Effect of androgens on muscle, bone and fat in men

Grant number: 1006407 | Funding period: 2011 - 2014

Completed

Abstract

Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases general well being and contributes to muscle weakness, bone fragility and weight gain. By using cutting edge imaging and molecular technologies, we will help to explain the underlying mechanisms of how AD leads to these negative effects. This should ultimately lead to reduction of adverse outcomes of AD, which include fractures and cardiovascular events.

Related publications (11)

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Biomechanical leg muscle function during stair ambulation in men receiving androgen deprivation therapy.

Ada S Cheung, Hans A Gray, Anthony G Schache, Rudolf Hoermann, Jarrod Bicknell, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

2019-07-16

BACKGROUND: The role of testosterone in maintaining functional performance in older men remains uncertain. METHODS: We conducted a..

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Selective Loss of Levator Ani and Leg Muscle Volumes in Men Undergoing Androgen Deprivation Therapy

Ada S Cheung, Christopher Cunningham, Dong-Kyoon Daniel Ko, Vivian Ly, Hans Gray, Rudolf Hoermann, Boyd JG Strauss, Ebrahim Bani Hassan, Gustavo Duque, Peter Ebeling, Marcus G Pandy, Jeffrey D Zajac, Mathis Grossmann

2019-06-01

CONTEXT: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a selective loss of leg muscle function during walk..

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Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer

Ada S Cheung, Casey de Rooy, Itamar Levinger, Kesha Rana, Michele V Clarke, Jackie M How, Andrew Garnham, Catriona McLean, Jeffrey D Zajac, Rachel A Davey, Mathis Grossmann

2017-11-01

Androgen deprivation therapy (ADT) decreases muscle mass and function but no human studies have investigated the underlying geneti..

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Effects of androgen deprivation therapy on telomere length

Ada S Cheung, Bu B Yeap, Rudolf Hoermann, Jennie Hui, John P Beilby, Mathis Grossmann

2017-10-01

OBJECTIVE: Recent evidence suggests that androgens either directly or via aromatisation to oestradiol may regulate telomere length..

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Hypothalamic-Pituitary-Thyroid Axis Set Point Alterations Are Associated With Body Composition in Androgen-Deprived Men

Rudolf Hoermann, Ada S Cheung, Michele Milne, Mathis Grossmann

2017-07-01

Objective: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes i..

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Quality of life decrements in men with prostate cancer undergoing androgen deprivation therapy

Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann

2017-03-01

OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospecti..

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Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case-control study

Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann

2017-02-01

BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demons..

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Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men

AS Cheung, C de Rooy, R Hoermann, EJ Gianatti, EJ Hamilton, G Roff, JD Zajac, M Grossmann

2016-08-01

Quantification of abdominal visceral adipose tissue (VAT) is important to understand obesity-related comorbidities. We hypothesize..

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Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study

Mathis Grossmann, Rudolf Hoermann, Claire Francis, Emma J Hamilton, Aye Tint, Tu'uhevaha Kaitu'u-Lino, Kent Kuswanto, Martha Lappas, Ken Sikaris, Jeffery D Zajac, Michael Permezel, Stephen Tong

2013-05-14

BACKGROUND: There has been recent evidence suggesting the presence of anti-thyroid peroxidase antibodies (TPOAb) increases the ris..

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Androgens, diabetes and prostate cancer

Mathis Grossmann, Gary Wittert

2012-10-01

Metabolic disorders such as diabetes, obesity and the metabolic syndrome have been shown to modulate prostate cancer (PCa) risk an..

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Low testosterone levels as an independent predictor of mortality in men with chronic liver disease

Mathis Grossmann, Rudolf Hoermann, Linsey Gani, Irene Chan, Ada Cheung, Paul J Gow, Angela Li, Jeffrey D Zajac, Peter Angus

2012-08-01

OBJECTIVE: To examine the prevalence and prognostic implications of low serum testosterone levels in men with chronic liver diseas..

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