SEZ6 and neuronal calcium signalling in synapse development

Grant number: 1008046 | Funding period: 2011 - 2014

Completed

Abstract

Inappropriate development and function of neuronal circuits is a universal feature of neurological disorders of cognition such as Down syndrome, autism spectrum disorders and Fragile X mental retardation, epilepsy, schizophrenia and Alzheimer�s disease. In these diseases, neurons exhibit abnormal neuronal branches (dendrites) and abnormal connections on dendritic spines. This research is aimed at understanding the mechanisms controlling dendrite development that underpin proper neuronal wiring.

University of Melbourne Researchers