Effect of androgens on muscle, bone and fat in men
Grant number: 1006407 | Funding period: 2011 - 2014
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.
Related publications (15)
Biomechanical Leg Muscle Function During Stair Ambulation in Men Receiving Androgen Deprivation Therapy
Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..
Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy
Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann
CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..
Persisting adverse body composition changes 2 years after cessation of androgen deprivation therapy for localised prostate cancer
Ada S Cheung, Alistair J Tinson, Stefan Milevski, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: Hypogonadism from androgen deprivation therapy (ADT) for prostate cancer causes adverse body composition changes associ..
Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer
Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann
Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..
Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men
Rudolf Hoermann, Ada S Cheung, Michele Milne, Mathis Grossmann
OBJECTIVE: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes i..
Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospecti..
Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study
Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demons..
Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer
Ada S Cheung, Rudolf Hoermann, Philippe Dupuis, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with insulin resistance and frailty, controlled prospectiv..
Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men
AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann
Quantification of abdominal visceral adipose tissue (VAT) is important to understand obesity-related comorbidities. We hypothesize..
Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study
Mathis Grossmann, Rudolf Hoermann, Claire Francis, Emma J Hamilton, Aye Tint, Tu'uhevaha Kaitu'u-Lino, Kent Kuswanto, Martha Lappas, Ken Sikaris, Jeffery D Zajac, Michael Permezel, Stephen Tong
BACKGROUND: There has been recent evidence suggesting the presence of anti-thyroid peroxidase antibodies (TPOAb) increases the ris..
A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma
Felipe R Lorenzo, Chunzhang Yang, Mark Ng Tang Fui, Hariprasad Vankayalapati, Zhengping Zhuang, Huynh Thanh, Mathis Grossmann, Karel Pacak, Josef T Prchal
Congenital polycythemias have diverse etiologies, including mutations in the hypoxia sensing pathway. These include HIF2A at exon ..
Low testosterone levels as an independent predictor of mortality in men with chronic liver disease
Mathis Grossmann, Rudolf Hoermann, Linsey Gani, Irene Chan, Ada Cheung, Paul J Gow, Angela Li, Jeffrey D Zajac, Peter Angus
OBJECTIVE: To examine the prevalence and prognostic implications of low serum testosterone levels in men with chronic liver diseas..