Boardman, Patty Chondros, Christopher F Dowrick, Konstancja Densley, Kelsey L Hegarty, Jane Gunn
Strategies of personal resilience enable successful adaptation in adversity. Among patients experiencing depression symptoms, we e..
G-protein beta 3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees
Chad A Bousman, Maria Potiriadis, Ian P Everall, Jane M Gunn
BACKGROUND: Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been f..
St John's wort use in Australian general practice patients with depressive symptoms: their characteristics and use of other health services
Marie Pirotta, Konstancja Densley, Kirsty Forsdike, Meg Carter, Jane Gunn
BACKGROUND: While depression is frequently managed by general practitioners, often patients self-manage these symptoms with altern..
Effects of Neuregulin-1 Genetic Variation and Depression Symptom Severity on Longitudinal Patterns of Psychotic Symptoms in Primary Care Attendees
CA Bousman, M Potiriadis, IP Everall, JM Gunn
A better understanding of the factors associated with psychotic symptoms could aid early identification and treatment of psychotic..
Methylenetetrahydrofolate Reductase (MTHFR) Genetic Variation and Major Depressive Disorder Prognosis: A Five-Year Prospective Cohort Study of Primary Care Attendees
Chad A Bousman, Maria Potiriadis, Ian P Everall, Jane M Gunn
Methylenetetrahydrofolate reductase (MTHFR) genetic variation has been associated with the diagnosis of major depressive disorder ..
A trajectory-based approach to understand the factors associated with persistent depressive symptoms in primary care
Jane Gunn, Peter Elliott, Konstancja Densley, Aves Middleton, Gilles Ambresin, Christopher Dowrick, Helen Herrman, Kelsey Hegarty, Gail Gilchrist, Frances Griffiths
BACKGROUND: Depression screening in primary care yields high numbers. Knowledge of how depressive symptoms change over time is lim..