Which malaria proteins are targets of protective immunity?

Grant number: 1007954 | Funding period: 2011 - 2014

Completed

Abstract

The malaria parasite changes molecules it uses to cause disease, this alters its appearance so it can escape people's immune response. However some of these molecules are similar in the parasites that cause the most severe disease. We aim to identify these similar molecules because they may make useful vaccines for protecting people from severe malaria disease.

Related publications (4)

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Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1

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Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a diverse family of multidomain proteins expressed on the surface o..

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The &ITPlasmodium falciparum &ITtranscriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding &ITvar &ITgenes

Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy

2018-03-01

Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment..

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Activation and clustering of a Plasmodium falciparum var gene are affected by subtelomeric sequences

Michael F Duffy, Jingyi Tang, Fransisca Sumardy, Hanh HT Nguyen, Shamista A Selvarajah, Gabrielle A Josling, Karen P Day, Michaela Petter, Graham V Brown

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The Plasmodium falciparum var multigene family encodes the cytoadhesive, variant antigen PfEMP1. P. falciparum antigenic variation..

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Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Michael F Duffy, Rintis Noviyanti, Takafumi Tsuboi, Zhi-Ping Feng, Leily Trianty, Boni F Sebayang, Eizo Takashima, Fransisca Sumardy, Daniel A Lampah, Louise Turner, Thomas Lavstsen, Freya JI Fowkes, Peter Siba, Stephen J Rogerson, Thor G Theander, Jutta Marfurt, Ric N Price, Nicholas M Anstey, Graham V Brown, Anthony T Papenfuss

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BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic..