Cohesin Role in Colon Cancer

Grant number: 1007659 | Funding period: 2011 - 2013

Completed

Abstract

Rad21 is a gene, present in many species and essential for accurate chromosome separation and DNA damage repair. Based on its known function in different species, we predict that itsï¿1⁄2 dysfunction fuels cancer progression by promoting genetic instability, which is commonly associated with human cancers. This study will use unique mouse mutant models to investigate the function of this potential cancer-causing gene in colon cancer.

Related publications (8)

Scholarly works icon

Defective Myb function ablates Cyclin E1 expression and perturbs intestinal carcinogenesis

D Cheasley, L Pereira, S Sampurno, O Sieber, R Jorissen, H Xu, M Germann, Y Yuqian, RG Ramsay, J Malaterre

2015-08-01

Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (MybPlt4) were exa..

Scholarly works icon

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

H Xu, Y Yan, S Deb, D Rangasamy, M Germann, J Malaterre, NC Eder, RL Ward, NJ Hawkins, RW Tothill, L Chen, NJ Mortensen, SB Fox, MJ McKay, RG Ramsay

2014-12-11

Loss of heterozygosity (LOH) of the adenomatous polyposis coli (. APC) gene triggers a series of molecular events leading to intes..

Scholarly works icon

Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

M Germann, H Xu, J Malaterre, S Sampurno, M Huyghe, D Cheasley, S Fre, RG Ramsay

2014-11-01

Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their co..

Scholarly works icon

RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas

S Deb, H Xu, J Tuynman, J George, Y Yan, J Li, RL Ward, N Mortensen, NJ Hawkins, MJ McKay, RG Ramsay, SB Fox

2014-03-18

Background: RAD21 is a component of the cohesion complex and is integral to chromosome segregation and error-free DNA repair. RAD2..

Scholarly works icon

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

S Sampurno, A Bijenhof, D Cheasley, H Xu, S Robine, D Hilton, WS Alexander, L Pereira, T Mantamadiotis, J Malaterre, RG Ramsay

2013-04-01

The gastrointestinal (GI) epithelium is constantly renewing, depending upon the intestinal stem cells (ISC) regulated by a spectru..

Scholarly works icon

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

AJ Faure, D Schmidt, S Watt, PC Schwalie, MD Wilson, H Xu, RG Ramsay, DT Odom, P Flicek

2012-11-01

The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master reg..

Scholarly works icon

RAD21 mutations cause a human cohesinopathy

MA Deardorff, JJ Wilde, M Albrecht, E Dickinson, S Tennstedt, D Braunholz, M Mönnich, Y Yan, W Xu, MC Gil-Rodríguez, D Clark, H Hakonarson, S Halbach, LD Michelis, A Rampuria, E Rossier, S Spranger, L Van Maldergem, SA Lynch, G Gillessen-Kaesbach

2012-06-08

The evolutionarily conserved cohesin complex was originally described for its role in regulating sister-chromatid cohesion during ..

Scholarly works icon

Can corruption of chromosome cohesion create a conduit to cancer?

H Xu, JM Tomaszewski, MJ McKay

2011-01-01

Cohesin is a conserved multisubunit protein complex with diverse cellular roles, making key contributions to the coordination of c..

University of Melbourne Researchers