Renin angiotensin system in liver disease
Grant number: 1008252 | Funding period: 2011 - 2013
Cirrhosis of the liver due to chronic hepatitis and other common liver diseases is now a major cause of illness and death in Australia. This project will examine how a hormone system called the renin angiotensin system contributes to the development of liver damage in these diseases. We will study whether drugs targeting this system can be used to reduce liver scarring and prevent the development of cirrhosis and its complications.
Related publications (3)
Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
Sabine Klein, Chandana B Herath, Robert Schierwagen, Josephine Grace, Tom Haltenhof, Frank E Uschner, Christian P Strassburg, Tilman Sauerbruch, Thomas Walther, Peter W Angus, Jonel Trebicka
BACKGROUND & AIMS: Although in cirrhosis with portal hypertension levels of the vasoconstrictor angiotensin II are increased, this..
ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice
Kai Y Mak, Ruth Chin, Sharon C Cunningham, Miriam R Habib, Joseph Torresi, Alexandra F Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath
Angiotensin converting enzyme 2 (ACE2) which breaks down profibrotic peptide angiotensin II to antifibrotic peptide angiotensin-(1..