Investigating the interface between host innate immune cells and a fungal pathogen
Grant number: 1006839 | Funding period: 2011 - 2014
Fungi which infect humans are a major health problem, especially for those with compromised immune systems (eg. AIDS, transplant and cancer patients). These fungi cause disease by evading the immune system whilst deriving nutrients for growth. Some fungi evade the immune system by residing within host cells; a hostile and nutrient poor environment. This project will study a pathway that we have shown is required for growth inside host cells. This knowledge will open new avenues for treatment.
Related publications (3)
Talaromyces marneffei simA Encodes a Fungal Cytochrome P450 Essential for Survival in Macrophages
Kylie J Boyce, David P De Souza, Saravanan Dayalan, Shivani Pasricha, Dedreia Tull, Malcolm J McConville, Alex Andrianopoulos
Fungi are adept at occupying specific environmental niches and often exploit numerous secondary metabolites generated by the cytoc..
Two-Component Signaling Regulates Osmotic Stress Adaptation via SskA and the High-Osmolarity Glycerol MAPK Pathway in the Human Pathogen Talaromyces marneffei
Kylie J Boyce, Cunwei Cao, Alex Andrianopoulos
For successful infection to occur, a pathogen must be able to evade or tolerate the host's defense systems. This requires the path..
Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei
Kylie J Boyce, Alisha McLauchlan, Lena Schreider, Alex Andrianopoulos
During infection, pathogens must utilise the available nutrient sources in order to grow while simultaneously evading or toleratin..