The diamond cohort study - long term outcomes of depressive

Self-reported reasons for reducing or stopping antidepressant medications in primary care: thematic analysis of the diamond longitudinal study

Amy Coe, Jane Gunn, Susan Fletcher, Elizabeth Murray, Catherine Kaylor-Hughes

2023-02-27

BACKGROUND: Current treatment guidelines advise that the deprescribing of antidepressants should occur around 6 months post-remiss..

Trajectories of intimate partner violence (IPV) in a primary care cohort of women with depressive symptoms

K Hegarty, K Densley, G Gilchrist, P Elliott, J Gunn

2023-02-01

Aims: To assess trajectories of women’s experience of intimate partner violence (IPV) over time, and baseline risk factors and ass..

Economic evaluation of the Target-D platform to match depression management to severity prognosis in primary care: A within-trial cost-utility analysis

Yong Yi Lee, Cathrine Mihalopoulos, Mary Lou Chatterton, Susan Fletcher, Patty Chondros, Konstancja L Densley, Elizabeth K Murray, Christopher Dowrick, Amy J Coe, Kelsey M Hegarty, Sandra Davidson, Caroline Wachtler, Victoria Palmer, Jane Gunn

2022-01-01

BACKGROUND: Target-D, a new person-centred e-health platform matching depression care to symptom severity prognosis (minimal/mild,..

Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial

Susan Fletcher, Patty Chondros, Konstancja Densley, Elizabeth Murray, Christopher Dowrick, Amy Coe, Kelsey Hegarty, Sandra Davidson, Caroline Wachtler, Cathrine Mihalopoulos, Yong Yi Lee, Mary Lou Chatterton, Victoria J Palmer, Jane Gunn

2021-02-01

BACKGROUND: Mental health treatment rates are increasing, but the burden of disease has not reduced. Tools to support efficient re..

Use of antidepressants with pharmacogenetic prescribing guidelines in a 10-year depression cohort of adult primary care patients

Chaten D Jessel, Sam Mostafa, Maria Potiriadis, Ian P Everall, Jane M Gunn, Chad A Bousman

2020-09-01

OBJECTIVE: To describe the usage patterns of antidepressants with published CYP2D6- and CYP2C19-based prescribing guidelines among..

Antidepressant treatment for primary care patients with depressive symptoms: Data from the diamond longitudinal cohort study

Sandra K Davidson, Helena Romaniuk, Patty Chondros, Christopher Dowrick, Jane Pirkis, Helen Herrman, Susan Fletcher, Jane Gunn

2020-01-20

BACKGROUND: In light of emerging evidence questioning the safety of antidepressants, it is timely to investigate the appropriatene..

Link-me: Protocol for a randomised controlled trial of a systematic approach to stepped mental health care in primary care

Susan Fletcher, Patty Chondros, Victoria J Palmer, Mary Lou Chatterton, Matthew J Spittal, Cathrine Mihalopoulos, Anna Wood, Meredith Harris, Philip Burgess, Bridget Bassilios, Jane Pirkis, Jane Gunn

2019-03-01

Primary care in Australia is undergoing significant reform, with a particular focus on cost-effective tailoring of mental health c..

Exploring comorbid depression and physical health trajectories: A case-based computational modelling approach

Brian Castellani, Frances Griffiths, Rajeev Rajaram, Jane Gunn

2018-12-01

While comorbid depression/physical health is a major clinical concern, the conventional methods of medicine make it difficult to m..

Development of a Mobile Clinical Prediction Tool to Estimate Future Depression Severity and Guide Treatment in Primary Care: User-Centered Design

Caroline Wachtler, Amy Coe, Sandra Davidson, Susan Fletcher, Antonette Mendoza, Leon Sterling, Jane Gunn

2018-04-01

BACKGROUND: Around the world, depression is both under- and overtreated. The diamond clinical prediction tool was developed to ass..

Development of a prognostic model for predicting depression severity in adult primary patients with depressive symptoms using the diamond longitudinal study

Patty Chondros, Sandra Davidson, Rory Wolfe, Gail Gilchrist, Christopher Dowrick, Frances Griffiths, Kelsey Hegarty, Helen Herrman, Jane Gunn

2018-02-01

BACKGROUND: Depression trajectories among primary care patients are highly variable, making it difficult to identify patients that..

Uptake of mental health websites in primary care: Insights from an Australian longitudinal cohort study of depression

Jane Gunn, Jacqui Cameron, Konstancja Densley, Sandra Davidson, Susie Fletcher, Victoria Palmer, Patty Chondros, Christopher Dowrick, Jane Pirkis

2018-01-01

OBJECTIVE: To describe the characteristics of primary care attendees with depressive symptoms who use mental health websites. METH..

Target-D: a stratified individually randomized controlled trial of the diamond clinical prediction tool to triage and target treatment for depressive symptoms in general practice: study protocol for a randomized controlled trial

Jane Gunn, Caroline Wachtler, Susan Fletcher, Sandra Davidson, Cathrine Mihalopoulos, Victoria Palmer, Kelsey Hegarty, Amy Coe, Elizabeth Murray, Christopher Dowrick, Gavin Andrews, Patty Chondros

2017-07-20

BACKGROUND: Depression is a highly prevalent and costly disorder. Effective treatments are available but are not always delivered ..

Polygenic phenotypic plasticity moderates the effects of severe childhood abuse on depressive symptom severity in adulthood: A 5-year prospective cohort study

Chad A Bousman, Jane M Gunn, Maria Potiriadis, Ian P Everall

2017-02-01

Objective To test the phenotypic plasticity framework using a polygenic approach in a prospective depression cohort of primary car..

Tailored integrated interventions for intimate partner violence and substance use are urgently needed

Gail Gilchrist, Kelsey Hegarty

2017-01-01

The Health Service Use of Frequent Users of Telephone Helplines in a Cohort of General Practice Attendees with Depressive Symptoms

Aves Middleton, Jane Pirkis, Patty Chondros, Bridget Bassilios, Jane Gunn

2016-09-01

We examined the relationship between frequent use of telephone helplines and health service use over time in a cohort of 789 gener..

The Brain-Derived neurotrophic Factor Val66Met Polymorphism Moderates the effects of childhood abuse on severity of Depressive symptoms in a Time-Dependent Manner

Caitlin Webb, Jane M Gunn, Maria Potiriadis, Ian P Everall, Chad A Bousman

2016-08-29

Cross-sectional studies have demonstrated that the brain-derived neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphis..

Impact of functional and structural social relationships on two year depression outcomes: A multivariate analysis

Sandra K Davidson, Christopher F Dowrick, Jane M Gunn

2016-03-15

BACKGROUND: High rates of persistent depression highlight the need to identify the risk factors associated with poor depression ou..

Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood

Timothy B Nguyen, Jane M Gunn, Maria Potiriadis, Ian P Everall, Chad A Bousman

2015-06-01

BACKGROUND: Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymor..

Mental health interventions and future major depression among primary care patients with subthreshold depression

Sandra K Davidson, Meredith G Harris, Christopher F Dowrick, Caroline A Wachtler, Jane Pirkis, Jane M Gunn

2015-05-15

BACKGROUND: Subthreshold depression is prevalent in primary care and is associated with poorer quality of life, higher health care..

What factors influence long-term antidepressant use in primary care? Findings from the Australian diamond cohort study

Gilles Ambresin, Victoria Palmer, Konstancja Densley, Christopher Dowrick, Gail Gilchrist, Jane M Gunn

2015-05-01

BACKGROUND: Antidepressants are one of the most commonly prescribed drugs in primary care. The rise in use is mostly due to an inc..

Factors associated with smoking and smoking cessation among primary care patients with depression: a naturalistic cohort study

Gail Gilchrist, Sandra Davidson, Aves Middleton, Helen Herrman, Kelsey Hegarty, Jane Gunn

2015-01-01

Purpose – People with a history of depression are more likely to smoke and less likely to achieve abstinence from smoking long ter..

The effect of strategies of personal resilience on depression recovery in an Australian cohort: A mixed methods study

Frances E Griffiths, Felicity K Boardman, Patty Chondros, Christopher F Dowrick, Konstancja Densley, Kelsey L Hegarty, Jane Gunn

2015-01-01

Strategies of personal resilience enable successful adaptation in adversity. Among patients experiencing depression symptoms, we e..

G-protein beta 3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees

Chad A Bousman, Maria Potiriadis, Ian P Everall, Jane M Gunn

2014-08-20

BACKGROUND: Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been f..

St John's wort use in Australian general practice patients with depressive symptoms: their characteristics and use of other health services

Marie Pirotta, Konstancja Densley, Kirsty Forsdike, Meg Carter, Jane Gunn

2014-06-26

BACKGROUND: While depression is frequently managed by general practitioners, often patients self-manage these symptoms with altern..

Effects of Neuregulin-1 Genetic Variation and Depression Symptom Severity on Longitudinal Patterns of Psychotic Symptoms in Primary Care Attendees

CA Bousman, M Potiriadis, IP Everall, JM Gunn

2014-01-01

A better understanding of the factors associated with psychotic symptoms could aid early identification and treatment of psychotic..

Methylenetetrahydrofolate Reductase (MTHFR) Genetic Variation and Major Depressive Disorder Prognosis: A Five-Year Prospective Cohort Study of Primary Care Attendees

Chad A Bousman, Maria Potiriadis, Ian P Everall, Jane M Gunn

2014-01-01

Methylenetetrahydrofolate reductase (MTHFR) genetic variation has been associated with the diagnosis of major depressive disorder ..

Who uses Australian chiropractic services?

Simon French, Konstancja Densley, Melanie Charity, Jane Gunn

2013-09-26

BACKGROUND: The use of chiropractic services is widespread, however, little is known about the characteristics of people who seek ..

A trajectory-based approach to understand the factors associated with persistent depressive symptoms in primary care

Jane Gunn, Peter Elliott, Konstancja Densley, Aves Middleton, Gilles Ambresin, Christopher Dowrick, Helen Herrman, Kelsey Hegarty, Gail Gilchrist, Frances Griffiths

2013-06-01

BACKGROUND: Depression screening in primary care yields high numbers. Knowledge of how depressive symptoms change over time is lim..

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic

2013-04-12

BACKGROUND: High-grade serous ovarian cancers are a distinct histological subtype of ovarian cancer often characterised by a dysfu..

An exploratory statistical approach to depression pattern identification

Qing Yi Feng, Frances Griffiths, Nick Parsons, Jane Gunn

2013-02-15

Depression is a complex phenomenon thought to be due to the interaction of biological, psychological and social factors. Currently..