Molecular control of virus-specific T cell responses
Grant number: 1003131 | Funding period: 2011 - 2013
Upon virus infection, a subset of white blood cells, called killer T cells, are recruited to fight the infection. This proposal aims to examine molecular changes that occur within killer T cells and impart their specific function. We also aim to understand how killer T cells are _programmed� as they establish immunological memory. This proposal will provide insights important for the design and improvement of vaccine strategies to fight pathogens such as influenza, HIV and even tumors.
Related publications (12)
KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8( ) T cell differentiation
Jasmine Li, Kristine Hardy, Moshe Olshansky, Adele Barugahare, Linden J Gearing, Julia E Prier, Xavier YX Sng, Michelle Ly Thai Nguyen, Dana Piovesan, Brendan E Russ, Nicole L La Gruta, Paul J Hertzog, Sudha Rao, Stephen J Turner
Naive CD8+ T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanis..
Early T-BET Expression Ensures an Appropriate CD8( ) Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection
Julia E Prier, Jasmine Li, Linden J Gearing, Moshe Olshansky, Xavier YX Sng, Paul J Hertzog, Stephen J Turner
Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of e..
CD4( ) T help promotes influenza virus-specific CD8( ) T cell memory by limiting metabolic dysfunction
Jolie G Cullen, Hayley A McQuilten, Kylie M Quinn, Moshe Olshansky, Brendan E Russ, Alison Morey, Sanna Wei, Julia E Prier, Nicole L La Gruta, Peter C Doherty, Stephen J Turner
There is continued interest in developing novel vaccine strategies that induce establish optimal CD8+ cytotoxic T lymphocyte (CTL)..
Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity
Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton
Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular ..
Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function
Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner
Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the ge..
Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation
Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton
Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GM-CSF) can fu..
Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8( ) T cells
Michelle LT Nguyen, Lauren Hatton, Jasmine Li, Moshe Olshansky, Anne Kelso, Brendan E Russ, Stephen J Turner
Numerous studies have focused on the molecular regulation of perforin (PFP) and granzyme B (GZMB) expression by activated cytotoxi..
Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8( ) T Cell Differentiation
Brendan E Russ, Moshe Olshanksy, Heather S Smallwood, Jasmine Li, Alice E Denton, Julia E Prier, Angus T Stock, Hayley A Croom, Jolie G Cullen, Michelle LT Nguyen, Stephanie Rowe, Matthew R Olson, David B Finkelstein, Anne Kelso, Paul G Thomas, Terry P Speed, Sudha Rao, Stephen J Turner
The molecular mechanisms that regulate the rapid transcriptional changes that occur during cytotoxic T lymphocyte (CTL) proliferat..
Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8( ) T cells
Alice E Denton, Brendan E Russ, Peter C Doherty, Sudha Rao, Stephen J Turner
Although the simultaneous engagement of multiple effector mechanisms is thought to characterize optimal CD8(+) T-cell immunity and..