Cohesin role in colon cancer

Grant number: 1007659 | Funding period: 2011 - 2013

Completed

Abstract

Rad21 is a gene, present in many species and essential for accurate chromosome separation and DNA damage repair. Based on its known function in different species, we predict that its� dysfunction fuels cancer progression by promoting genetic instability, which is commonly associated with human cancers. This study will use unique mouse mutant models to investigate the function of this potential cancer-causing gene in colon cancer.

Related publications (8)

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Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis

Dane Cheasley, Lloyd Pereira, Shienny Sampurno, Oliver Sieber, Robert Jorissen, Huiling Xu, Markus Germann, Yuqian Yan, Robert G Ramsay, Jordane Malaterre

2015-08-01

UNLABELLED: Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (Myb(P..

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Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C Eder, Robyn L Ward, Nicholas J Hawkins, Richard W Tothill, Long Chen, Neil J Mortensen, Stephen B Fox, Michael J McKay, Robert G Ramsay

2014-12-11

Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intesti..

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Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

Markus Germann, Huiling Xu, Jordane Malaterre, Shienny Sampurno, Mathilde Huyghe, Dane Cheasley, Silvia Fre, Robert G Ramsay

2014-11-01

Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their co..

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RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas

S Deb, H Xu, J Tuynman, J George, Y Yan, J Li, RL Ward, N Mortensen, NJ Hawkins, MJ McKay, RG Ramsay, SB Fox

2014-03-18

BACKGROUND: RAD21 is a component of the cohesion complex and is integral to chromosome segregation and error-free DNA repair. RAD2..

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The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

S Sampurno, A Bijenhof, D Cheasley, H Xu, S Robine, D Hilton, WS Alexander, L Pereira, T Mantamadiotis, J Malaterre, RG Ramsay

2013-04-01

The gastrointestinal (GI) epithelium is constantly renewing, depending upon the intestinal stem cells (ISC) regulated by a spectru..

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Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

Andre J Faure, Dominic Schmidt, Stephen Watt, Petra C Schwalie, Michael D Wilson, Huiling Xu, Robert G Ramsay, Duncan T Odom, Paul Flicek

2012-11-01

The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master reg..

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RAD21 Mutations Cause a Human Cohesinopathy

Matthew A Deardorff, Jonathan J Wilde, Melanie Albrecht, Emma Dickinson, Stephanie Tennstedt, Diana Braunholz, Maren Moennich, Yuqian Yan, Weizhen Xu, Maria Concepcion Gil-Rodriguez, Dinah Clark, Hakon Hakonarson, Sara Halbach, Laura Daniela Michelis, Abhinav Rampuria, Eva Rossier, Stephanie Spranger, Lionel Van Maldergem, Sally Ann Lynch, Gabriele Gillessen-Kaesbach

2012-06-08

The evolutionarily conserved cohesin complex was originally described for its role in regulating sister-chromatid cohesion during ..

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Can corruption of chromosome cohesion create a conduit to cancer?

Huiling Xu, Jonathan M Tomaszewski, Michael J McKay

2011-03-01

Cohesin is a conserved multisubunit protein complex with diverse cellular roles, making key contributions to the coordination of c..

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